苹果酸脱氢酶 (草酰乙酸脱羧) (NADP⁺)

苹果酸脱氢酶 (草酰乙酸脱羧) (NADP+)
	苹果酸脱氢酶 (草酰乙酸脱羧) (NADP+)的结构（PDB 2AW5）
命名
系统命名	(S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)
缩写
别名	'malic' enzyme; pyruvic-malic carboxylase; malate dehydrogenase (decarboxylating, NADP); NADP-linked decarboxylating malic enzyme; NADP-malic enzyme; NADP-specific malic enzyme; NADP-specific malate dehydrogenase; malate dehydrogenase (NADP, decarboxylating); L-malate:NADP oxidoreductase; malate dehydrogenase (oxaloacetate-decarboxylating) (NADP)
识别码
EC编号	1.1.1.40
CAS号	9028-47-1
数据库
IntEnz	IntEnz浏览
BRENDA	BRENDA入口
ExPASy	NiceZyme浏览
KEGG	KEGG入口
MetaCyc	代谢路径
PRIAM	概述
PDB	RCSB PDB PDBe PDBsum
基因本体	AmiGO / EGO
搜索
PMC	相关文献
PubMed	相关文献

苹果酸脱氢酶 (草酰乙酸脱羧) (NADP⁺)（英语：malate dehydrogenase (oxaloacetate-decarboxylating) (NADP⁺)，EC 1.1.1.40）是一种以NAD⁺或NADP⁺为受体、作用于供体 CH-OH 基团上的氧化还原酶。这种酶能催化以下酶促反应：

(S)-苹果酸 + NADP⁺ $\rightleftharpoons$ 丙酮酸 + CO₂ + NADPH

苹果酸脱氢酶 (草酰乙酸脱羧) (NADP⁺)是C₄和CAM 植物固定二氧化碳过程中使用的三种脱羧酶之一（其余两种分别为苹果酸脱氢酶 (脱羧)和磷酸烯醇丙酮酸羧化激酶）。^[1]^[2]

参考文献 [编辑]

^ Kanai R, Edwards, GE. 3. The Biochemistry of C4 Photosynthesis//In Sage RF, Monson RK. C4 PlantBiology. 1999: 43–87. ISBN 0126144400.
^ Christopher JT, Holtum JAM. Patterns of carbon partitioning in leaves of Crassulacean acid metabolism species during deacidification. Plant Physiol. 1996, 112 (1): 393–399. PMC 157961. PMID 12226397.

Harary, I., Korey, S.R. and Ochoa, S. Biosynthesis of dicarboxylic acids by carbon dioxide fixation. VII Equilibrium of malic enzyme reaction. J. Biol. Chem. 1953, 203 (2): 595–604. PMID 13084629.
Ochoa S, Mehler AH and Kornberg A. Biosynthesis of dicarboxylic acids by carbon dioxide fixation. I Isolation and properties of an enzyme from pigeon liver catalyzing the reversible oxidative decarboxylation of l-malic acid. J. Biol. Chem. 1948, 174: 979–1000.
RUTTER WJ, LARDY HA. Purification and properties of pigeon liver malic enzyme. J. Biol. Chem. 1958, 233 (2): 374–82. PMID 13563505.
Strickland RG. Some properties of the malic enzyme of pigeon liver. 1. Conversion of malate into pyruvate. Biochem. J. 1959, 73: 646–654.
Strickland RG. Some properties of the malic enzyme of pigeon liver. 2. Synthesis of malate from pyruvate. Biochem. J. 1959, 73: 654–659. PMC 1197116. PMID 13834657.
Walker DA. Physiological studies on acid metabolism. 7. Malic enzyme from Kalanchoe crenata: effects of carbon dioxide concentration. Biochem. J. 1960, 74: 216–223. PMC 1204145. PMID 13842495.