双氯芬酸钠

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双氯芬酸钠
IUPAC命名
2-(2-(2,6-dichlorophenylamino)phenyl)acetic acid
識別
CAS號 15307-86-5
ATC編碼 M01AB05 M02AA15, S01BC03
PubChem CID 3033
DrugBank APRD00527
ChemSpider 2925
化學性質
化學式 C14H11Cl2NO2 
分子量 296.148 g/mol
SMILES 搜尋Jmol 3D模型eMoleculesPubChem
药代动力学性質
生物利用度 100%
蛋白結合 >99%
代謝 hepatic, no active metabolites exist
半衰期 1.2-2 hr (35% of the drug enters enterohepatic recirculation)
排泄 biliary, only 1% in urine
治療考量
懷孕分級 A () B (1st. and 2nd. trimenon), X (third trimenon)
合法狀態 POM () Rx-only most preparations/countries. Limited OTC some countries. Manufacture and veterinary use is banned in India, Nepal and Pakistan due to imminent extinction of local vultures.
途徑 oral, rectal, im, iv (renal- and gallstones), topical

双氯芬酸钠DiclofenacDiclofenac potassium)是一种衍生于苯乙酸类非類固醇消炎止痛藥。本药用于骨节炎骨膜炎骨骼肌炎关节炎痛风风湿

一般建議用美洛昔康(Meloxicam)來代替双氯芬酸钠。因Diclofenac除了在人體使用會產生副作用外、也來自於禿鷹吃了食用Diclofenac的家畜後所造成禿鷹死亡等案例之影響。[1]

作用机制[编辑]

其作用机理为抑制环氧化酶活性从而阻断花生四烯酸前列腺素的转化生成,因前列腺素為引起疼痛、發燒及發炎等之現象的主要因子。

成藥[编辑]

食用[编辑]

成年人每日推荐剂量为每次两十五到五十毫克每日三次,每日最大用量一百五十毫克。小儿本药只能在医生指导下服用。小儿只能注射服用。

外用凝膠劑[编辑]

僅為外用作為一般酸痛凝膠劑,每公克約含Diclofenac Sodium 10mg。具有消炎、抗風濕、止痛,及解熱等作用。每日3~4次;每次2~4公克。小儿、孕婦、授乳婦等使用本药建議在医生或藥師、藥劑生指导下使用,不建議自行使用。

肛門塞劑[编辑]

肛門塞劑,腸溶錠劑型,其主要有消炎、鎮痛及解熱作用。Voren (台灣 永信藥品)。

成藥商標[编辑]

  • Arthrotec:加入Misoprostol合用。
  • Voren (台灣)
  • 诺华:Voltaren扶他林(加拿大,中国大陆)

禁忌[编辑]

患有胃溃疡、十二指肠溃疡、血友病、肝病、心病、肾病者禁用。本药孕妇禁用。服药期间出现过敏、恶心、泻肚困难时应立即就医。

商標名稱[编辑]

藥品的商業名稱包括:

  • Aclonac Emulsi Gel
  • A-fenac (Bangladesh)
  • Abitren
  • Acteric (Costa Rica)
  • Almiral
  • Anaflex (Argentina)
  • Anuva
  • Arthrotec (combination with misoprostol)
  • Artifen (Pakistan Abbott Laboratories LTD)
  • Befol
  • Berifen
  • Betaren
  • Bufenac Forte
  • Cambia
  • Cataflam
  • Catafast
  • Caflam (Pakistan)
  • Clafen
  • Clofast
  • Clonac
  • Dedolor
  • Deflamat
  • Deflox
  • Dici K (diclofenac potassium, India)
  • Diclac
  • Diclo M (India & Myanmar) V.I.P Pharma
  • Dicloberl
  • Diclobene
  • Diclo-Denk (Germany)
  • Diclofenac
  • Diclofenac-Asteria (USA and Korea)
  • Diclofenaco Normon (Spain)
  • Diclofenacum
  • Dicloflam (South Africa)
  • Dicloflex
  • Diclogem
  • Diclogesic (Jordan and Romania)
  • Diclohexal
  • Diclon
  • Diclomar (Argentina)
  • Diclomex (Finland)
  • Dicloran (Malaysia)
  • Diclowin Plus (India)
  • Diclon
  • Diclopar (Tanzania)
  • Diclotab (Laos)
  • Diklofenak T Actavis (Sweden)
  • Difen
  • Difenac (Venezuela)
  • Difene
  • Difnal (Malaysia)
  • Dinac (Nepal)
  • Dioxaflex (Latin America, Central America)
  • Disflam K (diclofenac potassium, Central America)
  • Dolex
  • Dolphin (Egypt)
  • Dolmina (Czech Republic)
  • Dyloject
  • Feloran
  • Fenac (diclofenac potassium, Australia)
  • Flamrase
  • Flector Patch
  • Flogozan (Mexico)
  • Idinac (India)
  • Immunagel (India)
  • Iodex UltraGel (India)
  • Kemoren (Indonesia)
  • Klodifen
  • Modifenac
  • Morbidic (India)
  • Motifene
  • Naklofen
  • Neofenac (Bangladesh)
  • Neopyrazon (United Laboratories, ASIA)
  • Oflam
  • Olfen
  • Ortofen
  • Phlogin - Diclofenac Sodium (Pakistan)
  • Panamor
  • Parazone-DP (combination of Paracetamol & Diclofenac potassium)
  • Pennsaid
  • Pritaren
  • Rapidus
  • Rapten-K
  • Reactin (India)
  • Rhumalgan
  • Rofenac (Middle East)
  • Rufenal
  • Safeguard (combination with misoprostol)
  • Sandoz (diclofenac sodium, Australia)
  • Solaraze
  • Seradic (India)
  • Topac
  • Trabona
  • Tratul (Austria, Romania, Moldova)
  • Uno
  • Veltex CR (South Africa)
  • Vetagesic
  • Viclofen (Australia)
  • Vinil (Paraguay)
  • Voldic
  • Volini (India)
  • Volfenac (Thailand)
  • Volna-k (Taiwan)
  • Voltaflam (India)
  • Voltaren (Argentina, Australia, Belgium, Egypt, France, Germany, Israel, New Zealand, Norway, Portugal, Russia, South Africa, Sweden, Turkey)
  • Voltaren Emulgel (Australia, Canada, New Zealand, UK)
  • Voltaren Gel (US)
  • Voltarol
  • Voltarol Emulgel
  • Voltarol Pain-eze
  • Voltfast
  • Voren (Taiwan)
  • Voltral (UK, Pakistan)
  • Votrex
  • Vostar
  • Votalin (China)
  • Voveran
  • Vurdon
  • Zipsor
  • Zolterol
  • Zorvolex-free acid diclofenac
  • Zengesic (combination of Paracetamol & Diclofenac sodium)
  • Hitflam (Ambee Pharmaceuticals Ltd. Bangladesh)

註釋[编辑]

  1. ^ "Vet drug 'killing Asian vultures'", BBC News,28 January 2004, webpage:BBC583. (英文)

外部連結[编辑]

Template:Anti-inflammatory and antirheumatic products Template:Topical products for joint and muscular pain