脂连蛋白

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Adiponectin, C1Q and collagen domain containing

PDB rendering based on 1c28.
有效结构
PDB 直系同源检索:PDBe, RCSB
标识
代号 ADIPOQ; ACDC; ACRP30; ADIPQTL1; ADPN; APM-1; APM1; GBP28
扩展标识 遗传学605441 鼠基因106675 同源基因3525 GeneCards: ADIPOQ Gene
RNA表达模式
PBB GE ADIPOQ 207175 at tn.png
更多表达数据
直系同源体
物种 人类 鼠类
Entrez 9370 11450
Ensembl ENSG00000181092 ENSMUSG00000022878
UniProt Q15848 Q60994
mRNA序列 NM_001177800 NM_009605
蛋白序列 NP_001171271 NP_033735
基因位置 Chr 3:
186.56 – 186.58 Mb
Chr 16:
23.15 – 23.16 Mb
PubMed查询 [1] [2]

脂连蛋白英语adiponectin,亦称为脂联素)是一种主要由脂肪细胞分泌的蛋白质激素,由ADIPOQ基因所编码[1],含244个氨基酸。成人体内的脂联素水平与脂肪储量负相关[來源請求]

结构[编辑]

脂联素包含244个氨基酸,可分为4个结构域。从N端其算,第一个是使其定位于细胞外的信号序列, next is a short region that varies between species; the third is a 65-amino acid region with similarity to collagenous proteins; the last is a globular domain. Overall this gene shows similarity to the complement 1Q factors (C1Q). However, when the 3-dimensional structure of the globular region was determined, a striking similarity to TNFα was observed, despite unrelated protein sequences.[2]

参考文献[编辑]

  1. ^ Maeda K, Okubo K, Shimomura I, Funahashi T, Matsuzawa Y, Matsubara K. cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose Most abundant Gene transcript 1). Biochem. Biophys. Res. Commun. April 1996, 221 (2): 286–9. doi:10.1006/bbrc.1996.0587. PMID 8619847. 
  2. ^ Shapiro L, Scherer PE. The crystal structure of a complement-1q family protein suggests an evolutionary link to tumor necrosis factor. Curr. Biol. March 1998, 8 (6): 335–8. doi:10.1016/S0960-9822(98)70133-2. PMID 9512423. 

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