- Dil Ka Rishta （2002年）── 同Aishwarya Rai以及Arjun Rampal作對手戲，出演反角
- Qayamat: City Under Threat （2003年）──出任反角並獲得Filmfare《最佳反派角色獎》
- Girlfriend （2003年）── 扮演身體強健的女同性戀者
- Maine Pyar Kyun Kiya （2005年）── 與薩爾曼·汗同戲中演出
- Kyaa Kool Hai Hum （2006年）── 扮演戲劇性的女警察，獲得三項電影獎的提名
|2008年||Right or Wrong||Announced|
|2007年||Shabri||Shabri||To Be Released in October 2007|
|2007年||Hello||Esha||To Be Released in January 2008|
|2007年||Haseena - Smart, Sexy, Dangerous||Haseena|
|2007年||Salaam-e-Ishq: A Tribute To Love||Phoolwati|
|2006年||Don - The Chase Begins Again||Anita|
|2006年||36 China Town||Sonia Chang|
|2005年||Maine Pyar Kyun Kiya?||Vicky's Girlfriend|
|2005年||Kyaa Kool Hai Hum||Urmila Martodkar|
|2004年||Inteqam: The Perfect Game||Avantika Suryavansh/Pinky|
|2004年||Ek Se Badhkar Ek||Tracy/Shalini Mathur|
|2004年||Hum Tum||Diana Fernandez||Special Appearance|
|2003年||Darna Mana Hai||Abhilasha|
|2003年||Qayamat: City Under Threat||Laila|
|2003年||Dil Ka Rishta||Anita|
|2002年||Kaante||Item number (Song 'Ishq Samundar')|
|2002年||Company||Item number (Song 'Khallas!')|
|2001年||Aamdani Atthanni Kharcha Rupaiya||Anjali|
|2001年||Pyaar Ishq Aur Mohabbat||Rubaina|
|2001年||Rahul||Item number (Song 'Piya Ki Jogan')|
|2000年||O Nanna Nalle||Rangu||Kannada|
|2000年||Hoo Anthiya Uhoo Anthiya||Kannada|
|1998年||En Swaasa Katrae||Madhu||Tamil|
Ishaa Koppikar's career started in Kollywood, where she was paired opposite Prashanth in Kaadhal Kavidai. A lot of the film was shot in London and became a blockbuster following its release, winning the lead actors rave reviews and Koppikar winning the Filmfare Best Female Debut (Tamil). With this, Ishaa was touted to be the next non-Tamil girl after Simran Bagga,who would take over the Tamil film industry. Her second movie was the highly-anticipated Tamil film, En Swasa Katre opposite Arvind Swamy, one of the most successful actors at that time. The film was a musical hit, rendered by A. R. Rahman, and a good grosser at the box-office. She then played a cameo in Prashanth's Jodi as a prospective bride. She received positive reviews for her role and decided to pursue a career in Bollywood: Her first Hindi movie was Ek Tha Dil Ek Thi Dhadkan (1997), directed by Shah Rukh Sultan, and yet to be released.
Koppikar appeared in minor roles in Fiza (2000), Pyaar Ishq aur Mohabbat and Aamdani Atthanni Kharcha Rupaiya (2001). In 2002, she appeared in Ram Gopal Varmas Company as an Item girl in the song Khallas!. The number created her nickname Khallas-girl and caused her breakthrough. In 2003 she won 'Most Exciting New Face' for Khallas at the Stardust Awards.
In Dil Ka Rishta she played opposite Aishwarya Rai and Arjun Rampal and for her negative role in Qayamat: City Under Threat (2003), she received a nomination for Filmfare Best Villain Award. In the movie Girlfriend (2004), she played a woman involved in a lesbian relationship. For the role she built up her body to display some impressive muscles and performed her own stunts and fight scenes. In D (2004), she again worked with Ram Gopal Varma in the prequel of his movie Company.
In 2005 she played Arshad Warsi's girlfriend in the Salman Khan starrer Maine Pyar Kyun Kiya?. In the same year she appeared opposite Anupam Kher and Tusshar Kapoor in the comedy Kyaa Kool Hai Hum. For her role as policewoman Urmila Martodkar she received three award nominations for best comedy. A special appearance, playing casino owner Sonia Chang, in 36 China Town preceded her biggest release to date, in 2006, in Farhan Akhtar's Don cast alongside Shahrukh Khan as Don's girlfriend, Anita. Her role was expanded to one bigger than that in the original 1978 version with Amitabh Bachchan. At the start of 2007 she replaced Perizaad Zorabian in a minor role in Nikhil Advani's Salaam-e-Ishq: A Tribute To Love opposite Sohail Khan. This was her third appearance with Khan, having worked with him in Krishna Cottage (2004) and Maine Pyaar Kyun Kiya.
She will feature as the female lead in Ram Gopal Varma's Shabri (2007), a movie about a woman who is set to become Mumbai's first underworld lord. Koppikar's make-up was so convincing that security and producers wouldn't let her enter the set, as they didn't recognize her.
Koppikar has two films under production in 2007 in which she has replaced actresses withdrawing from the roles. Bipasha Basu was replaced in Darling, directed by Ram Gopal Varma and co-starring Fardeen Khan and Esha Deol. And Celina Jaitley was replaced in Atul Agnihotri's Hello, co-starring Sohail Khan. After a three year wait Haseena Smart Sexy and Dangerous was finally released with Ishaa in the title role. She is also doing Rajshri Productions next co staring Sonu Sood.
- 2001年~02年音樂舞台劇《Patli Kamar》
- 2004年《Bhor (Satyam Shivam Sundaram)》——Bandish Projekt製作
- 2006年參加《Indian Idol》──決賽之夜演出。