促卵泡激素β亚基

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Follicle stimulating hormone, beta polypeptide
促卵泡激素,β多肽

PDB rendering based on 1fl7.
有效结构
PDB 直系同源检索:PDBe, RCSB
标识
代号 FSHB
扩展标识 遗传学136530 鼠基因95582 同源基因430 GeneCards: FSHB Gene
RNA表达模式
PBB GE FSHB 214489 at tn.png
更多表达数据
直系同源体
物种 人类 鼠类
Entrez 2488 14308
Ensembl ENSG00000131808 ENSMUSG00000027120
UniProt P01225 Q60687
mRNA序列 NM_000510 NM_008045
蛋白序列 NP_000501 NP_032071
基因位置 Chr 11:
30.25 – 30.26 Mb
Chr 2:
107.06 – 107.06 Mb
PubMed查询 [1] [2]

促卵泡激素β亚基英语Follitropin subunit betafollicle-stimulating hormone beta subunit 缩写FSH-B)是一种由人类基因FSHB 编码的蛋白质[1][2][3] 。其RNA的选择性剪接可形成该蛋白的两种蛋白异型体。

功能[编辑]

垂體醣蛋白激素家族包括促卵泡激素黄体生成素人绒毛膜促性腺激素促甲状腺激素,所有这些糖蛋白激素都包括一个共同的α亚基和一个特异的β亚基。FSHB 基因编码的就是促卵泡激素的β亚基。 In conjunction with luteinizing hormone, follicle-stimulating hormone induces egg and sperm production.[3]

参考文献[编辑]

  1. ^ Watkins PC, Eddy R, Beck AK, Vellucci V, Leverone B, Tanzi RE, Gusella JF, Shows TB. DNA sequence and regional assignment of the human follicle-stimulating hormone beta-subunit gene to the short arm of human chromosome 11. DNA. Aug 1987, 6 (3): 205–12. doi:10.1089/dna.1987.6.205. PMID 2885163. 
  2. ^ Shome B, Parlow AF, Liu WK, Nahm HS, Wen T, Ward DN. A reevaluation of the amino acid sequence of human follitropin beta-subunit. J Protein Chem. Sep 1989, 7 (4): 325–39. doi:10.1007/BF01024882. PMID 3151250. 
  3. ^ 3.0 3.1 Entrez Gene: FSHB follicle stimulating hormone, beta polypeptide. 

延伸阅读[编辑]

  • Barrios-De-Tomasi J, Timossi C, Merchant H et al. Assessment of the in vitro and in vivo biological activities of the human follicle-stimulating isohormones. Mol. Cell. Endocrinol. 2002, 186 (2): 189–98. doi:10.1016/S0303-7207(01)00657-8. PMID 11900895. 
  • Saxena BB, Rathnam P. Amino acid sequence of the beta subunit of follicle-stimulating hormone from human pituitary glands. J. Biol. Chem. 1976, 251 (4): 993–1005. PMID 1249074. 
  • Keene JL, Matzuk MM, Otani T et al. Expression of biologically active human follitropin in Chinese hamster ovary cells. J. Biol. Chem. 1989, 264 (9): 4769–75. PMID 2494176. 
  • Jameson JL, Becker CB, Lindell CM, Habener JF. Human follicle-stimulating hormone beta-subunit gene encodes multiple messenger ribonucleic acids. Mol. Endocrinol. 1988, 2 (9): 806–15. doi:10.1210/mend-2-9-806. PMID 3139991. 
  • Shome B, Parlow AF. Human follicle stimulating hormone: first proposal for the amino acid sequence of the hormone-specific, beta subunit (hFSHb). J. Clin. Endocrinol. Metab. 1974, 39 (1): 203–5. doi:10.1210/jcem-39-1-203. PMID 4835136. 
  • Fujiki Y, Rathnam P, Saxena BB. Studies on the disulfide bonds in human pituitary follicle-stimulating hormone. Biochim. Biophys. Acta. 1980, 624 (2): 428–35. PMID 6774759. 
  • Böckers TM, Nieschlag E, Kreutz MR, Bergmann M. Localization of follicle-stimulating hormone (FSH) immunoreactivity and hormone receptor mRNA in testicular tissue of infertile men. Cell Tissue Res. 1995, 278 (3): 595–600. doi:10.1007/BF00331379. PMID 7850869. 
  • Matthews CH, Borgato S, Beck-Peccoz P et al. Primary amenorrhoea and infertility due to a mutation in the beta-subunit of follicle-stimulating hormone. Nat. Genet. 1993, 5 (1): 83–6. doi:10.1038/ng0993-83. PMID 8220432. 
  • Layman LC, Lee EJ, Peak DB et al. Delayed puberty and hypogonadism caused by mutations in the follicle-stimulating hormone beta-subunit gene. N. Engl. J. Med. 1997, 337 (9): 607–11. doi:10.1056/NEJM199708283370905. PMID 9271483. 
  • Cargill M, Altshuler D, Ireland J et al. Characterization of single-nucleotide polymorphisms in coding regions of human genes. Nat. Genet. 1999, 22 (3): 231–8. doi:10.1038/10290. PMID 10391209. 
  • Grasso P, Rozhavskaya-Arena M, Reichert LE. Cysteine residues in a synthetic peptide corresponding to human follicle-stimulating hormone beta-subunit receptor-binding domain 81-95 [hFSH-beta-(81-95)] modulate the in vivo effects of hFSH-beta-(81-95) on the mouse estrous cycle. Regul. Pept. 1999, 81 (1–3): 67–71. doi:10.1016/S0167-0115(99)00022-1. PMID 10395410. 
  • Ben-Menahem D, Hyde R, Pixley M et al. Synthesis of multi-subunit domain gonadotropin complexes: a model for alpha/beta heterodimer formation. Biochemistry. 1999, 38 (46): 15070–7. doi:10.1021/bi991510c. PMID 10563789. 
  • Dias Neto E, Correa RG, Verjovski-Almeida S et al. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. Proc. Natl. Acad. Sci. U.S.A. 2000, 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800. 
  • Hartley JL, Temple GF, Brasch MA. DNA Cloning Using In Vitro Site-Specific Recombination. Genome Res. 2001, 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863. 
  • Fox KM, Dias JA, Van Roey P. Three-dimensional structure of human follicle-stimulating hormone. Mol. Endocrinol. 2001, 15 (3): 378–89. doi:10.1210/me.15.3.378. PMID 11222739. 
  • Amoresano A, Orrù S, Siciliano RA 等. Assignment of the complete disulphide bridge pattern in the human recombinant follitropin beta-chain. Biol. Chem. 2002, 382 (6): 961–8. doi:10.1515/BC.2001.120. PMID 11501762. 
  • Walton WJ, Nguyen VT, Butnev VY et al. Characterization of human FSH isoforms reveals a nonglycosylated beta-subunit in addition to the conventional glycosylated beta-subunit. J. Clin. Endocrinol. Metab. 2001, 86 (8): 3675–85. doi:10.1210/jc.86.8.3675. PMID 11502795.