UBTF

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Upstream binding transcription factor, RNA polymerase I
RNA聚合酶I上游结合因子

PDB rendering based on 1k99.
有效结构
PDB 直系同源检索:PDBe, RCSB
标识
代号 UBTF; NOR-90; UBF; UBF-1; UBF1
扩展标识 遗传学600673 鼠基因98512 同源基因7970 GeneCards: UBTF Gene
RNA表达模式
PBB GE UBTF 202692 s at tn.png
PBB GE UBTF 214881 s at tn.png
更多表达数据
直系同源体
物种 人类 鼠类
Entrez 7343 21429
Ensembl ENSG00000108312 ENSMUSG00000020923
UniProt P17480 A2AWT5
mRNA序列 NM_001076683 NM_001044383
蛋白序列 NP_001070151 NP_001037848
基因位置 Chr 17:
42.28 – 42.3 Mb
Chr 11:
102.3 – 102.32 Mb
PubMed查询 [1] [2]

核仁转录因子1(Nucleolar transcription factor 1)又叫上游结合转录因子(Upstream binding transcription factor,缩写UBTF)或上游结合因子1(Upstream binding factor 1,缩写UBF1)是一种由人类基因UBTF 所编码的蛋白质[1][2]

UBTF是18S、5.8S和28S的核糖体RNA的转录所必须的转录因子,和SL1因子(一个四聚体,包括一个TBP,即TATA结合蛋白英语TATA-binding protein和3个转录辅助因子TAF1英语TAF1)共同起作用。在人体中存在94和97kD的两种UBF多肽链。UBF是一种核仁磷酸化蛋白(nucleolar phosphoprotein),同时具有DNA结合结构域和反式激活结构域。 Sequence-specific DNA binding to the core and upstream control elements of the human rRNA promoter is mediated through several HMG boxes[2]


相互作用[编辑]

UBTF已知能与酪蛋白激酶2α亚基英语Casein kinase 2, alpha 1[3]TAF1C[4][5]视网膜母细胞瘤蛋白[6]TAF1[7]进行交互作用

参考文献[编辑]

  1. ^ Matera AG, Wu W, Imai H, O'Keefe CL, Chan EK. Molecular cloning of the RNA polymerase I transcription factor hUBF/NOR-90 (UBTF) gene and localization to 17q21.3 by fluorescence in situ hybridization and radiation hybrid mapping. Genomics. May 1997, 41 (1): 135–8. doi:10.1006/geno.1997.4647. PMID 9126496. 
  2. ^ 2.0 2.1 Entrez Gene: UBTF upstream binding transcription factor, RNA polymerase I. 
  3. ^ Voit, R; Kuhn A, Sander E E, Grummt I. Activation of mammalian ribosomal gene transcription requires phosphorylation of the nucleolar transcription factor UBF. Nucleic Acids Res. (ENGLAND). July 1995, 23 (14): 2593–9. doi:10.1093/nar/23.14.2593. ISSN 0305-1048. PMC 307079. PMID 7651819. 
  4. ^ Voit, R; Grummt I. Phosphorylation of UBF at serine 388 is required for interaction with RNA polymerase I and activation of rDNA transcription. Proc. Natl. Acad. Sci. U.S.A. (United States). November 2001, 98 (24): 13631–6. doi:10.1073/pnas.231071698. ISSN 0027-8424. PMC 61092. PMID 11698641. 
  5. ^ Zhai, W; Comai L. Repression of RNA Polymerase I Transcription by the Tumor Suppressor p53. Mol. Cell. Biol. (UNITED STATES). August 2000, 20 (16): 5930–8. doi:10.1128/MCB.20.16.5930-5938.2000. ISSN 0270-7306. PMC 86070. PMID 10913176. 
  6. ^ Hannan, K M; Hannan R D, Smith S D, Jefferson L S, Lun M, Rothblum L I. Rb and p130 regulate RNA polymerase I transcription: Rb disrupts the interaction between UBF and SL-1. Oncogene (ENGLAND). October 2000, 19 (43): 4988–99. doi:10.1038/sj.onc.1203875. ISSN 0950-9232. PMID 11042686. 
  7. ^ Lin, Chih-Yin; Tuan JoAnn, Scalia Pierluigi, Bui Tiffany, Comai Lucio. The cell cycle regulatory factor TAF1 stimulates ribosomal DNA transcription by binding to the activator UBF. Curr. Biol. (England). Dec 2002, 12 (24): 2142–6. doi:10.1016/S0960-9822(02)01389-1. ISSN 0960-9822. PMID 12498690. 

延伸阅读[编辑]