促甲状腺激素受体

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Thyroid stimulating hormone receptor
促甲状腺激素受体

Rendering based on PDB 1XUM.
有效结构
PDB 直系同源检索:PDBe, RCSB
标识
代号 TSHR; CHNG1; LGR3; hTSHR-I
扩展标识 遗传学603372 鼠基因98849 同源基因315 IUPHAR:  TSH ChEMBL: 1963 GeneCards: TSHR Gene
RNA表达模式
PBB GE TSHR 210055 at tn.png
PBB GE TSHR 215442 s at tn.png
PBB GE TSHR 215443 at tn.png
更多表达数据
直系同源体
物种 人类 鼠类
Entrez 7253 22095
Ensembl ENSG00000165409 ENSMUSG00000020963
UniProt P16473 P47750
mRNA序列 NM_000369 NM_001113404
蛋白序列 NP_000360 NP_001106875
基因位置 Chr 14:
81.42 – 81.61 Mb
Chr 12:
91.4 – 91.54 Mb
PubMed查询 [1] [2]

促甲状腺激素受体英语thyrotropin receptorTSH receptorTSHR)是一种接受促甲状腺激素(thyrotropin)信号,刺激细胞生成甲状腺激素(T4)和三碘甲状腺激素(T3)的跨膜受体。TSHR是膜内在蛋白英语Integral membrane proteinG蛋白偶联受体超家族的一员[1],与Gs蛋白英语Gs alpha subunit相连接[2]

该受体主要出现在甲状腺上皮细胞英语thyroid epithelial cell的表面。

功能[编辑]

Upon binding circulating thyrotropin, a G-protein signal cascade activates adenylyl cyclase and intercellular levels of cAMP rise. cAMP activates all functional aspects of the thyroid cell, including iodine pumping; thyroglobulin synthesis, iodination, endocytosis and proteolysis; thyroid peroxidase activity; and hormone release.

另见[编辑]

参考文献[编辑]

  1. ^ Farid NR, Szkudlinski MW. Minireview: structural and functional evolution of the thyrotropin receptor. Endocrinology. 2004, 145 (9): 4048–57. doi:10.1210/en.2004-0437. PMID 15231707. 
  2. ^ Calebiro D, Nikolaev VO, Lohse MJ. Imaging of persistent cAMP signaling by internalized G protein-coupled receptors. J. Mol. Endocrinol. July 2010, 45 (1): 1–8. doi:10.1677/JME-10-0014. PMID 20378719. 

延伸阅读[编辑]

  • Führer D, Wonerow P, Willgerodt H, Paschke R. Identification of a new thyrotropin receptor germline mutation (Leu629Phe) in a family with neonatal onset of autosomal dominant nonautoimmune hyperthyroidism.. J. Clin. Endocrinol. Metab. 1998, 82 (12): 4234–8. doi:10.1210/jc.82.12.4234. PMID 9398746. 
  • Farid NR, Kascur V, Balazs C. The human thyrotropin receptor is highly mutable: a review of gain-of-function mutations.. Eur. J. Endocrinol. 2000, 143 (1): 25–30. doi:10.1530/eje.0.1430025. PMID 10870027. 
  • Szkudlinski MW, Fremont V, Ronin C, Weintraub BD. Thyroid-stimulating hormone and thyroid-stimulating hormone receptor structure-function relationships.. Physiol. Rev. 2002, 82 (2): 473–502. doi:10.1152/physrev.00031.2001. PMID 11917095. 
  • Tonacchera M, Vitti P, De Servi M, et al.. Gain of function TSH receptor mutations and iodine deficiency: implications in iodine prophylaxis.. J. Endocrinol. Invest. 2004, 26 (2 Suppl): 2–6. PMID 12762632. 
  • Arturi F, Scarpelli D, Coco A, et al.. Thyrotropin receptor mutations and thyroid hyperfunctioning adenomas ten years after their first discovery: unresolved questions.. Thyroid. 2004, 13 (4): 341–3. doi:10.1089/105072503321669811. PMID 12804102. 
  • Vaidya B, Campbell V, Tripp JH, et al.. Premature birth and low birth weight associated with nonautoimmune hyperthyroidism due to an activating thyrotropin receptor gene mutation.. Clin. Endocrinol. (Oxf). 2004, 60 (6): 711–8. doi:10.1111/j.1365-2265.2004.02040.x. PMID 15163335. 
  • Takeshita A, Nagayama Y, Fujiyama K, et al.. Molecular cloning and sequencing of an alternatively spliced form of the human thyrotropin receptor transcript.. Biochem. Biophys. Res. Commun. 1992, 188 (3): 1214–9. doi:10.1016/0006-291X(92)91360-3. PMID 1445355. 
  • Graves PN, Tomer Y, Davies TF. Cloning and sequencing of a 1.3 KB variant of human thyrotropin receptor mRNA lacking the transmembrane domain.. Biochem. Biophys. Res. Commun. 1992, 187 (2): 1135–43. doi:10.1016/0006-291X(92)91315-H. PMID 1530609. 
  • Loosfelt H, Pichon C, Jolivet A, et al.. Two-subunit structure of the human thyrotropin receptor. Proc. Natl. Acad. Sci. U.S.A. 1992, 89 (9): 3765–9. doi:10.1073/pnas.89.9.3765. PMC 525571. PMID 1570295. 
  • Nagayama Y, Russo D, Wadsworth HL, et al.. Eleven amino acids (Lys-201 to Lys-211) and 9 amino acids (Gly-222 to Leu-230) in the human thyrotropin receptor are involved in ligand binding. J. Biol. Chem. 1991, 266 (23): 14926–30. PMID 1651314. 
  • Murakami M, Mori M. Identification of immunogenic regions in human thyrotropin receptor for immunoglobulin G of patients with Graves' disease. Biochem. Biophys. Res. Commun. 1990, 171 (1): 512–8. doi:10.1016/0006-291X(90)91423-P. PMID 1697467. 
  • Heldin NE, Gustavsson B, Westermark K, Westermark B. A somatic point mutation in a putative ligand binding domain of the TSH receptor in a patient with autoimmune hyperthyroidism. J. Clin. Endocrinol. Metab. 1992, 73 (6): 1374–6. doi:10.1210/jcem-73-6-1374. PMID 1955520. 
  • Libert F, Passage E, Lefort A, et al.. Localization of human thyrotropin receptor gene to chromosome region 14q3 by in situ hybridization. Cytogenet. Cell Genet. 1991, 54 (1–2): 82–3. doi:10.1159/000132964. PMID 2249482. 
  • Frazier AL, Robbins LS, Stork PJ, et al.. Isolation of TSH and LH/CG receptor cDNAs from human thyroid: regulation by tissue specific splicing. Mol. Endocrinol. 1991, 4 (8): 1264–76. doi:10.1210/mend-4-8-1264. PMID 2293030. 
  • Misrahi M, Loosfelt H, Atger M, et al.. Cloning, sequencing and expression of human TSH receptor. Biochem. Biophys. Res. Commun. 1990, 166 (1): 394–403. doi:10.1016/0006-291X(90)91958-U. PMID 2302212. 
  • Nagayama Y, Kaufman KD, Seto P, Rapoport B. Molecular cloning, sequence and functional expression of the cDNA for the human thyrotropin receptor. Biochem. Biophys. Res. Commun. 1990, 165 (3): 1184–90. doi:10.1016/0006-291X(89)92727-7. PMID 2558651. 
  • Libert F, Lefort A, Gerard C, et al.. Cloning, sequencing and expression of the human thyrotropin (TSH) receptor: evidence for binding of autoantibodies. Biochem. Biophys. Res. Commun. 1990, 165 (3): 1250–5. doi:10.1016/0006-291X(89)92736-8. PMID 2610690. 
  • Cuddihy RM, Bryant WP, Bahn RS. Normal function in vivo of a homozygotic polymorphism in the human thyrotropin receptor. Thyroid. 1996, 5 (4): 255–7. doi:10.1089/thy.1995.5.255. PMID 7488864. 
  • Bahn RS, Dutton CM, Heufelder AE, Sarkar G. A genomic point mutation in the extracellular domain of the thyrotropin receptor in patients with Graves' ophthalmopathy. J. Clin. Endocrinol. Metab. 1994, 78 (2): 256–60. doi:10.1210/jc.78.2.256. PMID 7508946. 
  • Sunthornthepvarakui T, Gottschalk ME, Hayashi Y, Refetoff S. Brief report: resistance to thyrotropin caused by mutations in the thyrotropin-receptor gene. N. Engl. J. Med. 1995, 332 (3): 155–60. doi:10.1056/NEJM199501193320305. PMID 7528344. 

外部链接[编辑]