丙帕他莫

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丙帕他莫
Propacetamol-2d-skeletal.png
系统(IUPAC)命名名称
4-(acetamido)phenyl N,N-diethylglycinate
临床数据
Drugs.com国际药品名称
给药途径IV[1][2]
药代动力学数据
生物半衰期2.4小時 [1]
排泄經由腎臟
识别信息
CAS注册号66532-85-2
ATC代码N02BE05
PubChemCID 68865
ChemSpider62097
UNII5CHW4JMR82 ✓
化学信息
化学式C14H20N2O3
摩尔质量264.33 g·mol−1

丙帕他莫扑热息痛前药,由扑热息痛和羧酸二乙基甘氨酸酯化形成。这具有使其更易溶于水的优点。它用于术后透过静脈注射护理无法以口服或直肠给药扑热息痛,并且禁用非甾体抗炎药(NSAID)的患者。丙帕他莫起效比口服扑热息痛快。 [3] 2克丙帕他莫相当于1 克扑热息痛的藥效。 [4]

相關條目[编辑]

参考資料[编辑]

  1. ^ 1.0 1.1 Bannwarth B, Netter P, Lapicque F, Gillet P, Péré P, Boccard E, Royer RJ, Gaucher A. Plasma and cerebrospinal fluid concentrations of paracetamol after a single intravenous dose of propacetamol. British Journal of Clinical Pharmacology. 1992, 34 (1): 79–81. PMC 1381380. PMID 1633071. doi:10.1111/j.1365-2125.1992.tb04112.x. 
  2. ^ Binhas M, Decailliot F, Rezaiguia-Delclaux S, Suen P, Dumerat M, François V, Combes X, Duvaldestin P. Comparative effect of intraoperative propacetamol versus placebo on morphine consumption after elective reduction mammoplasty under remifentanil-based anesthesia: a randomized control trial [ISRCTN71723173]. BMC Anesthesiology. 2004, 4 (1): 6. PMC 520811. PMID 15367329. doi:10.1186/1471-2253-4-6. 
  3. ^ Onset of acetaminophen analgesia: comparison of oral and intravenous routes after third molar surgery. British Journal of Anaesthesiology. 2005, 94 (5): 642–648. PMID 15790675. doi:10.1093/bja/aei109.  无效|subscription=free (帮助)
  4. ^ Bioequivalence study comparing a new paracetamol solution for injection and propacetamol after single intravenous infusion in healthy subjects. International Journal of Clinical Pharmacology and Therapeutics. 2004, 42 (1): 50–57. PMID 14756388. doi:10.5414/cpp42050.