二氢硫辛酰胺脱氢酶

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二氢硫辛酰胺脱氢酶

PDB渲染的1zy8
有效结构
PDB 直系同源检索:PDBe, RCSB
标识
代号 DLD; DLDH; E3; GCSL; LAD; PHE3
扩展标识 遗传学238331 鼠基因107450 同源基因84 GeneCards: DLD Gene
EC編號 1.8.1.4
直系同源体
物种 人类 鼠类
Entrez 1738 13382
Ensembl ENSG00000091140 ENSMUSG00000020664
UniProt P09622 O08749
mRNA序列 NM_000108 NM_007861.4
蛋白序列 NP_000099 NP_031887.2
基因位置 Chr 7:
107.53 – 107.57 Mb
Chr 12:
32.02 – 32.04 Mb
PubMed查询 [2] [3]
二氢硫辛酰胺脱氢酶
识别码
EC编号 1.8.1.4
CAS号 9001-18-7
数据库
IntEnz IntEnz浏览
BRENDA BRENDA入口
ExPASy NiceZyme浏览
KEGG KEGG入口
MetaCyc 代谢路径
PRIAM 概述
PDB RCSB PDB PDBe PDBsum
基因本体 AmiGO / EGO

二氢硫辛酰胺脱氢酶[1]英语Dihydrolipoamide dehydrogenase,又称为硫辛酰胺脱氢酶EC 1.8.1.4)是以NAD+为辅基接受质子与电子的一种脱氢酶,是大小为51千道尔顿亚基的同二聚体,其中每个都与一分子的黄素腺嘌呤二核苷酸以共价键的形式相连。在哺乳动物线粒体三羧酸循环中,该酶与丙酮酸脱氢酶二氢硫辛酰基乙酰基转基酶一起组成中丙酮酸脱氢酶复合体,同时该酶亦是α-酮戊二酸脱氢酶复合体中的一个组分。二氢硫辛酰胺脱氢酶的主要任务是负责将复合物中另一组分硫辛酰胺转乙酰基酶(或二氢硫辛酰琥珀酰转移酶)的辅基二氢硫辛酰胺脱氢从而转化为氧化型硫辛酰胺,该酶也是线粒体甘氨酸剪切体系的组分。

参考文献[编辑]

  1. ^ [1]

深入阅读[编辑]

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