凝血酶

维基百科,自由的百科全书
跳转至: 导航搜索
凝血因子II(凝血酶)

人类凝血酶结构,与其抑制剂水蛭素结合在一起[1]
有效结构
PDB 直系同源检索:PDBe, RCSB
标识
代号 F2; PT
扩展标识 遗传学176930 鼠基因88380 同源基因426 GeneCards: F2 Gene
EC編號 3.4.21.5
RNA表达模式
PBB GE F2 205754 at tn.png
更多表达数据
直系同源体
物种 人类 鼠类
Entrez 2147 14061
Ensembl ENSG00000180210 ENSMUSG00000027249
UniProt P00734 Q3TJ94
mRNA序列 NM_000506 NM_010168
蛋白序列 NP_000497 NP_034298
基因位置 Chr 11:
46.7 – 46.72 Mb
Chr 2:
91.43 – 91.44 Mb
PubMed查询 [2] [3]

凝血酶[2]英语ThrombinEC 3.4.21.5)是一种“胰蛋白酶样”丝氨酸蛋白酶蛋白质,在人体中被F2基因所编码[3][4]。在凝血作用第一级级联反应中,凝血酶原凝血因子Ⅱ)被蛋白水解性切除以生成凝血酶,级联反应最终阻止了血液的继续流失。凝血酶转而作为一种丝氨酸蛋白酶以使可溶性的纖維蛋白原转变为不溶性的纖維蛋白,同时催化其他许多与凝血相关的反应。

另见[编辑]

参考文献[编辑]

  1. ^ PDB 2C93; Howard N, Abell C, Blakemore W, Chessari G, Congreve M, Howard S, Jhoti H, Murray CW, Seavers LC, van Montfort RL. Application of fragment screening and fragment linking to the discovery of novel thrombin inhibitors. J. Med. Chem. 2006.February, 49 (4): 1346–55. doi:10.1021/jm050850v. PMID 16480269. 
  2. ^ [1]
  3. ^ Royle NJ, Irwin DM, Koschinsky ML, MacGillivray RT, Hamerton JL. Human genes encoding prothrombin and ceruloplasmin map to 11p11-q12 and 3q21-24, respectively. Somat. Cell Mol. Genet. 1987.May, 13 (3): 285–92. doi:10.1007/BF01535211. PMID 3474786. 
  4. ^ Degen SJ, Davie EW. Nucleotide sequence of the gene for human prothrombin. Biochemistry. 1987.September, 26 (19): 6165–77. doi:10.1021/bi00393a033. PMID 2825773. 

深入阅读[编辑]

  • Esmon CT. Thrombomodulin as a model of molecular mechanisms that modulate protease specificity and function at the vessel surface. FASEB J. 1995, 9 (10): 946–55. PMID 7615164. 
  • Lenting PJ, van Mourik JA, Mertens K. The life cycle of coagulation factor VIII in view of its structure and function. Blood. 1999, 92 (11): 3983–96. PMID 9834200. 
  • Plow EF, Cierniewski CS, Xiao Z, et al.. AlphaIIbbeta3 and its antagonism at the new millennium. Thromb. Haemost. 2002, 86 (1): 34–40. PMID 11487023. 
  • Maragoudakis ME, Tsopanoglou NE, Andriopoulou P. Mechanism of thrombin-induced angiogenesis. Biochem. Soc. Trans. 2002, 30 (2): 173–7. doi:10.1042/BST0300173. PMID 12023846. 
  • Howell DC, Laurent GJ, Chambers RC. Role of thrombin and its major cellular receptor, protease-activated receptor-1, in pulmonary fibrosis. Biochem. Soc. Trans. 2002, 30 (2): 211–6. doi:10.1042/BST0300211. PMID 12023853. 
  • Firth SM, Baxter RC. Cellular actions of the insulin-like growth factor binding proteins. Endocr. Rev. 2003, 23 (6): 824–54. doi:10.1210/er.2001-0033. PMID 12466191. 
  • Minami T, Sugiyama A, Wu SQ, et al.. Thrombin and phenotypic modulation of the endothelium. Arterioscler. Thromb. Vasc. Biol. 2004, 24 (1): 41–53. doi:10.1161/01.ATV.0000099880.09014.7D. PMID 14551154. 
  • De Cristofaro R, De Candia E. Thrombin domains: structure, function and interaction with platelet receptors. J. Thromb. Thrombolysis. 2004, 15 (3): 151–63. doi:10.1023/B:THRO.0000011370.80989.7b. PMID 14739624. 
  • Tsopanoglou NE, Maragoudakis ME. Role of thrombin in angiogenesis and tumor progression. Semin. Thromb. Hemost. 2004, 30 (1): 63–9. doi:10.1055/s-2004-822971. PMID 15034798. 
  • Bode W. Structure and interaction modes of thrombin. Blood Cells Mol. Dis. 2007, 36 (2): 122–30. doi:10.1016/j.bcmd.2005.12.027. PMID 16480903. 
  • Wolberg AS. Thrombin generation and fibrin clot structure. Blood Rev. 2007, 21 (3): 131–42. doi:10.1016/j.blre.2006.11.001. PMID 17208341. 
  • Degen S: Prothrombin. In: High K, Roberts H, eds. Molecular Basis of Thrombosis and Hemostasis. New York, NY: Marcel Dekker; 1995:75.

外部链接[编辑]

Template:凝固作用