志賀毒素

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痢疾志贺氏菌S. dysenteriae)志賀毒素的飄帶圖,源自PDB 1R4Q数据库
志賀样毒素alpha亚基
鑑定
標誌SLT_alpha
InterPro英语InterProIPR016331
 SCOP英语Structural Classification of Proteins1r4q / SUPFAM
志賀样毒素beta亚基
鑑定
標誌SLT_beta
PfamPF02258
InterPro英语InterProIPR003189
 SCOP英语Structural Classification of Proteins2bos / SUPFAM
 TCDB英语TCDB1.C.54

志賀毒素(英語:Shiga toxin,簡寫為STX)是由志賀氏菌屬等细菌所分泌的外毒素,由α和β亚基組合而成,位于细菌基因组原噬菌体[1],这一蛋白最早由志賀潔发现[2]。过去常把大腸桿菌分泌的志賀毒素称为志賀样毒素Shiga-like toxinSLT),但现在这一词已不常用,能产生志賀毒素的大腸桿菌有O157:H7型O104:H4型[3][4][5]

参考文献[编辑]

  1. ^ Friedman D; Court D. Bacteriophage lambda: alive and well and still doing its thing. Current Opinion in Microbiology. 2001, 4 (2): 201–7. PMID 11282477. doi:10.1016/S1369-5274(00)00189-2. 
  2. ^ Trofa, Andrew F.; Ueno-Olsen, Hannah; Oiwa, Ruiko; Yoshikawa, Masanosuke. Dr. Kiyoshi Shiga: Discoverer of the Dysentery Bacillus. Clinical Infectious Diseases. 1999-11-01, 29 (5): 1303–1306. ISSN 1058-4838. PMID 10524979. doi:10.1086/313437 (英语).  已忽略未知参数|doi-access= (帮助)
  3. ^ Zhu Q; Li L; Guo Z; Yang R. Identification of Shiga-like toxin Escherichia coli isolated from children with diarrhea by polymerase chain reaction. Chin. Med. J. June 2002, 115 (6): 815–8. PMID 12123543. 
  4. ^ Beutin L. Emerging enterohaemorrhagic Escherichia coli, causes and effects of the rise of a human pathogen. Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health. 2006, 53 (7): 299–305. PMID 16930272. doi:10.1111/j.1439-0450.2006.00968.x. 
  5. ^ Spears; 等. A comparison of Enteropathogenic and enterohaemorragic E.coli pathogenesis. FEMS Microbiology Letters. 2006, 255 (2): 187–202. PMID 16448495. doi:10.1111/j.1574-6968.2006.00119.x.  已忽略未知参数|doi-access= (帮助)