黄嘌呤

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黄嘌呤
IUPAC名
3,7-Dihydro-purine-2,6-dione
别名 1H-Purine-2,6-diol
识别
CAS号 69-89-6
PubChem 1188
SMILES
性质
化学式 C5H4N4O2
摩尔质量 152.111 g·mol⁻¹
外观 白色固体
熔点 (加热分解)
溶解性 1 g/ 14.5 L @ 16 °C
1 g/1.4 L @ 100 °C
若非注明,所有数据均出自一般条件(25 ℃,100 kPa)下。

黄嘌呤」(英语xanthine)是一種廣泛分佈於人體及其他生物體的器官及體液內的一種嘌呤,常用作温和的兴奋剂和支气管扩张剂,特别用于治疗哮喘症状。咖啡因茶碱可可碱(主要在巧克力中发现)等常見的溫和興奮劑均由黄嘌呤衍生出來。[1] [2] [3][4]

黄嘌呤也是嘌呤代謝後的产物,并会在黄嘌呤氧化酶的作用下转换为尿酸

黄嘌呤是嘌呤衍生物,并且很少在核酸的成分中发现。

參見[编辑]

參考文獻[编辑]

  1. ^ Spiller, Gene A. (1998). Caffeine. Boca Raton: CRC Press. ISBN 0-8493-2647-8 .
  2. ^ Daly JW, Padgett WL, Shamim MT (July 1986). "Analogues of caffeine and theophylline: effect of structural alterations on affinity at adenosine receptors". Journal of Medicinal Chemistry 29 (7): 1305–8. Daly, J. W.; Padgett, W. L.; Shamim, M. T. Analogs of caffeine and theophylline: Effect of structural alterations on affinity at adenosine receptors. Journal of Medicinal Chemistry. 1986年, 29 (7): 1305–1308. doi:10.1021/jm00157a035. PMID 3806581.  编辑. PMID 3806581
  3. ^ Choi OH, Shamim MT, Padgett WL, Daly JW (1988). "Caffeine and theophylline analogues: correlation of behavioral effects with activity as adenosine receptor antagonists and as phosphodiesterase inhibitors". Life Sciences 43 (5): 387–98. Choi, O. H.; Shamim, M. T.; Padgett, W. L.; Daly, J. W. Caffeine and theophylline analogues: Correlation of behavioral effects with activity as adenosine receptor antagonists and as phosphodiesterase inhibitors. Life Sciences. 1988年, 43 (5): 387–398. doi:10.1016/0024-3205(88)90517-6. PMID 2456442.  编辑. PMID 2456442
  4. ^ Deree J, Martins JO, Melbostad H, Loomis WH, Coimbra R. Insights into the regulation of TNF-alpha production in human mononuclear cells: the effects of non-specific phosphodiesterase inhibition. Clinics (São Paulo). 2008年, 63 (3): 321–8. doi:10.1590/S1807-59322008000300006. PMC 2664230. PMID 18568240.