黄体生成素/绒毛膜促性腺激素受体

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Luteinizing hormone/choriogonadotropin receptor
黄体生成素/绒毛膜促性腺激素受体
有效结构
PDB 直系同源检索:PDBe, RCSB
标识
代号 LHCGR; HHG; LCGR; LGR2; LH/CG-R; LH/CGR; LHR; LHRHR; LSH-R; ULG5
扩展标识 遗传学152790 鼠基因96783 同源基因37276 IUPHAR:  LH ChEMBL: 1854 GeneCards: LHCGR Gene
RNA表达模式
PBB GE LHCGR 207240 s at tn.png
更多表达数据
直系同源体
物种 人类 鼠类
Entrez 3973 16867
Ensembl ENSG00000138039 ENSMUSG00000024107
UniProt P22888 P30730
mRNA序列 NM_000233 NM_013582
蛋白序列 NP_000224 NP_038610
基因位置 Chr 2:
48.86 – 48.98 Mb
Chr 17:
88.74 – 88.79 Mb
PubMed查询 [1] [2]

黄体生成素/绒毛膜促性腺激素受体英语luteinizing hormone/choriogonadotropin receptor,缩写LHCGR也作 lutropin/choriogonadotropin receptorLCGRluteinizing hormone receptorLHR )是一种主要出现在卵巢睾丸跨膜受体,但在一些性腺外的器官如子宫乳房也有表达。该受体是G蛋白偶联受体(GPCR)的一种,既能与黄体生成素(LH)互作也能与绒毛膜促性腺激素(如人类的hCG),其激活是在繁殖期间的荷尔蒙运作所需的。

LHCGR基因[编辑]

LHCGR位于人类基因组上的2號染色體p21区,接近类似的促卵泡激素受体(FSHR)基因,长约70Kbp(FSHR为54Kpb)[1],除了与FSHR相似外,还类似于促甲状腺激素受体(TSHR)。

历史[编辑]

馬丁·羅德貝爾艾爾佛列·古曼·吉爾曼因发现G蛋白系统而获得1994年的诺贝尔生理学或医学奖

相互作用[编辑]

黄体生成素/绒毛膜促性腺激素受体与GIPC1能进行相互作用[2]

参考文献[编辑]

  1. ^ Simoni M, Gromoll J, Nieschlag E. The follicle-stimulating hormone receptor: biochemistry, molecular biology, physiology, and pathophysiology. Endocr. Rev. 1997, 18 (6): 739–73. doi:10.1210/er.18.6.739. PMID 9408742. 
  2. ^ Hirakawa, Takashi; Galet Colette, Kishi Mikiko, Ascoli Mario. GIPC binds to the human lutropin receptor (hLHR) through an unusual PDZ domain binding motif, and it regulates the sorting of the internalized human choriogonadotropin and the density of cell surface hLHR. J. Biol. Chem. (United States). Dec 2003, 278 (49): 49348–57. doi:10.1074/jbc.M306557200. ISSN 0021-9258. PMID 14507927. 

延伸阅读[编辑]

  • Ji TH, Ryu KS, Gilchrist R, Ji I. Interaction, signal generation, signal divergence, and signal transduction of LH/CG and the receptor.. Recent Prog. Horm. Res. 1997, 52: 431–53; discussion 454. PMID 9238862. 
  • Dufau ML. The luteinizing hormone receptor.. Annu. Rev. Physiol. 1998, 60: 461–96. doi:10.1146/annurev.physiol.60.1.461. PMID 9558473. 
  • Ascoli M, Fanelli F, Segaloff DL. The lutropin/choriogonadotropin receptor, a 2002 perspective.. Endocr. Rev. 2002, 23 (2): 141–74. doi:10.1210/er.23.2.141. PMID 11943741. 
  • Amsterdam A, Hanoch T, Dantes A et al. Mechanisms of gonadotropin desensitization. Mol. Cell. Endocrinol. 2003, 187 (1–2): 69–74. doi:10.1016/S0303-7207(01)00701-8. PMID 11988313. 
  • Fanelli F, Puett D. Structural aspects of luteinizing hormone receptor: information from molecular modeling and mutagenesis. Endocrine. 2003, 18 (3): 285–93. doi:10.1385/ENDO:18:3:285. PMID 12450321. 
  • Latronico AC, Segaloff DL. Insights Learned from L457(3.43)R, an Activating Mutant of the Human Lutropin Receptor. Mol. Cell. Endocrinol. 2007,. 260-262: 287–93. doi:10.1016/j.mce.2005.11.053. PMC 1785107. PMID 17055147. 
  • Nagayama Y, Russo D, Wadsworth HL et al. Eleven amino acids (Lys-201 to Lys-211) and 9 amino acids (Gly-222 to Leu-230) in the human thyrotropin receptor are involved in ligand binding. J. Biol. Chem. 1991, 266 (23): 14926–30. PMID 1651314. 
  • Jia XC, Oikawa M, Bo M et al. Expression of human luteinizing hormone (LH) receptor: interaction with LH and chorionic gonadotropin from human but not equine, rat, and ovine species. Mol. Endocrinol. 1991, 5 (6): 759–68. doi:10.1210/mend-5-6-759. PMID 1922095. 
  • Minegishi T, Nakamura K, Takakura Y et al. Cloning and sequencing of human LH/hCG receptor cDNA. Biochem. Biophys. Res. Commun. 1990, 172 (3): 1049–54. doi:10.1016/0006-291X(90)91552-4. PMID 2244890. 
  • Rousseau-Merck MF, Misrahi M, Atger M et al. Localization of the human luteinizing hormone/choriogonadotropin receptor gene (LHCGR) to chromosome 2p21. Cytogenet. Cell Genet. 1991, 54 (1–2): 77–9. doi:10.1159/000132962. PMID 2249480. 
  • Xie YB, Wang H, Segaloff DL. Extracellular domain of lutropin/choriogonadotropin receptor expressed in transfected cells binds choriogonadotropin with high affinity. J. Biol. Chem. 1991, 265 (35): 21411–4. PMID 2254302. 
  • Frazier AL, Robbins LS, Stork PJ et al. Isolation of TSH and LH/CG receptor cDNAs from human thyroid: regulation by tissue specific splicing. Mol. Endocrinol. 1991, 4 (8): 1264–76. doi:10.1210/mend-4-8-1264. PMID 2293030. 
  • Keutmann HT, Charlesworth MC, Mason KA et al. A receptor-binding region in human choriogonadotropin/lutropin beta subunit. Proc. Natl. Acad. Sci. U.S.A. 1987, 84 (7): 2038–42. doi:10.1073/pnas.84.7.2038. PMC 304579. PMID 3470775. 
  • Jiang X, Dreano M, Buckler DR, et al.. Structural predictions for the ligand-binding region of glycoprotein hormone receptors and the nature of hormone-receptor interactions. Structure. 1996, 3 (12): 1341–53. doi:10.1016/S0969-2126(01)00272-6. PMID 8747461. 
  • Atger M, Misrahi M, Sar S et al. Structure of the human luteinizing hormone-choriogonadotropin receptor gene: unusual promoter and 5' non-coding regions. Mol. Cell. Endocrinol. 1995, 111 (2): 113–23. doi:10.1016/0303-7207(95)03557-N. PMID 7556872. 
  • Latronico AC, Anasti J, Arnhold IJ et al. A novel mutation of the luteinizing hormone receptor gene causing male gonadotropin-independent precocious puberty. J. Clin. Endocrinol. Metab. 1995, 80 (8): 2490–4. doi:10.1210/jc.80.8.2490. PMID 7629248. 
  • Shenker A, Laue L, Kosugi S et al. A constitutively activating mutation of the luteinizing hormone receptor in familial male precocious puberty. Nature. 1993, 365 (6447): 652–4. doi:10.1038/365652a0. PMID 7692306. 
  • Yano K, Saji M, Hidaka A et al. A new constitutively activating point mutation in the luteinizing hormone/choriogonadotropin receptor gene in cases of male-limited precocious puberty. J. Clin. Endocrinol. Metab. 1995, 80 (4): 1162–8. doi:10.1210/jc.80.4.1162. PMID 7714085. 
  • Kremer H, Kraaij R, Toledo SP et al. Male pseudohermaphroditism due to a homozygous missense mutation of the luteinizing hormone receptor gene. Nat. Genet. 1995, 9 (2): 160–4. doi:10.1038/ng0295-160. PMID 7719343. 
  • Kosugi S, Van Dop C, Geffner ME et al. Characterization of heterogeneous mutations causing constitutive activation of the luteinizing hormone receptor in familial male precocious puberty. Hum. Mol. Genet. 1995, 4 (2): 183–8. doi:10.1093/hmg/4.2.183. PMID 7757065. 
  • Kremer H, Mariman E, Otten BJ et al. Cosegregation of missense mutations of the luteinizing hormone receptor gene with familial male-limited precocious puberty. Hum. Mol. Genet. 1994, 2 (11): 1779–83. doi:10.1093/hmg/2.11.1779. PMID 8281137. 

外部链接[编辑]