二氢硫辛酰胺脱氢酶

编辑

二氢硫辛酰胺脱氢酶
PDB渲染的1zy8
有效结构
1ZMC, 1ZMD, 1ZY8, 2F5Z
标识
代号	DLD; DLDH; E3; GCSL; LAD; PHE3
扩展标识	遗传学：238331 鼠基因：107450 同源基因：84
酶分类号	1.8.1.4
基因本体论描述 分子功能 · dihydrolipoyl dehydrogenase activity · electron carrier activity · oxidoreductase activity · lipoamide binding · flavin adenine dinucleotide binding · NAD binding 细胞成分 · cytoplasm · mitochondrion · mitochondrial matrix · flagellum · acrosomal matrix · oxoglutarate dehydrogenase complex · pyruvate dehydrogenase complex 生物过程 · pyruvate metabolic process · tricarboxylic acid cycle · 2-oxoglutarate metabolic process · mitochondrial electron transport, NADH to ubiquinone · proteolysis · lysine catabolic process · gastrulation · aging · branched chain family amino acid catabolic process · lipoate metabolic process · regulation of acetyl-CoA biosynthetic process from pyruvate · cellular nitrogen compound metabolic process · regulation of membrane potential · cell redox homeostasis · sperm capacitation · dihydrolipoamide metabolic process
直系同源体
物种	人类	鼠类
Entrez	1738	13382
Ensembl	ENSG00000091140	ENSMUSG00000020664
UniProt	P09622	O08749
参考序列	NM_000108 (mRNA)	NM_007861.4 (mRNA)
	NP_000099（蛋白）	NP_031887.2（蛋白）
基因位置	染色体7: 107.53 - 107.57 Mb	染色体12: 32.02 - 32.04 Mb
PubMed查询	[2]	[3]

二氢硫辛酰胺脱氢酶
命名 系统命名 缩写
识别码
EC编号	1.8.1.4
CAS号	9001-18-7
数据库
IntEnz	IntEnz浏览
BRENDA	BRENDA入口
ExPASy	NiceZyme浏览
KEGG	KEGG入口
MetaCyc	代谢路径
PRIAM	概述
PDB	RCSB PDB PDBe PDBsum
基因本体	AmiGO / EGO
搜索 PMC 相关文献 PubMed 相关文献

二氢硫辛酰胺脱氢酶（英语：Dihydrolipoamide dehydrogenase，又称为硫辛酰胺脱氢酶，EC 1.8.1.4）是以NAD⁺为辅基接受质子与电子的一种脱氢酶，是大小为51千道尔顿亚基的同二聚体，其中每个都与一分子的黄素腺嘌呤二核苷酸以共价键的形式相连。在哺乳动物的线粒体三羧酸循环中，该酶与丙酮酸脱氢酶和二氢硫辛酰基乙酰基转基酶一起组成中丙酮酸脱氢酶复合体，同时该酶亦是α-酮戊二酸脱氢酶复合体中的一个组分。二氢硫辛酰胺脱氢酶的主要任务是负责将复合物中另一组分硫辛酰胺转乙酰基酶（或二氢硫辛酰琥珀酰转移酶）的辅基二氢硫辛酰胺脱氢从而转化为氧化型硫辛酰胺，该酶也是线粒体甘氨酸剪切体系的组分。

深入阅读

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外部链接

• MeSH（醫學主題詞）上面的Dihydrolipoamide+dehydrogenase

二氢硫辛酰胺脱氢酶引用了美国国家医学图书馆提供的資料，这些資料属于公共领域。