卫生假说

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卫生假说英语hygiene hypothesis)是一种医学假说,指童年时因缺少接触传染源、共生微生物(如胃肠道菌群益生菌)与寄生物,从而抑制了免疫系统的正常发展,进而增加了感染过敏性疾病的可能性。[1]发达国家青少年自身免疫性疾病急性淋巴性白血病发病率的增加被认为与卫生假说有关。[2][3]一些证据表明自闭症是由免疫疾病导致的[4][5][6][7][8],有一项研究便支持卫生假说,认为这是导致自闭症的原因之一。[9]

参考文献[编辑]

  1. ^ Strachan DP. Family size, infection and atopy: the first decade of the "hygiene hypothesis". Thorax. 55. 2000-08,. Suppl 1 (90001): S2–10. doi:10.1136/thorax.55.suppl_1.S2. PMC 1765943. PMID 10943631. 
  2. ^ Evidence that childhood acute lymphoblastic leukemia is associated with an infectious agent linked to hygiene conditions. Smith MA, Simon R, Strickler HD, McQuillan G, Ries LA, Linet MS.National Cancer Institute, Division of Cancer Treatment and Diagnosis, Bethesda, MD 20892, USA.
  3. ^ The 'hygiene hypothesis' for autoimmune and allergic diseases: an update. Okada H, Kuhn C, Feillet H, Bach JF. INSERM U1013, Necker-Enfants Malades Hospital, Paris, France.
  4. ^ Croonenberghs J, Wauters A, Devreese K et al.. Increased serum albumin, gamma globulin, immunoglobulin IgG, and IgG2 and IgG4 in autism. Psychol Med. 2002, 32 (8): 1457–63. PMID 12455944. 
  5. ^ Gupta S, Aggarwal S, Rashanravan B, Lee T. Th1- and Th2- like cytokines in CD4+ and CD8+ T cells in autism. J Neuroimmunol 1998;85(1):106–9.
  6. ^ Ashwood P, Wakefield AJ. Immune activation of peripheral blood and mucosal CD3(+) lymphocyte cytokine profiles in children with autism and gastrointestinal symptoms. JNeuroimmunol 2006;173(1–2):126–34.
  7. ^ Zimmerman AW, Jyonouchi H, Comi AM et al.. Cerebrospinal fluid and serum markers of inflammation in autism. Pediatr Neurol. 2005, 33 (3): 195–201. doi:10.1016/j.pediatrneurol.2005.03.014. PMID 16139734. 
  8. ^ Molloy CA, Morrow AL, Meinzen-Derr J et al.. Elevated cytokine levels in children with autism spectrum disorder. J Neuroimmunol. 2006, 172 (1–2): 198–205. doi:10.1016/j.jneuroim.2005.11.007. PMID 16360218. 
  9. ^ "Autism, asthma, inflammation, and the hygiene hypothesis", Kevin G. Becker Gene Expression and Genomics Unit, RRB, TRIAD Technology Center, National Institute on Aging, National Institutes of Health, Room 208, 333 Cassell Drive, Baltimore, MD 21224, United States .