細胞色素c

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細胞色素c,體細胞

血紅素及細胞色素c
有效结构
PDB 直系同源检索:PDBe, RCSB
标识
代号 CYCS; HCS; CYC
扩展标识 遗传学123970 鼠基因88578 同源基因68675 GeneCards: CYCS Gene
RNA表达模式
PBB GE CYCS 208905 at tn.png
更多表达数据
直系同源体
物种 人类 鼠类
Entrez 54205 13063
Ensembl ENSG00000172115 n/a
UniProt P99999 n/a
mRNA序列 NM_018947 XM_975140
蛋白序列 NP_061820 XP_980234
基因位置 Chr 7:
25.12 – 25.13 Mb
n/a
PubMed查询 [1] [2]

細胞色素c英语cytochrome c, cyt c)或稱細胞色素複合體英语cytochrome complex),是一種血紅素蛋白,屬於cytochrome c family英语。細胞色素c會與粒線體內膜輕微連接,結構鬆散而微小的它和其他細胞色素不同,是一種高度可溶性蛋白,在水中的可溶性達每公升100克。細胞色素c是電子傳遞鏈不可或缺的元件,負責攜帶一粒電子,在複合物III複合物IV之間傳遞。此外,它能夠接受氧化還原反應,但不與結合。在人體中,細胞色素c已經由CYCS基因完成編碼[1][2]

細胞色素c和細胞程序性死亡有關[3]

交互作用[编辑]

細胞色素c被證實會和COX4I2進行交互作用[4][5][6][7]

參考資料[编辑]

  1. ^ Entrez Gene: cytochrome c. NCBI. 2011-06-18 (英文). 
  2. ^ Tafani, M; Karpinich, N. O.; Hurster, K. A.; Pastorino, J. G.; Schneider, T; Russo, M. A.; Farber, J. L. Cytochrome c release upon Fas receptor activation depends on translocation of full-length bid and the induction of the mitochondrial permeability transition. Journal of Biological Chemistry. 2002, 277 (12): 10073–82. doi:10.1074/jbc.M111350200. PMID 11790791.  编辑
  3. ^ 新世紀生命科學課程改進計畫:神經生物學 第一章. 國立陽明大學生命科學院. [2011-07-02]. 
  4. ^ Michel, B; Bosshard H R. Spectroscopic analysis of the interaction between cytochrome c and cytochrome c oxidase. J. Biol. Chem. (UNITED STATES). 1984-Aug., 259 (16): 10085–91. ISSN 0021-9258. PMID 6088481 (英文). 
  5. ^ Wiedemann, F R; Vielhaber S, Schröder R, Elger C E, Kunz W S. Evaluation of methods for the determination of mitochondrial respiratory chain enzyme activities in human skeletal muscle samples. Anal. Biochem. (UNITED STATES). 2000-Mar., 279 (1): 55–60. doi:10.1006/abio.1999.4434. ISSN 0003-2697. PMID 10683230 (英文). 
  6. ^ Sampson, V; Alleyne T. Cytochrome c/cytochrome c oxidase interaction. Direct structural evidence for conformational changes during enzyme turnover. Eur. J. Biochem. (Germany). 2001-Dec., 268 (24): 6534–44. doi:10.1046/j.0014-2956.2001.02608.x. ISSN 0014-2956. PMID 11737208 (英文). 
  7. ^ Lynch, S R; Sherman D, Copeland R A. Cytochrome c binding affects the conformation of cytochrome a in cytochrome c oxidase. J. Biol. Chem. (UNITED STATES). 1992-Jan., 267 (1): 298–302. ISSN 0021-9258. PMID 1309738 (英文). 

延伸閱讀[编辑]

  • Kumarswamy, R; Chandna, S. Putative partners in Bax mediated cytochrome-c release: ANT, CypD, VDAC or none of them?. Mitochondrion. 2009, 9 (1): 1–8. doi:10.1016/j.mito.2008.10.003. PMID 18992370.  编辑
  • Skulachev, V. P. Cytochrome c in the apoptotic and antioxidant cascades. FEBS letters. 1998, 423 (3): 275–80. PMID 9515723.  编辑
  • Mannella, C. A. Conformational changes in the mitochondrial channel protein, VDAC, and their functional implications. Journal of Structural Biology. 1998, 121 (2): 207–18. doi:10.1006/jsbi.1997.3954. PMID 9615439.  编辑
  • Ferri, K. F.; Jacotot, E; Blanco, J; Esté, J. A.; Kroemer, G. Mitochondrial control of cell death induced by HIV-1-encoded proteins. Annals of the New York Academy of Sciences. 2000, 926: 149–64. PMID 11193032.  编辑
  • Britton, R. S.; Leicester, K. L.; Bacon, B. R. Iron toxicity and chelation therapy. International journal of hematology. 2002, 76 (3): 219–28. PMID 12416732.  编辑
  • Haider, N; Narula, N; Narula, J. Apoptosis in heart failure represents programmed cell survival, not death, of cardiomyocytes and likelihood of reverse remodeling. Journal of Cardiac Failure. 2002, 8 (6 Suppl): S512–7. doi:10.1054/jcaf.2002.130034. PMID 12555167.  编辑
  • Castedo, M; Perfettini, J. L.; Andreau, K; Roumier, T; Piacentini, M; Kroemer, G. Mitochondrial apoptosis induced by the HIV-1 envelope. Annals of the New York Academy of Sciences. 2003, 1010: 19–28. PMID 15033690.  编辑
  • Ng, S; Smith, M. B.; Smith, H. T.; Millett, F. Effect of modification of individual cytochrome c lysines on the reaction with cytochrome b5. Biochemistry. 1977, 16 (23): 4975–8. PMID 199233.  编辑
  • Lynch, S. R.; Sherman, D; Copeland, R. A. Cytochrome c binding affects the conformation of cytochrome a in cytochrome c oxidase. The Journal of biological chemistry. 1992, 267 (1): 298–302. PMID 1309738.  编辑
  • Garber, E. A.; Margoliash, E. Interaction of cytochrome c with cytochrome c oxidase: An understanding of the high- to low-affinity transition. Biochimica et biophysica acta. 1990, 1015 (2): 279–87. PMID 2153405.  编辑
  • Bedetti, C. D. Immunocytochemical demonstration of cytochrome c oxidase with an immunoperoxidase method: A specific stain for mitochondria in formalin-fixed and paraffin-embedded human tissues. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 1985, 33 (5): 446–52. PMID 2580882.  编辑
  • Tanaka, Y; Ashikari, T; Shibano, Y; Amachi, T; Yoshizumi, H; Matsubara, H. Construction of a human cytochrome c gene and its functional expression in Saccharomyces cerevisiae. Journal of biochemistry. 1988, 103 (6): 954–61. PMID 2844747.  编辑
  • Evans, M. J.; Scarpulla, R. C. The human somatic cytochrome c gene: Two classes of processed pseudogenes demarcate a period of rapid molecular evolution. Proceedings of the National Academy of Sciences of the United States of America. 1988, 85 (24): 9625–9. PMC 282819. PMID 2849112.  编辑
  • Passon, P. G.; Hultquist, D. E. Soluble cytochrome b 5 reductase from human erythrocytes. Biochimica et biophysica acta. 1972, 275 (1): 62–73. PMID 4403130.  编辑
  • Dowe, R. J.; Vitello, L. B.; Erman, J. E. Sedimentation equilibrium studies on the interaction between cytochrome c and cytochrome c peroxidase. Archives of biochemistry and biophysics. 1984, 232 (2): 566–73. PMID 6087732.  编辑
  • Michel, B; Bosshard, H. R. Spectroscopic analysis of the interaction between cytochrome c and cytochrome c oxidase. The Journal of biological chemistry. 1984, 259 (16): 10085–91. PMID 6088481.  编辑
  • Broger, C; Nałecz, M. J.; Azzi, A. Interaction of cytochrome c with cytochrome bc1 complex of the mitochondrial respiratory chain. Biochimica et biophysica acta. 1980, 592 (3): 519–27. PMID 6251869.  编辑
  • Smith, H. T.; Ahmed, A. J.; Millett, F. Electrostatic interaction of cytochrome c with cytochrome c1 and cytochrome oxidase. The Journal of biological chemistry. 1981, 256 (10): 4984–90. PMID 6262312.  编辑
  • Geren, L. M.; Millett, F. Fluorescence energy transfer studies of the interaction between adrenodoxin and cytochrome c. The Journal of biological chemistry. 1981, 256 (20): 10485–9. PMID 6270113.  编辑
  • Favre, B; Zolnierowicz, S; Turowski, P; Hemmings, B. A. The catalytic subunit of protein phosphatase 2A is carboxyl-methylated in vivo. The Journal of biological chemistry. 1994, 269 (23): 16311–7. PMID 8206937.  编辑
  • Gao, B; Eisenberg, E; Greene, L. Effect of constitutive 70-k Da heat shock protein polymerization on its interaction with protein substrate. The Journal of biological chemistry. 1996, 271 (28): 16792–7. PMID 8663341.  编辑

其他圖像[编辑]

外部連結[编辑]

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