脂连蛋白

编辑

Adiponectin, C1Q and collagen domain containing
PDB rendering based on 1c28.
有效结构
4DOU
标识
代号	ADIPOQ; ACDC; ACRP30; ADIPQTL1; ADPN; APM-1; APM1; GBP28
扩展标识	遗传学：605441 鼠基因：106675 同源基因：3525
基因本体论描述 分子功能 · receptor binding · cytokine activity · hormone activity · protein binding · sialic acid binding · identical protein binding · protein homodimerization activity · eukaryotic cell surface binding 细胞成分 · extracellular region · collagen · extracellular space · endoplasmic reticulum 生物过程 · response to hypoxia · positive regulation of protein phosphorylation · glucose metabolic process · generation of precursor metabolites and energy · fatty acid beta-oxidation · response to nutrient · response to sucrose stimulus · response to glucose stimulus · positive regulation of signal transduction · negative regulation of platelet-derived growth factor receptor signaling pathway · positive regulation of protein kinase A signaling cascade · negative regulation of macrophage derived foam cell differentiation · negative regulation of tumor necrosis factor-mediated signaling pathway · positive regulation of cholesterol efflux · regulation of glucose metabolic process · negative regulation of smooth muscle cell migration · fatty acid oxidation · negative regulation of cell migration · negative regulation of granulocyte differentiation · negative regulation of protein autophosphorylation · positive regulation of cellular protein metabolic process · negative regulation of tumor necrosis factor production · positive regulation of interleukin-8 production · cellular response to insulin stimulus · positive regulation of myeloid cell apoptotic process · adiponectin-mediated signaling pathway · negative regulation of heterotypic cell-cell adhesion · low-density lipoprotein particle clearance · response to tumor necrosis factor · cellular response to drug · glucose homeostasis · positive regulation of I-kappaB kinase/NF-kappaB cascade · negative regulation of I-kappaB kinase/NF-kappaB cascade · negative regulation of MAP kinase activity · response to ethanol · negative regulation of fat cell differentiation · negative regulation of macrophage differentiation · negative regulation of low-density lipoprotein particle receptor biosynthetic process · negative regulation of gluconeogenesis · negative regulation of blood pressure · positive regulation of blood pressure · negative regulation of transcription, DNA-dependent · positive regulation of fatty acid metabolic process · positive regulation of glucose import · negative regulation of hormone secretion · negative regulation of smooth muscle cell proliferation · negative regulation of inflammatory response · positive regulation of peptidyl-tyrosine phosphorylation · negative regulation of phagocytosis · negative regulation of synaptic transmission · brown fat cell differentiation · protein homooligomerization · response to glucocorticoid stimulus · membrane depolarization · membrane hyperpolarization · protein heterotrimerization · negative regulation of ERK1 and ERK2 cascade · detection of oxidative stress · positive regulation of monocyte chemotactic protein-1 production · protein localization to plasma membrane · negative regulation of intracellular protein transport · negative regulation of DNA biosynthetic process · negative regulation of eukaryotic cell surface binding · positive regulation of glycogen (starch) synthase activity · positive regulation of metanephric glomerular visceral epithelial cell development · positive regulation of cAMP-dependent protein kinase activity · positive regulation of renal albumin absorption · negative regulation of platelet-derived growth factor receptor-alpha signaling pathway · negative regulation of metanephric mesenchymal cell migration
RNA表达模式
更多表达数据
直系同源体
物种	人类	鼠类
Entrez	9370	11450
Ensembl	ENSG00000181092	ENSMUSG00000022878
UniProt	Q15848	Q60994
参考序列	NM_001177800 (mRNA)	NM_009605 (mRNA)
	NP_001171271（蛋白）	NP_033735（蛋白）
基因位置	染色体3: 186.56 - 186.58 Mb	染色体16: 23.15 - 23.16 Mb
PubMed查询	[1]	[2]

脂连蛋白（英语：adiponectin，亦称为脂联素）是一种主要由脂肪细胞分泌的蛋白质激素，由ADIPOQ基因所编码，含244个氨基酸。成人体内的脂联素水平与脂肪储量负相关。