无机焦磷酸酶（英语：Inorganic Pyrophosphatase，简称为焦磷酸酶）是一种催化一分子焦磷酸盐转化为两分子磷酸盐离子的酶[1]。这是一个高放能的反应，因此此反应可偶联到一些热力学上不利的转化，以便驱动这些转化进行到完全[2]。此酶的功能乃是在脂代谢（包括脂合成与讲解）、钙吸收以及骨形成[3][4]和DNA合成[5]中扮演重要角色，其他生物化学转化也是如此[6][7]。
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参考文献[编辑]
- ^ Harold FM. Inorganic polyphosphates in biology: structure, metabolism, and function. Bacteriol Rev. 1966.December, 30 (4): 772–94. PMC 441015. PMID 5342521.
- ^ Terkeltaub RA. Inorganic pyrophosphate generation and disposition in pathophysiology. Am. J. Physiol., Cell Physiol. 2001.July, 281 (1): C1–C11. PMID 11401820.
- ^ Orimo H, Ohata M, Fujita T. Role of inorganic pyrophosphatase in the mechanism of action of parathyroid hormone and calcitonin. Endocrinology. 1971.September, 89 (3): 852–8. doi:10.1210/endo-89-3-852. PMID 4327778.
- ^ Poole KE, Reeve J. Parathyroid hormone - a bone anabolic and catabolic agent. Curr Opin Pharmacol. 2005.December, 5 (6): 612–7. doi:10.1016/j.coph.2005.07.004. PMID 16181808.
- ^ Nelson, David L.; Cox, Michael M. Lehninger Principles of Biochemistry, 3rd ed.. New York: Worth Publishers. 2000: 937. ISBN 1-57259-153-6.
- ^ Ko KM, Lee W, Yu JR, Ahnn J. PYP-1, inorganic pyrophosphatase, is required for larval development and intestinal function in C. elegans. FEBS Lett. 2007.November, 581 (28): 5445–53. doi:10.1016/j.febslet.2007.10.047. PMID 17981157.
- ^ Usui Y, Uematsu T, Uchihashi T, et al.. Inorganic polyphosphate induces osteoblastic differentiation. J. Dent. Res. 2010.May, 89 (5): 504–9. doi:10.1177/0022034510363096. PMID 20332330.
