Meyers合成

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Meyers合成(Meyers synthesis),以美国化学家 Albert I. Meyers 的名字命名。

通过噁嗪水解制取不对称类。[1][2][3][4]


Meyers合成


2-取代的二氢-1,3-噁嗪的α-氢被强碱(如丁基锂)夺取,生成的碳负离子被卤代烃烷化,然后硼氢化钠将碳氮双键还原,最后在草酸水溶液中水解,半缩胺转变为醛。

参见[编辑]

参考资料[编辑]

  1. ^ Aldehydes from dihydro-1,3-oxazines. I. Synthesis of aliphatic aldehydes and their C-1 deuterated derivatives Albert I. Meyers, Aiko Nabeya, H. Wayne Adickes, Ieva R. Politzer J. Am. Chem. Soc. 1969; 91(3); 763-764. doi:10.1021/ja01031a053
  2. ^ Aldehydes from dihydro-1,3-oxazines. II. Synthesis of .alpha.,.beta.-unsaturated aldehydes and their C-1 deuterated derivatives Albert I. Meyers, Aiko Nabeya, H. Wayne Adickes, J. Michael Fitzpatrick, G. Ray Malone, and Ieva R. Politzer pp 764 - 765; J. Am. Chem. Soc. 1969 {{DOI:10.1021/ja01031a054}}
  3. ^ Aldehydes from dihydro-1,3-oxazines. III. Synthesis of cycloalkanecarboxaldehydes Albert I. Meyers, H. Wayne Adickes, Ieva R. Politzer, and Warren N. Beverung pp 765 - 767; J. Am. Chem. Soc. 1969 doi:10.1021/ja01031a055
  4. ^ Organic Syntheses, Coll. Vol. 6, p.905 (1988); Vol. 51, p.24 (1971). http://www.orgsynth.org/orgsyn/pdfs/CV6P0905.pdf