粉色麵包黴菌
维基百科,自由的百科全书
|
粉色麵包黴菌 Neurospora crassa |
||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 科學分類 | ||||||||||||||
|
||||||||||||||
| 二名法 | ||||||||||||||
| Neurospora crassa Shear & B.O. Dodge |
粉色麵包黴菌(Neurospora crassa,又譯紅麵包黴菌等)是一種屬於子囊菌門(Ascomycota)的黴菌。由於生長容易,且擁有單倍體世代,使隱性遺傳可直接展現,進而使遺傳學分析較為簡易,因此是一種生物學上的模式生物。
N. crassa的早期研究者喬治·比德爾(George Wells Beadle)與愛德華·塔特姆(Edward Tatum),在實驗中利用X射線照射使N. crassa發生突變,進而觀察到因酵素失效而遭破壞的生化代謝途徑,並由此確立了基因編碼與蛋白質的關係。兩人因此獲得諾貝爾生理學或醫學獎。
N. crassa擁有7條染色體,完整的基因組已經大致定序完成[1]。並於2003年4月24日發表於《自然》期刊。其基因組大小約43Mb,含有約1萬個基因。目前正在進行每一個基因的敲除(knockout)測試。
參考文獻 [编辑]
- Perkins, D; Davis, Evidence for Safety of Neurospora Species for Academic and Commercial Uses, APPLIED AND ENVIRONMENTAL MICROBIOLOGY. 2000, 66 (12):5107-5109. PMID 11097875
- Osherov, N; May, The molecular mechanisms of conidial germination, FEMS Microbiol Lett. 2001, 199(2):153-60. PMID 11377860
- Froehlich, AC; Noh; Vierstra, Genetic and molecular analysis of Phytochromes from the filamentous fungus Neurospora crassa, Eukaryot Cell. 2005, 4(12):2140-52. PMID 16339731
- Horowitz, NH, NH, Fifty years ago: the Neurospora revolution, Genetics. 1991. PMID 1827628
- Horowitz, NH; Berg; Singer, A centennial: George W. Beadle, 1903-1989, Genetics. 2004, 166(1):1-10. PMID 15020400
- Kaldi, K; Gonzalez; Brunner, Transcriptional regulation of the Neurospora circadian clock gene wc-1 affects the phase of circadian output, EMBO Rep. 2005. PMID 16374510
- Pittalwala, Iqbal, Iqbal, UC Riverside scientists contribute to study that unveils genome sequence of bread mold, Newsroom (University of California, Riverside). 2003.
- Ruoff, P, The relationship between FRQ-protein stability and temperature compensation in the Neurospora circadian clock, Proc Natl Acad Sci USA. 2005. PMID 16314576
外部連結 [编辑]
| 维基共享资源中相关的多媒体资源:粉色麵包黴菌 |
- Neurospora crassa 基因組 [1]
- The Neurospora Homepage. Fungal Genetics Stock Center (FGSC). [December 27]. 已忽略未知参数
|accessyear=(帮助) - The Neurospora Compendium. Fungal Genetics Stock Center (FGSC). [December 27]. 已忽略未知参数
|accessyear=(帮助) - The Neurospora-Fungal Genome Initiative. Neurospora Genome Project. [December 28]. 已忽略未知参数
|accessyear=(帮助) - Trans-NIH Neurospora Initiative. National Institutes of Health (NIH — United States). [December 27]. 已忽略未知参数
|accessyear=(帮助)