SIN3B

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SIN3转录调节同源物B(酵母)
SIN3 transcription regulator homolog B (yeast)

PDB rendering based on 1e91.
有效结构
PDB 直系同源检索:PDBe, RCSB
标识
代号 SIN3B; KIAA0700
扩展标识 遗传学607777 鼠基因107158 同源基因81810 GeneCards: SIN3B Gene
RNA表达模式
PBB GE SIN3B 209352 s at tn.png
PBB GE SIN3B 39705 at tn.png
更多表达数据
直系同源体
物种 人类 鼠类
Entrez 23309 20467
Ensembl ENSG00000127511 ENSMUSG00000031622
UniProt O75182 Q62141
mRNA序列 NM_015260 NM_001113248
蛋白序列 NP_056075 NP_001106719
基因位置 Chr 19:
16.94 – 16.99 Mb
Chr 8:
72.72 – 72.76 Mb
PubMed查询 [1] [2]

成对两亲性螺旋蛋白SIN3B英语Paired amphipathic helix protein Sin3b)是一个由人类基因SIN3B编码的蛋白质[1][2]


互作[编辑]

SIN3B与HDAC1[3][4]Zinc finger and BTB domain-containing protein 16[5]SUDS3[6]以及IKZF1[4][7]等蛋白有相互作用

另见[编辑]

参考文献[编辑]

  1. ^ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. DNA Res. 1998.December, 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811. 
  2. ^ Entrez Gene: SIN3B SIN3 homolog B, transcription regulator (yeast). 
  3. ^ Zhang, Y; Ng H H, Erdjument-Bromage H, Tempst P, Bird A, Reinberg D. Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation. Genes Dev. (UNITED STATES). 1999.August, 13 (15): 1924–35. doi:10.1101/gad.13.15.1924. ISSN 0890-9369. PMC 316920. PMID 10444591. 
  4. ^ 4.0 4.1 Koipally, J; Renold A, Kim J, Georgopoulos K. Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes. EMBO J. (ENGLAND). 1999.June, 18 (11): 3090–100. doi:10.1093/emboj/18.11.3090. ISSN 0261-4189. PMC 1171390. PMID 10357820. 
  5. ^ David, G; Alland L, Hong S H, Wong C W, DePinho R A, Dejean A. Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein. Oncogene (ENGLAND). 1998.May, 16 (19): 2549–56. doi:10.1038/sj.onc.1202043. ISSN 0950-9232. PMID 9627120. 
  6. ^ Alland, Leila; David Gregory, Shen-Li Hong, Potes Jason, Muhle Rebecca, Lee Hye-Chun, Hou Harry, Chen Ken, DePinho Ronald A. Identification of Mammalian Sds3 as an Integral Component of the Sin3/Histone Deacetylase Corepressor Complex. Mol. Cell. Biol. (United States). 2002.April, 22 (8): 2743–50. doi:10.1128/MCB.22.8.2743-2750.2002. ISSN 0270-7306. PMC 133736. PMID 11909966. 
  7. ^ Koipally, Joseph; Georgopoulos Katia. A molecular dissection of the repression circuitry of Ikaros. J. Biol. Chem. (United States). 2002.August, 277 (31): 27697–705. doi:10.1074/jbc.M201694200. ISSN 0021-9258. PMID 12015313. 

延伸阅读[编辑]

外部链接[编辑]

SIN3B引用了美国国家医学图书馆提供的資料,这些資料属于公共领域