CXCL10

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Chemokine (C-X-C motif) ligand 10

PDB rendering based on 1o7z.
有效结构
PDB 直系同源检索:PDBe, RCSB
标识
代号 CXCL10; C7; IFI10; INP10; IP-10; SCYB10; crg-2; gIP-10; mob-1
扩展标识 遗传学147310 鼠基因1352450 同源基因1203 GeneCards: CXCL10 Gene
RNA表达模式
PBB GE CXCL10 204533 at tn.png
更多表达数据
直系同源体
物种 人类 鼠类
Entrez 3627 15945
Ensembl ENSG00000169245 ENSMUSG00000034855
UniProt P02778 P17515
mRNA序列 NM_001565 NM_021274
蛋白序列 NP_001556 NP_067249
基因位置 Chr 4:
76.94 – 76.94 Mb
Chr 5:
92.35 – 92.35 Mb
PubMed查询 [1] [2]

CXCL10英语C-X-C motif chemokine 10)是一小分子的细胞因子属于CXC趋化因子家族[1],又被称作“干扰素伽玛诱导的10千道尔顿蛋白”(10 kDa interferon-gamma-induced protein,IP-10)[2]干扰素伽玛可以在多种细胞(如巨噬细胞[3]单核细胞[3]内皮细胞[4]成纤维细胞)中诱导CXCL10的表达。CXCL10的功能包括对T细胞和单核细胞的细胞趋化作用[5][6],促进T细胞黏附于内皮细胞[4],抗肿瘤[7],及新血管形成[4]。人类的CXCL10基因与CXCL9CXCL11的基因相邻聚集在第四染色体上。CXCL10, CXCL9和CXCL11结合趋化因子受体CXCR3而起其细胞趋化作用[5][6]

参见[编辑]

参考文献[编辑]

  1. ^ Liu L, Callahan MK, Huang D, Ransohoff RM. Chemokine receptor CXCR3: an unexpected enigma. Curr Top Dev Biol. 2005;68:149-81.
  2. ^ Kaplan G, Luster AD, Hancock G, Cohn ZA. The expression of a gamma interferon-induced protein (IP-10) in delayed immune responses in human skin. J Exp Med. 1987 Oct 1;166(4):1098-108.
  3. ^ 3.0 3.1 Narumi S, Hamilton TA. Inducible expression of murine IP-10 mRNA varies with the state of macrophage inflammatory activity. J Immunol. 1991 May 1;146(9):3038-44.
  4. ^ 4.0 4.1 4.2 Angiolillo AL, Sgadari C, Taub DD, Liao F, Farber JM, Maheshwari S, Kleinman HK, Reaman GH, Tosato G. Human interferon-inducible protein 10 is a potent inhibitor of angiogenesis in vivo. J Exp Med. 1995 Jul 1;182(1):155-62.
  5. ^ 5.0 5.1 Loetscher M, Gerber B, Loetscher P, Jones SA, Piali L, Clark-Lewis I, Baggiolini M, Moser B. Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes. J Exp Med. 1996 Sep 1;184(3):963-9.
  6. ^ 6.0 6.1 Weng Y, Siciliano SJ, Waldburger KE, Sirotina-Meisher A, Staruch MJ, Daugherty BL, Gould SL, Springer MS, DeMartino JA. Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors. J Biol Chem. 1998 Jul 17;273(29):18288-91.
  7. ^ Luster AD, Leder P. IP-10, a -C-X-C- chemokine, elicits a potent thymus-dependent antitumor response in vivo. J Exp Med. 1993 Sep 1;178(3):1057-65

外部链接[编辑]