周期蛋白A1

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Cyclin A1
周期素A1
标识
代号 CCNA1
扩展标识 遗传学604036 鼠基因108042 同源基因31203 ChEMBL: 3609 GeneCards: CCNA1 Gene
RNA表达模式
PBB GE CCNA1 205899 at tn.png
更多表达数据
直系同源体
物种 人类 小鼠
Entrez 8900 12427
Ensembl ENSG00000133101 ENSMUSG00000027793
UniProt P78396 Q61456
mRNA序列 NM_001111045 NM_007628
蛋白序列 NP_001104515 NP_031654
基因位置 Chr 13:
37.01 – 37.02 Mb
Chr 3:
55.05 – 55.06 Mb
PubMed查询 [1] [2]

周期蛋白A1英语Cyclin-A1,或译为周期素A1)是一个由人类基因 CCNA1 编码的蛋白质[1]

该基因编码的蛋白质属于高度保守的周期蛋白家族,该家族成员的显著特征是贯穿细胞周期,其蛋白质丰度周期性地急剧改变。周期蛋白作为CDK(周期蛋白依赖性激酶)的调节因子。不同的周期蛋白表现出各自独特的表达及降解特性,这有助于每个有丝分裂事件在时间上的协调性。周期蛋白A1表达于睾丸、大脑以及一些严重的白血病细胞系中,现任为其主要功能是控制减数分裂。该周期蛋白与Cdk1Cdk2两种激酶相结合,但这两种激酶活性完全不相同,前者激酶活性表现于G2期,而后者激酶活性表现于S期,因此在细胞周期中调控了不同的功能。现发现这种周期蛋白可结合到重要的细胞周期调节物上,后者如:Rb家族蛋白、转录因子E2F1以及CDK抑制蛋白中的Kip/Cip家族[2]

相互作用[编辑]

周期蛋白A1能与E2F1[3]CDC20[4]视网膜母细胞瘤蛋白[3]周期蛋白依赖性激酶2英语Cyclin-dependent kinase 2[1][5][6][7]GPS2英语GPS2 (gene)[8] MYBL2[6]GNB2L1[8]发生相互作用

参考文献[编辑]

  1. ^ 1.0 1.1 Yang R, Morosetti R, Koeffler HP. Characterization of a second human cyclin A that is highly expressed in testis and in several leukemic cell lines. Cancer Res. March 1997, 57 (5): 913–20. PMID 9041194. 
  2. ^ Entrez Gene: CCNA1 cyclin A1. 
  3. ^ 3.0 3.1 Yang, R; Müller C, Huynh V, Fung Y K, Yee A S, Koeffler H P. Functions of cyclin A1 in the cell cycle and its interactions with transcription factor E2F-1 and the Rb family of proteins. Mol. Cell. Biol. (UNITED STATES). March 1999, 19 (3): 2400–7. ISSN 0270-7306. PMC 84032. PMID 10022926. 
  4. ^ Ohtoshi, A; Maeda T, Higashi H, Ashizawa S, Hatakeyama M. Human p55(CDC)/Cdc20 associates with cyclin A and is phosphorylated by the cyclin A-Cdk2 complex. Biochem. Biophys. Res. Commun. (UNITED STATES). February 2000, 268 (2): 530–4. doi:10.1006/bbrc.2000.2167. ISSN 0006-291X. PMID 10679238. 
  5. ^ Sweeney, C; Murphy M, Kubelka M, Ravnik S E, Hawkins C F, Wolgemuth D J, Carrington M. A distinct cyclin A is expressed in germ cells in the mouse. Development (ENGLAND). January 1996, 122 (1): 53–64. ISSN 0950-1991. PMID 8565853. 
  6. ^ 6.0 6.1 Müller-Tidow, C; Wang W, Idos G E, Diederichs S, Yang R, Readhead C, Berdel W E, Serve H, Saville M, Watson R, Koeffler H P. Cyclin A1 directly interacts with B-myb and cyclin A1/cdk2 phosphorylate B-myb at functionally important serine and threonine residues: tissue-specific regulation of B-myb function. Blood (United States). April 2001, 97 (7): 2091–7. doi:10.1182/blood.V97.7.2091. ISSN 0006-4971. PMID 11264176. 
  7. ^ Brown, N R; Noble M E, Endicott J A, Johnson L N. The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases. Nat. Cell Biol. (England). November 1999, 1 (7): 438–43. doi:10.1038/15674. ISSN 1465-7392. PMID 10559988. 
  8. ^ 8.0 8.1 Diederichs, Sven; Bäumer Nicole, Ji Ping, Metzelder Stephan K, Idos Gregory E, Cauvet Thomas, Wang Wenbing, Möller Maria, Pierschalski Sarah, Gromoll Jörg, Schrader Mark G, Koeffler H Phillip, Berdel Wolfgang E, Serve Hubert, Müller-Tidow Carsten. Identification of interaction partners and substrates of the cyclin A1-CDK2 complex. J. Biol. Chem. (United States). August 2004, 279 (32): 33727–41. doi:10.1074/jbc.M401708200. ISSN 0021-9258. PMID 15159402. 

延伸阅读[编辑]