视网膜母细胞瘤蛋白

视网膜母细胞瘤蛋白
已知的结构
PDB	直系同源搜索: PDBe RCSB
PDBID列表
	1AD6、1GH6、1GUX、1H25、1N4M、1O9K、1PJM、2AZE、2QDJ、2R7G、3N5U、3POM、4ELJ、4ELL、4CRI
识别号
别名	RB1；, pRb, RB, retinoblastoma 1, OSRC, PPP1R130, p105-Rb, pp110, Retinoblastoma protein, RB transcriptional corepressor 1, p110-RB1
外部ID	OMIM：614041 MGI：97874 HomoloGene：272 GeneCards：RB1
相关疾病
	膀胱癌、lung small cell carcinoma、familial retinoblastoma
基因位置（人类）
染色体	13号染色体
终止	48,599,436 bp
基因位置（小鼠）
染色体	小鼠14号染色体
终止	73,563,262 bp
RNA表达模式
	; ;
	查阅更多表达数据
基因本体
分子功能	• DNA结合; • DNA结合转录因子活性; • 转录共激活因子活性; • 转录因子结合; • 磷蛋白结合; • 激酶结合; • 血浆蛋白结合; • 雄激素受体结合; • 相同蛋白质结合; • 酶结合; • 泛素蛋白连接酶结合; • importin-α家族蛋白结合; • 无序域特异性结合; • 核心启动子近端区域序列特异性DNA结合; • DNA结合转录阻遏物活性，RNA聚合酶II特异性;
细胞组分	• PML body; • SWI/SNF complex; • 转录调节复合物; • 纺锤体; • cyclin/CDK positive transcription elongation factor complex; • 染色质; • 细胞核; • 核质; • Rb-E2F complex;
生物学过程	• negative regulation of cell population proliferation; • negative regulation of mitotic cell cycle; • neuron apoptotic process; • androgen receptor signaling pathway; • 染色体重建; • negative regulation of smoothened signaling pathway; • negative regulation of protein kinase activity; • cell morphogenesis involved in neuron differentiation; • mitotic cell cycle checkpoint signaling; • regulation of transcription by RNA polymerase II; • positive regulation of macrophage differentiation; • cellular response to xenobiotic stimulus; • negative regulation of cell cycle; • negative regulation of DNA-binding transcription factor activity; • transcription, DNA-templated; • glial cell apoptotic process; • regulation of cohesin loading; • regulation of cell cycle; • neuron maturation; • 细胞分裂; • positive regulation of transcription, DNA-templated; • negative regulation of G1/S transition of mitotic cell cycle; • positive regulation of mitotic metaphase/anaphase transition; • regulation of centromere complex assembly; • enucleate erythrocyte differentiation; • neuron differentiation; • regulation of mitotic cell cycle; • negative regulation of epithelial cell proliferation; • skeletal muscle cell differentiation; • sister chromatid biorientation; • protein localization to chromosome, centromeric region; • 细胞周期; • striated muscle cell differentiation; • Ras protein signal transduction; • myoblast differentiation; • viral process; • negative regulation of transcription, DNA-templated; • neuron projection development; • digestive tract development; • maintenance of mitotic sister chromatid cohesion; • regulation of lipid kinase activity; • positive regulation of transcription by RNA polymerase II; • hepatocyte apoptotic process; • 细胞凋亡; • positive regulation of transcription regulatory region DNA binding; • negative regulation of gene expression; • regulation of cell growth; • tissue homeostasis; • regulation of transcription, DNA-templated; • G1/S transition of mitotic cell cycle; • negative regulation of transcription by RNA polymerase II; • negative regulation of transcription involved in G1/S transition of mitotic cell cycle; • chromatin organization; • aortic valve morphogenesis; • negative regulation of inflammatory response; • positive regulation of extracellular matrix organization; • positive regulation of collagen fibril organization; • negative regulation of myofibroblast differentiation; • 细胞分化; • negative regulation of cold-induced thermogenesis; • negative regulation of protein serine/threonine kinase activity; • negative regulation of tau-protein kinase activity; • negative regulation of apoptotic signaling pathway;
	Sources:Amigo / QuickGO
直系同源
	5925
	19645
	ENSG00000139687
	ENSMUSG00000022105
	P06400
	P13405
	NM_000321
	NM_009029
	NP_000312; NP_000312.2
	NP_033055
	维基数据
查看/编辑人类	查看/编辑小鼠

视网膜母细胞瘤蛋白（英语：retinoblastoma protein，常缩写为Rb、RB或RB1）又译为成视网膜细胞瘤蛋白是一种抑癌蛋白，并在几种主要的癌症发生时失活^[6]。Rb的功能之一是通过抑制细胞周期进程直到细胞准备妥当来防止细胞过度生长。当细胞准备好要分裂时，Rb蛋白会被磷酸化为pRb而失去抑制活性，从而使细胞周期进行下去。

Rb是袋状蛋白家族的一员，其特点是有一个口袋状的结构用以结合其它蛋白^[7]^[8]。使得一些致癌变蛋白，比如高危险群人类乳突病毒所感染的细胞产生的蛋白，结合并抑制pRb，最终导致癌症。

相互作用[编辑]

已知Rb蛋白与下列蛋白质有相互作用关系：

Abl gene^[9]^[10]
Androgen receptor^[11]^[12]
Apoptosis-antagonizing transcription factor^[13]^[14]
ARID4A^[15]
芳香烃受体^[16]
BRCA1^[17]^[18]^[19]
BRF1^[20]^[21]
C-jun^[22]
C-Raf^[23]^[24]
CDK9^[25]
CUTL1^[26]
周期蛋白A1^[27]
周期蛋白D1^[28]^[29]
周期蛋白T2^[25]
DNMT1^[30]
E2F1^[31]^[32]^[33]^[34]^[35]^[36]^[37]
E2F2,^[38]
E4F1^[34]
EID1^[39]^[40]
ENC1^[41]
FRK^[42]
HBP1^[43]
HDAC1^[15]^[44]^[45]^[46]^[47]^[48]^[49]
HDAC3^[15]^[50]
Histone deacetylase 2^[15]
胰岛素^[51]
JARID1A^[52]^[53]
LIN9^[54]
MCM7^[55]
MORF4L1^[32]^[56]
MRFAP1,^[32]^[56]
MyoD^[57]^[58]
NCOA6^[59]
PA2G4^[60]
过氧化物酶体增殖物活化受体γ^[50]
PIK3R3^[61]
Plasminogen activator inhibitor-2^[62]
Polymerase (DNA directed), alpha 1^[63]
PRDM2^[64]
PRKRA^[65]
Prohibitin^[24]^[66]
早幼粒细胞白血病蛋白^[67]
RBBP4^[31]^[68]
RBBP7^[19]^[68]
RBBP8^[44]^[69]
RBBP9^[70]
SNAPC1^[71]
SKP2^[72]^[73]
SNAPC3^[71]
SNW1^[74]
SUV39H1^[75]^[76]
TAF1^[28]^[77]^[78]^[79]
THOC1^[80]
TRAP1^[81]
TRIP11^[82]
UBTF^[83]
USP4.^[84]

参考文献[编辑]

^ 與视网膜母细胞瘤蛋白相關的疾病；在維基數據上查看/編輯參考.
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视网膜母细胞瘤蛋白引用了美国国家医学图书馆提供的资料，这些资料属于公共领域。

延伸阅读[编辑]

Momand J, Wu HH, Dasgupta G. MDM2—master regulator of the p53 tumor suppressor protein. Gene. 2000, 242 (1–2): 15–29. PMID 10721693. doi:10.1016/S0378-1119(99)00487-4.
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Lai H, Ma F, Lai S. Identification of the novel role of pRB in eye cancer. J. Cell. Biochem. 2003, 88 (1): 121–7. PMID 12461781. doi:10.1002/jcb.10283.
Simin K, Wu H, Lu L; et al. pRb Inactivation in Mammary Cells Reveals Common Mechanisms for Tumor Initiation and Progression in Divergent Epithelia. PLoS Biol. 2006, 2 (2): E22. PMC 340938 . PMID 14966529. doi:10.1371/journal.pbio.0020022.
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Clemo NK, Arhel NJ, Barnes JD; et al. The role of the retinoblastoma protein (Rb) in the nuclear localization of BAG-1: implications for colorectal tumour cell survival. Biochem. Soc. Trans. 2005, 33 (Pt 4): 676–8. PMID 16042572. doi:10.1042/BST0330676.
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外部链接[编辑]

医学主题词表（MeSH）：RB1+protein,+human
医学主题词表（MeSH）：Retinoblastoma+genes
GeneReviews/NIH/NCBI/UW entry on Retinoblastoma （页面存档备份，存于互联网档案馆）
Retinoblastoma Genetics （页面存档备份，存于互联网档案馆）
Drosophila Retinoblastoma-family protein - The Interactive Fly （页面存档备份，存于互联网档案馆）
Drosophila Retinoblastoma-family protein 2 - The Interactive Fly （页面存档备份，存于互联网档案馆）
Evolutionary Homologs Retinoblastoma-family proteins - The Interactive Fly （页面存档备份，存于互联网档案馆）
There is a diagram of the pRb-E2F interactions here^{[永久失效链接]}.

参见[编辑]

p53：参与pRb的DNA修复功能
转录辅助调节因子(transcription coregulator)
视网膜母细胞瘤

[1] 與视网膜母细胞瘤蛋白相關的疾病；在維基數據上查看/編輯參考.

[refGRCh38Ensembl-2] 2.0 ^2.1 ^2.2 GRCh38: Ensembl release 89: ENSG00000139687 - Ensembl, May 2017

[refGRCm38Ensembl-3] 3.0 ^3.1 ^3.2 GRCm38: Ensembl release 89: ENSMUSG00000022105 - Ensembl, May 2017

[4] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

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