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α-胎兒蛋白

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AFP
已知的結構
PDB Ortholog search: PDBe RCSB
識別號
别名 AFP;AFPD、​FETA、​HPAFP、​alpha fetoprotein
外部ID OMIM104150 MGI87951 HomoloGene36278 GeneCardsAFP
RNA表达模式
PBB GE AFP 204694 at fs.png
更多參考(基因)表达數據
直系同源
物種 人類 小鼠
Entrez
Ensembl
UniProt
mRNA​序列

NM_001134、NM_001354717

NM_007423

蛋白序列

NP_001125、NP_001341646

NP_031449

基因位置​(UCSC) Chr 4: 73.43 – 73.46 Mb n/a
PubMed​查找 [1] [2]
維基數據
檢視/編輯 人類 檢視/編輯 小鼠

α-胎兒蛋白(英語:Alpha-Fetoprotein,縮寫AFP;又譯甲種胎儿球蛋白甲胎蛋白)是一種α-1球蛋白,由胎兒腸胃道、卵黃囊肝臟分泌,但可經由腎臟排入尿液羊水,並通過胎盤進入母體血流中。在正常妊娠時,胎兒血清中之胎兒蛋白濃度於12至14週間達到最高,而母體血清中之濃度則於28至32週間達到最高。如果羊水或母體血清中α-胎兒蛋白超過正常範圍,需考慮胎兒發育異常;諸如:神經管缺損先天性腎病變腸道閉鎖死胎胎兒窘迫……等。也就是說,α-胎兒蛋白雖是一項非特異指標,但對於產前評估胎兒健康狀態甚具臨床價值,也是幫助檢查胎兒異常之一項篩檢工具。

許多肝病皆可能伴隨α-胎兒蛋白之升高,因此可作為臨床參考。例如80%~90%的肝細胞癌病人,其血液中α-胎兒蛋白有升高之現象,故在肝病甚為流行的區域(如台灣),利用α-胎兒蛋白及超音波作為高危險群病人篩檢方式,成效不錯。再如肝硬化病人當中有些合併有α-胎兒蛋白之升高,其可能代表肝細胞再生的持續進行但若持續地上升﹐則須積極追縱,找出可能的惡性變化。此外,急慢性肝炎患者,其血中α-胎兒蛋白常隨著肝細胞壞死後之再生而升高。其高峰往往在轉氨基的高峰之後;其升高程度間接地反應肝細胞壞死後的再生能力,也因此常被利用作為病理變化及病程預後之參考。

參考文獻[编辑]

延伸阅读[编辑]

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