脂联素

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(重定向自脂连蛋白
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Adiponectin, C1Q and collagen domain containing

PDB rendering based on 1c28.
有效结构
PDB 直系同源检索:PDBe, RCSB
标识
代号 ADIPOQ; ACDC; ACRP30; ADIPQTL1; ADPN; APM-1; APM1; GBP28
扩展标识 遗传学605441 鼠基因106675 同源基因3525 GeneCards: ADIPOQ Gene
RNA表达模式
PBB GE ADIPOQ 207175 at tn.png
更多表达数据
直系同源体
物种 人类 小鼠
Entrez 9370 11450
Ensembl ENSG00000181092 ENSMUSG00000022878
UniProt Q15848 Q60994
mRNA序列 NM_001177800 NM_009605
蛋白序列 NP_001171271 NP_033735
基因位置 Chr 3:
186.56 – 186.58 Mb
Chr 16:
23.15 – 23.16 Mb
PubMed查询 [1] [2]

脂连蛋白英语adiponectin,亦称为脂联素)是一种主要由脂肪细胞分泌的蛋白质激素,由ADIPOQ基因所编码[1],含244个氨基酸。成人体内的脂联素水平与脂肪储量负相关[來源請求]

结构[编辑]

脂联素包含244个氨基酸,可分为4个结构域。从其N端起算,第一个是使其定位于细胞外的信号序列,第二个区域较短且在物种间高度变异,第三个65个氨基酸的区域与膠原蛋白相似,最后一个是脂联素的球状结构域。总的上看,这一蛋白与补体片段C1Q相似。 However, when the 3-dimensional structure of the globular region was determined, a striking similarity to TNFα was observed, despite unrelated protein sequences.[2]

受体[编辑]

脂联素可与几种受体结合,两种受体与G蛋白偶联受体同源性,一种属于钙粘蛋白家族[3][4]

These have distinct tissue specificities within the body and have different affinities to the various forms of adiponectin. The receptors affect the downstream target AMP kinase, an important cellular metabolic rate control point. Expression of the receptors is correlated with insulin levels, as well as reduced in mouse models of diabetes, particularly in skeletal muscle and adipose tissue.[5][6]

参考文献[编辑]

  1. ^ Maeda K, Okubo K, Shimomura I, Funahashi T, Matsuzawa Y, Matsubara K. cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose Most abundant Gene transcript 1). Biochem. Biophys. Res. Commun. April 1996, 221 (2): 286–9. doi:10.1006/bbrc.1996.0587. PMID 8619847. 
  2. ^ Shapiro L, Scherer PE. The crystal structure of a complement-1q family protein suggests an evolutionary link to tumor necrosis factor. Curr. Biol. March 1998, 8 (6): 335–8. doi:10.1016/S0960-9822(98)70133-2. PMID 9512423. 
  3. ^ Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S et al. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature. 2003, 423 (6941): 762–9. doi:10.1038/nature01705. PMID 12802337. 
  4. ^ Hug C, Wang J, Ahmad NS, Bogan JS, Tsao TS, Lodish HF. T-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/adiponectin. Proc. Natl. Acad. Sci. U.S.A. 2004, 101 (28): 10308–13. doi:10.1073/pnas.0403382101. PMC 478568. PMID 15210937. 
  5. ^ Fang X, Sweeney G. Mechanisms regulating energy metabolism by adiponectin in obesity and diabetes. Biochem. Soc. Trans. 2006, 34 (Pt 5): 798–801. doi:10.1042/BST0340798. PMID 17052201. 
  6. ^ Bonnard C, Durand A, Vidal H, Rieusset J. Changes in adiponectin, its receptors and AMPK activity in tissues of diet-induced diabetic mice. Diabetes Metab. 2008, 34 (1): 52–61. doi:10.1016/j.diabet.2007.09.006. PMID 18222103. 

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