促甲状腺激素释放激素受体

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Thyrotropin-releasing hormone receptor
促甲状腺激素释放激素受体
标识
代号 TRHR; TRH-R
扩展标识 遗传学188545 鼠基因98824 同源基因20707 IUPHAR:  TRH1 ChEMBL英语ChEMBL: 1810 GeneCards: TRHR Gene
RNA表达模式
PBB GE TRHR 211438 at tn.png
更多表达数据
直系同源体
物种 人类 小鼠
Entrez 7201 22045
Ensembl ENSG00000174417 ENSMUSG00000038760
UniProt P34981 P21761
mRNA序列 NM_003301 NM_013696
蛋白序列 NP_003292 NP_038724
基因位置 Chr 8:
110.1 – 110.13 Mb
Chr 15:
44.2 – 44.24 Mb
PubMed查询 [1] [2]

促甲状腺激素释放激素受体英语:thyrotropin-releasing hormone receptorTRHR)是一种与三肽促甲状腺激素释放激素结合的G蛋白偶联受体[1][2]。TRHR表达于细胞中,在与TRH结合时会激活磷脂酶C英语phospholipase C增加细胞内肌醇三磷酸含量。

参考文献[编辑]

  1. ^ Yamada M, Monden T, Konaka S, Mori M. Assignment of human thyrotropin-releasing hormone (TRH) receptor gene to chromosome 8. Somat. Cell Mol. Genet. 1993, 19 (6): 577–80. PMID 8128317. doi:10.1007/BF01233384. 
  2. ^ Gershengorn MC. Thyrotropin-releasing hormone receptor: cloning and regulation of its expression. Recent Prog. Horm. Res. 1993, 48: 341–63. PMID 8382829. 

延伸阅读[编辑]

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  • Kroeger KM, Hanyaloglu AC, Seeber RM; 等. Constitutive and agonist-dependent homo-oligomerization of the thyrotropin-releasing hormone receptor. Detection in living cells using bioluminescence resonance energy transfer.. J. Biol. Chem. 2001, 276 (16): 12736–43. PMID 11278883. doi:10.1074/jbc.M011311200. 
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