降鈣素

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Calcitonin/calcitonin-related polypeptide, alpha

NMR solution structure of salmon calcitonin in SDS micelles.[1]
有效结构
PDB 直系同源检索:PDBe, RCSB
标识
代号 CALCA; CALC1; CGRP; CGRP-I; CGRP1; CT; KC; MGC126648
扩展标识 遗传学114130 鼠基因2151253 同源基因1319 GeneCards: CALCA Gene
RNA表达模式
PBB GE CALCA 210728 s at tn.png
PBB GE CALCA 210727 at tn.png
PBB GE CALCA 217495 x at tn.png
更多表达数据
直系同源体
物种 人类 鼠类
Entrez 796 12310
Ensembl ENSG00000110680 ENSMUSG00000030669
UniProt P01258 Q99JA0
mRNA序列 NM_001033952 NM_001033954
蛋白序列 NP_001029124 NP_001029126
基因位置 Chr 11:
14.94 – 14.95 Mb
Chr 7:
114.42 – 114.43 Mb
PubMed查询 [1] [2]

降鈣素英语Calcitonin,又譯为抑鈣激素)是一種含有32個胺基酸的直線型多肽激素,在人體裡是由甲狀腺濾泡旁細胞(parafollicular cells,又稱C細胞)製造。在魚類爬蟲類鳥類哺乳類身上都有發現這種激素。主要功能是降低血鈣。但降鈣素通常對於調節人體血液中鈣離子(Ca2+)的恆定並沒有很顯著的重要性。[2]

主要作用[编辑]

降鈣素影響了鈣離子和磷酸鹽的代謝過程,其功能多半是拮抗副甲狀腺素的作用。[3]

降鈣素主要透過下列四種方式降低血鈣濃度:

  1. 抑制小腸對於鈣離子的吸收。[4]
  2. 抑制蝕骨細胞(Osteoclast),減少骨骼中的鈣離子流失到血液中[5]
  3. 抑制腎小管對磷酸根的再吸收作用。[6]
  4. 抑制腎小管對鈣離子的再吸收作用,增加鈣離子自尿液流失。[6]

分泌[编辑]

刺激降鈣素分泌的因素:

  • 血漿中鈣離子濃度過高[7]


參考資料[编辑]

  1. ^ PDB 2glhAndreotti G, Méndez BL, Amodeo P, Morelli MA, Nakamuta H, Motta A. Structural determinants of salmon calcitonin bioactivity: the role of the Leu-based amphipathic alpha-helix. J. Biol. Chem. 2006.August, 281 (34): 24193–203. doi:10.1074/jbc.M603528200. PMID 16766525. 
  2. ^ Costoff A. Sect. 5, Ch. 6: Biological Actions of CT. Medical College of Georgia. [2008-08-07]. 
  3. ^ Boron WF, Boulpaep EL. Endocrine system chapter//Medical Physiology: A Cellular And Molecular Approach. Elsevier/Saunders. 2004. ISBN 1-4160-2328-3. 
  4. ^ Costoff A. Sect. 5, Ch. 6: Effects of CT on the Small Intestine. Medical College of Georgia. [2008-08-07]. 
  5. ^ Costoff A. Sect. 5, Ch. 6: Effects of CT on Bone. Medical College of Georgia. [2008-08-07]. 
  6. ^ 6.0 6.1 Carney SL. Calcitonin and human renal calcium and electrolyte transport. Miner Electrolyte Metab. 1997, 23 (1): 43–7. PMID 9058369. 
  7. ^ Costanzo, Linda S. BRS Physiology. Lippincott, Williams, & Wilkins. 2007: 263. ISBN 978-0781773119. 
  8. ^ Erdogan MF, Gursoy A, Kulaksizoglu M. Long-term effects of elevated gastrin levels on calcitonin secretion. J Endocrinol Invest. 2006.October, 29 (9): 771–775. PMID 17114906.