模板:PBB/1956

Epidermal growth factor receptor; 表皮生長因子受體
	表皮生長因子受體的胞外結構域與表皮生長因子結合的複合體，引自PDB1nql
有效結構
PDB	直系同源檢索：PDBe, RCSB
PDB查詢代碼列表
	1IVO, 1M14, 1M17, 1MOX, 1NQL, 1XKK, 1YY9, 1Z9I, 2EB2, 2EB3, 2GS2, 2GS7, 2ITN, 2ITO, 2ITP, 2ITQ, 2ITT, 2ITU, 2ITV, 2ITW, 2ITX, 2ITY, 2ITZ, 2J5E, 2J5F, 2J6M, 2JIT, 2JIU, 2JIV, 2KS1, 2M0B, 2M20, 2RF9, 2RFD, 2RFE, 2RGP, 3B2U, 3B2V, 3BEL, 3BUO, 3C09, 3G5V, 3G5Y, 3GOP, 3GT8, 3IKA, 3LZB, 3NJP, 3OB2, 3OP0, 3P0Y, 3PFV, 3POZ, 3QWQ, 3UG1, 3UG2, 3VJN, 3VJO, 3VRP, 3VRR, 3W2O, 3W2P, 3W2Q, 3W2R, 3W2S, 3W32, 3W33, 4G5J, 4G5P, 4HJO, 4I1Z, 4I20, 4I21, 4I22, 4I23, 4I24, 4JQ7, 4JQ8, 4JR3, 4JRV, 4KRL, 4KRM, 4KRO, 4KRP, 4LI5, 4LL0
標識
代號	EGFR; ERBB; ERBB1; HER1; PIG61; mENA
擴展標識	遺傳學：131550 鼠基因：95294 同源基因：74545 ChEMBL: 203 GeneCards: EGFR Gene
EC編號	2.7.10.1
基因本體論描述
分子功能	· double-stranded DNA binding; · MAP kinase kinase kinase activity; · protein tyrosine kinase activity; · transmembrane receptor protein tyrosine kinase activity; · receptor signaling protein tyrosine kinase activity; · transmembrane signaling receptor activity; · epidermal growth factor-activated receptor activity; · protein binding; · ATP binding; · enzyme binding; · protein phosphatase binding; · nitric-oxide synthase regulator activity; · identical protein binding; · protein heterodimerization activity; · actin filament binding;
細胞成分	· Golgi membrane; · extracellular space; · nucleus; · cytoplasm; · endosome; · endoplasmic reticulum membrane; · plasma membrane; · endosome membrane; · membrane; · integral to membrane; · basolateral plasma membrane; · AP-2 adaptor complex; · nuclear membrane; · membrane raft; · perinuclear region of cytoplasm; · Shc-EGFR complex;
生物過程	· MAPK cascade; · activation of MAPKK activity; · ossification; · embryonic placenta development; · hair follicle development; · response to stress; · signal transduction; · cell surface receptor signaling pathway; · epidermal growth factor receptor signaling pathway; · activation of phospholipase C activity; · axon guidance; · salivary gland morphogenesis; · cell proliferation; · positive regulation of cell proliferation; · fibroblast growth factor receptor signaling pathway; · cell-cell adhesion; · cerebral cortex cell migration; · positive regulation of cell migration; · positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S; · positive regulation of catenin import into nucleus; · negative regulation of epidermal growth factor receptor signaling pathway; · negative regulation of protein catabolic process; · positive regulation of phosphorylation; · activation of phospholipase A2 activity by calcium-mediated signaling; · negative regulation of apoptotic process; · positive regulation of MAP kinase activity; · innate immune response; · positive regulation of nitric oxide biosynthetic process; · positive regulation of DNA repair; · positive regulation of DNA replication; · protein autophosphorylation; · neurotrophin TRK receptor signaling pathway; · phosphatidylinositol-mediated signaling; · positive regulation of fibroblast proliferation; · digestive tract morphogenesis; · positive regulation of epithelial cell proliferation; · regulation of peptidyl-tyrosine phosphorylation; · regulation of nitric-oxide synthase activity; · protein insertion into membrane; · positive regulation of protein kinase B signaling cascade; · morphogenesis of an epithelial fold; · response to UV-A;
	Sources: Amigo / QuickGO
RNA表達模式
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直系同源體
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^ Kathryn M. Ferguson, Mitchell B. Berger, Jeannine M. Mendrola, Hyun Soo Cho, Daniel J. Leahy, Mark A. Lemmon. EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization. Molecular Cell. 2003-02, 11 (2): 507–517 [2019-05-26]. ISSN 1097-2765. PMID 12620237.

[1] Kathryn M. Ferguson, Mitchell B. Berger, Jeannine M. Mendrola, Hyun Soo Cho, Daniel J. Leahy, Mark A. Lemmon. EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization. Molecular Cell. 2003-02, 11 (2): 507–517 [2019-05-26]. ISSN 1097-2765. PMID 12620237.

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