延胡索酸酶[3]（英语：Fumarase，亦称为延胡索酸水合酶，EC 4.2.1.2）属于柠檬酸循环中的一种酶，主要催化延胡索酸水和形成L-苹果酸。该酶的催化反应是可逆的，但具有严格的立体选择性，水裂解的羟基被严格地加到延胡索酸分子双键的一侧，而氢被加到另一侧。故正反应中只催化反式双键（延胡索酸）的水化，而不能催化马来酸， 而逆反应只催化形成苹果酸的L-异构体。
参考文献 [编辑]
- ^ 1.0 1.1 Based on PDB 1yfm coordinates; Weaver T, Lees M, Zaitsev V, Zaitseva I, Duke E, Lindley P, McSweeny S, Svensson A, Keruchenko J, Keruchenko I, Gladilin K, Banaszak L. Crystal structures of native and recombinant yeast fumarase. J. Mol. Biol. 1998.July, 280 (3): 431–42. doi:10.1006/jmbi.1998.1862. PMID 9665847.
- ^ 2.0 2.1 Figure rendered using UCSF Chimera. Molecular graphics images were produced using the UCSF Chimera package from the Resource for Biocomputing, Visualization, and Informatics at the University of California, San Francisco; Pettersen EF, Goddard TD, Huang CC, Couch GS, Greenblatt DM, Meng EC, Ferrin TE. UCSF Chimera--a visualization system for exploratory research and analysis. J Comput Chem. 2004.October, 25 (13): 1605–12. doi:10.1002/jcc.20084. PMID 15264254.
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