模式识别受体

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模式识别受体免疫系统细胞表达的,与病原微生物或细胞应激相关的蛋白。可以被模式识别受体识别的微生物特定分子为病原相关分子模式。包括细菌的碳水化合物(如脂多糖甘露糖);革兰氏阳性菌的肽聚糖和脂磷壁酸,及真菌多糖.

根据其功能,模式识别受体可分为细胞内吞噬受体或信号受体。信号受体包括细胞膜连的Toll样受体[1]及胞浆内NOD样受体。内吞噬受体促进吞噬细胞对微生物的附着,吞噬和破坏,而不传道细胞信号。

分类[编辑]

膜连受体[编辑]

胞浆内的模式识别受体[编辑]

分泌的模式识别受体[编辑]


参考文献[编辑]

  1. ^ Beutler et al. GENETIC ANALYSIS OF HOST RESISTANCE: Toll-Like Receptor Signaling and Immunity at Large. Annual Review of Immunology Volume 24, pages 353-389.
  2. ^ Apostolopoulos and McKenzie. Role of the Mannose Receptor in the Immune Response. Current Molecular Medicine 2001, Volume 1, pages 469-474.
  3. ^ Ting JP, Williams KL. The CATERPILLER family: an ancient family of immune/apoptotic proteins. Clinical Immunology, 2005, Volume 115(1):33-7.
  4. ^ Strober et al., Signalling pathways and molecular interactions of NOD1 and NOD2. Nat Rev Immunol. 2006, Volume 6(1):9-20.
  5. ^ Dommett et al., Mannose-binding lectin in innate immunity: past, present and future. Tissue Antigens, 2006, Volume 68 Issue 3 Page 193