Α,α-二甲基色胺

维基百科,自由的百科全书
跳到导航 跳到搜索
Α,α-二甲基色胺
识别
CAS号 304-53-0  ✓
性质
化学式 C12H16N2
摩尔质量 188.27 g·mol−1
熔点 122~126 °C(395~399 K)[1]
若非注明,所有数据均出自一般条件(25 ℃,100 kPa)下。

α,α-二甲基色胺是一种有机化合物,化学式为C12H16N2,它是二甲基色胺同分异构体之一。它可由3-(2-甲基-2-硝基丙基)-1H-吲哚在催化下由氢气[2]水合肼[3]还原制得。它和1-(2,6-二甲基苯氧基)-2,3-环氧丙烷反应,可以得到1-(2,6-二甲基苯氧基)-3-[(2-(1H-吲哚-3-基)-1,1-二甲基乙基)氨基]2-丙醇。[1]

参考文献[编辑]

  1. ^ 1.0 1.1 William E. Kreighbaum, W. Lesley Matier, Ronald D. Dennis, Joseph L. Minielli, David Deitchman, James L. Perhach, William T. Comer. Antihypertensive indole derivatives of phenoxypropanolamines with .beta.-adrenergic receptor antagonist and vasodilating activity. Journal of Medicinal Chemistry. 1980-03, 23 (3): 285–289 [2021-07-22]. ISSN 0022-2623. doi:10.1021/jm00177a015 (英语). 
  2. ^ Radhe Shyam, Lionel Nauton, Gaetano Angelici, Olivier Roy, Claude Taillefumier, Sophie Faure. NC α‐ gem ‐dimethylated peptoid side chains: A novel approach for structural control and peptide sequence mimetics. Biopolymers. 2019-03-21, 110 (6) [2021-07-22]. ISSN 0006-3525. doi:10.1002/bip.23273. 
  3. ^ Bryan K. S. Yeung, Bin Zou, Matthias Rottmann, Suresh B. Lakshminarayana, Shi Hua Ang, Seh Yong Leong, Jocelyn Tan, Josephine Wong, Sonja Keller-Maerki, Christoph Fischli, Anne Goh, Esther K. Schmitt, Philipp Krastel, Eric Francotte, Kelli Kuhen, David Plouffe, Kerstin Henson, Trixie Wagner, Elizabeth A. Winzeler, Frank Petersen, Reto Brun, Veronique Dartois, Thierry T. Diagana, Thomas H. Keller. Spirotetrahydro β-Carbolines (Spiroindolones): A New Class of Potent and Orally Efficacious Compounds for the Treatment of Malaria. Journal of Medicinal Chemistry. 2010-06-22, 53 (14): 5155–5164 [2021-07-22]. ISSN 0022-2623. PMC 6996867. PMID 20568778. doi:10.1021/jm100410f.