克罗莫结构域

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克罗莫结构域
PDB 1pfb EBI.jpg
多梳克罗莫结构域的结构[1]
鉴定
标志 Chromodomain
Pfam(蛋白家族查询站) PF00385
InterPro(蛋白数据整合站) IPR000953
SMART SM00298
PROSITE(蛋白数据站) PS50013
SCOP(蛋白结构分类数据站) 1pfb
CDD(保守域数据站) cd00024

克罗莫结构域英语Chromodomainchromatin organization modifier[2])是一种由40~50个氨基酸残基组成的蛋白质结构域,往往存在于那些与染色质重塑及操控有关的蛋白质里。此结构域不管在植物及动物之中都高度保守,且在许多基因组(如小鼠)中代表了较大数量的各种蛋白质。许多包含克罗莫结构域的基因有多种可变剪接亚型,有些亚型完全把克罗莫结构域当作内含子切除出去[3]。在哺乳动物中,包含克罗莫结构域的蛋白质主要负责涉及到染色质重塑及形成异染色质区域这两方面的基因调控[4]。包含克罗莫结构域的蛋白质亦会结合到甲基化组蛋白[5][6]且存在于RNA诱导的转录沉默复合物中[7]

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参考文献[编辑]

  1. ^ Min J, Zhang Y, Xu RM. Structural basis for specific binding of Polycomb chromodomain to histone H3 methylated at Lys 27. Genes Dev. 2003-08, 17 (15): 1823–8. doi:10.1101/gad.269603. PMC 196225. PMID 12897052. 
  2. ^ S Messmer, A Franke, R Paro. Analysis of the functional role of the Polycomb chromo domain in Drosophila melanogaster. Genes Dev. 1992-07, 6 (7): 1241–1254. doi:10.1101/gad.6.7.1241. PMID 1628830. 
  3. ^ Tajul-Arifin, K, Teasdale, R, Ravasi, T, Humel, DA, Group, RIKEN GER, Members, GSL, Mattick, JS. Identification and Analysis of Chromodomain-Containing Proteins Encoded in the Mouse Transcriptome. Genome Res. 2003, 13 (6B): 1416–1429. doi:10.1101/gr.1015703. PMC 403676. PMID 12819141. 
  4. ^ Jones, DO, Cowell, IG, Singh, PB. Mammalian chromodomain proteins: their role in genome organisation and expression. Bioessays. 2000, 22 (2): 124–37. doi:10.1002/(SICI)1521-1878(200002)22:2<124::AID-BIES4>3.0.CO;2-E. PMID 10655032. 
  5. ^ Nielsen, PR, Nietlispach, D, Mott, HR, Callaghan, J, Bannister, A, Kouzarides, T, Murzin, AG, Murzina, NV et al. Structure of the HP1 chromodomain bound to histone H3 methylated at lysine 9. Nature. 2002, 416 (6876): 103–7. doi:10.1038/nature722. PMID 11882902. 
  6. ^ Jacobs, SA, Khorasanizadeh, S. Structure of HP1 chromodomain bound to a lysine 9-methylated histone H3 tail. Science. 2002, 295 (5562): 2080–3. doi:10.1126/science.1069473. PMID 11859155. 
  7. ^ Verdel, A, Jia, S, Gerber, S, Sugiyama, T, Gygi, S, Grewal, S, Moazed, D. RNAi-Mediated Targeting of Heterochromatin by the RITS Complex. Science. 2004, 303 (5658): 672–6. doi:10.1126/science.1093686. PMC 3244756. PMID 14704433. 

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