乙酰胆碱酯酶[1]（英语：Acetylcholinesterase，简称为AChE，EC 3.1.1.7）是一种降解（通过其水解活性）神经递质乙酰胆碱成为胆碱和乙酸的酶。该酶主要存在于神经肌肉接头与胆碱能神经系统中，在这些地方该酶的活性就是为了终止突触传递。乙酰胆碱酯酶具有极高的水解活性——每秒钟一分子的乙酰胆碱酯酶可以水解25000分子的乙酰胆碱。经乙酰胆碱酯酶作用而产生的胆碱被重新利用——通过重摄取被转运进入神经末梢，在那里被重新利用以合成新的乙酰胆碱分子[2]。
[编辑] 参考文献
- ^ [1]
- ^ Dale Purves, George J. Augustine, David Fitzpatrick, William C. Hall, Anthony-Samuel LaMantia, James O. McNamara, and Leonard E. White. Neuroscience. 4th ed.. Sinauer Associates. 2008: 121–2. ISBN 978-0-87893-697-7.
[编辑] 深入阅读
- Silman I, Futerman AH. Modes of attachment of acetylcholinesterase to the surface membrane.. Eur. J. Biochem.. 1988, 170 (1-2): 11–22. doi:10.1111/j.1432-1033.1987.tb13662.x. PMID 3319614.
- Soreq H, Seidman S. Acetylcholinesterase--new roles for an old actor.. Nat. Rev. Neurosci.. 2001, 2 (4): 294–302. doi:10.1038/35067589. PMID 11283752.
- Shen T, Tai K, Henchman RH, McCammon JA. Molecular dynamics of acetylcholinesterase.. Acc. Chem. Res.. 2003, 35 (6): 332–40. doi:10.1021/ar010025i. PMID 12069617.
- Pakaski M, Kasa P. Role of acetylcholinesterase inhibitors in the metabolism of amyloid precursor protein.. Current drug targets. CNS and neurological disorders. 2003, 2 (3): 163–71. doi:10.2174/1568007033482869. PMID 12769797.
- Meshorer E, Soreq H. Virtues and woes of AChE alternative splicing in stress-related neuropathologies.. Trends Neurosci.. 2006, 29 (4): 216–24. doi:10.1016/j.tins.2006.02.005. PMID 16516310.
- Ehrlich G, Viegas-Pequignot E, Ginzberg D, et al.. Mapping the human acetylcholinesterase gene to chromosome 7q22 by fluorescent in situ hybridization coupled with selective PCR amplification from a somatic hybrid cell panel and chromosome-sorted DNA libraries.. Genomics. 1992, 13 (4): 1192–7. doi:10.1016/0888-7543(92)90037-S. PMID 1380483.
- Spring FA, Gardner B, Anstee DJ. Evidence that the antigens of the Yt blood group system are located on human erythrocyte acetylcholinesterase.. Blood. 1992, 80 (8): 2136–41. PMID 1391965.
- Shafferman A, Kronman C, Flashner Y, et al.. Mutagenesis of human acetylcholinesterase. Identification of residues involved in catalytic activity and in polypeptide folding.. J. Biol. Chem.. 1992, 267 (25): 17640–8. PMID 1517212.
- Getman DK, Eubanks JH, Camp S, et al.. The human gene encoding acetylcholinesterase is located on the long arm of chromosome 7.. Am. J. Hum. Genet.. 1992, 51 (1): 170–7. PMID 1609795.
- Li Y, Camp S, Rachinsky TL, et al.. Gene structure of mammalian acetylcholinesterase. Alternative exons dictate tissue-specific expression.. J. Biol. Chem.. 1992, 266 (34): 23083–90. PMID 1744105.
- Velan B, Grosfeld H, Kronman C, et al.. The effect of elimination of intersubunit disulfide bonds on the activity, assembly, and secretion of recombinant human acetylcholinesterase. Expression of acetylcholinesterase Cys-580----Ala mutant.. J. Biol. Chem.. 1992, 266 (35): 23977–84. PMID 1748670.
- Soreq H, Ben-Aziz R, Prody CA, et al.. Molecular cloning and construction of the coding region for human acetylcholinesterase reveals a G + C-rich attenuating structure.. Proc. Natl. Acad. Sci. U.S.A.. 1991, 87 (24): 9688–92. doi:10.1073/pnas.87.24.9688. PMID 2263619.
- Chhajlani V, Derr D, Earles B, et al.. Purification and partial amino acid sequence analysis of human erythrocyte acetylcholinesterase.. FEBS Lett.. 1989, 247 (2): 279–82. doi:10.1016/0014-5793(89)81352-3. PMID 2714437.
- Lapidot-Lifson Y, Prody CA, Ginzberg D, et al.. Coamplification of human acetylcholinesterase and butyrylcholinesterase genes in blood cells: correlation with various leukemias and abnormal megakaryocytopoiesis.. Proc. Natl. Acad. Sci. U.S.A.. 1989, 86 (12): 4715–9. doi:10.1073/pnas.86.12.4715. PMID 2734315.
- Bazelyansky M, Robey E, Kirsch JF. Fractional diffusion-limited component of reactions catalyzed by acetylcholinesterase.. Biochemistry. 1986, 25 (1): 125–30. doi:10.1021/bi00349a019. PMID 3954986.
- Gaston SM, Marchase RB, Jakoi ER. Brain ligatin: a membrane lectin that binds acetylcholinesterase.. J. Cell. Biochem.. 1982, 18 (4): 447–59. doi:10.1002/jcb.1982.240180406. PMID 7085778.
- Ordentlich A, Barak D, Kronman C, et al.. Contribution of aromatic moieties of tyrosine 133 and of the anionic subsite tryptophan 86 to catalytic efficiency and allosteric modulation of acetylcholinesterase.. J. Biol. Chem.. 1995, 270 (5): 2082–91. doi:10.1074/jbc.270.5.2082. PMID 7836436.
- Maruyama K, Sugano S. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.. Gene. 1994, 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Ben Aziz-Aloya R, Sternfeld M, Soreq H. Promoter elements and alternative splicing in the human ACHE gene.. Prog. Brain Res.. 1994, 98: 147–53. PMID 8248502.
- Massoulie J, Pezzementi L, Bon S, Krejci E, Valette F. Molecular and Cellular Biology of Cholinesterases.. Prog. Brain Res.. 1993, 93 (1): 31–91. PMID 8321908.
[编辑] 外部链接
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蛋白质数据库画廊
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1b41: HUMAN ACETYLCHOLINESTERASE COMPLEXED WITH FASCICULIN-II, GLYCOSYLATED PROTEIN
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1f8u: CRYSTAL STRUCTURE OF MUTANT E202Q OF HUMAN ACETYLCHOLINESTERASE COMPLEXED WITH GREEN MAMBA VENOM PEPTIDE FASCICULIN-II
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1vzj: STRUCTURE OF THE TETRAMERIZATION DOMAIN OF ACETYLCHOLINESTERASE: FOUR-FOLD INTERACTION OF A WWW MOTIF WITH A LEFT-HANDED POLYPROLINE HELIX
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Template:胆碱能
