钙调磷酸酶

编辑

蛋白磷酸酶3，催化亚基，α同工酶
PDB rendering based on 1aui.
有效结构
1AUI, 1M63, 1MF8, 2JOG, 2JZI, 2P6B, 2R28, 2W73
标识
代号	PPP3CA; CALN; CALNA; CALNA1; CCN1; CNA1; PPP2B
扩展标识	遗传学：114105 鼠基因：107164 同源基因：55497
酶分类号	3.1.3.16
基因本体论描述 分子功能 · protein serine/threonine phosphatase activity · calcium-dependent protein serine/threonine phosphatase activity · calcium ion binding · protein binding · calmodulin binding · hydrolase activity · protein heterodimerization activity 细胞成分 · soluble fraction · insoluble fraction · nucleus · nucleolus · cytoplasm · mitochondrion · microsome · cytosol · cytosol · calcineurin complex · membrane · Z disc 生物过程 · G1/S transition of mitotic cell cycle · response to amphetamine · protein dephosphorylation · protein import into nucleus · calcium ion transport · response to stress · positive regulation of transcription from RNA polymerase II promoter · negative regulation of insulin secretion · skeletal muscle fiber development · regulation of synaptic transmission · regulation of excitatory postsynaptic membrane potential · cellular response to glucose stimulus
RNA表达模式
更多表达数据
直系同源体
物种	人类	鼠类
Entrez	5530	19055
Ensembl	ENSG00000138814	ENSMUSG00000028161
UniProt	Q08209	P63328
参考序列	NM_000944.4 (mRNA)	NM_008913.4 (mRNA)
	NP_000935.1（蛋白）	NP_032939.1（蛋白）
基因位置	染色体4: 101.94 - 102.27 Mb	染色体3: 136.33 - 136.6 Mb
PubMed查询	[2]	[3]

钙调磷酸酶（英语：Calcineurin，亦称为蛋白磷酸酶3或蛋白磷酸酶2B，分别简称为PPP3CA与PP2B）其在体内的作用为启动T细胞并可以通过药物来阻断这一过程。

钙调磷酸酶为很多种免疫抑制药的作用对象如，环孢霉素,吡美莫司和他克莫司。

深入阅读

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• Wang MG, Yi H, Guerini D, et al.. Calcineurin A alpha (PPP3CA), calcineurin A beta (PPP3CB) and calcineurin B (PPP3R1) are located on human chromosomes 4, 10q21→q22 and 2p16→p15 respectively. Cytogenet. Cell Genet. 1997, 72 (2-3): 236–41. doi:10.1159/000134198. PMID 8978785. 
• Shibasaki F, Kondo E, Akagi T, McKeon F. Suppression of signalling through transcription factor NF-AT by interactions between calcineurin and Bcl-2. Nature. 1997, 386 (6626): 728–31. doi:10.1038/386728a0. PMID 9109491. 
• Kashishian A, Howard M, Loh C, et al.. AKAP79 inhibits calcineurin through a site distinct from the immunophilin-binding region. J. Biol. Chem. 1998, 273 (42): 27412–9. doi:10.1074/jbc.273.42.27412. PMID 9765270. 
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• Fuentes JJ, Genescà L, Kingsbury TJ, et al.. DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways. Hum. Mol. Genet. 2000, 9 (11): 1681–90. doi:10.1093/hmg/9.11.1681. PMID 10861295. 
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外部链接

• MeSH（醫學主題詞）上面的Calcineurin
• eMedicine Dictionary上的Calcineurin