核苷三磷酸還原酶

维基百科,自由的百科全书
跳到导航 跳到搜索
核苷三磷酸還原酶
Ribonucleoside-triphosphate reductase
识别码
EC編號 1.17.4.2
CAS号 9068-66-0
数据库
IntEnz IntEnz浏览
BRENDA英语BRENDA BRENDA入口
ExPASy英语ExPASy NiceZyme浏览
KEGG KEGG入口
MetaCyc英语MetaCyc 代谢路径
PRIAM英语PRIAM_enzyme-specific_profiles 概述
PDB RCSB PDB PDBj PDBe PDBsum

核苷三磷酸還原酶Ribonucleoside-triphosphate reductase)(EC 1.17.4.2ribonucleotide reductase, 2'-deoxyribonucleoside-triphosphate:oxidized-thioredoxin 2'-oxidoreductase),系統名「2-2'-脫氧核糖核苷三磷酸:硫氧還蛋白二硫鍵-2'-氧化還原酶」(2'-deoxyribonucleoside-triphosphate:thioredoxin-disulfide 2'-oxidoreductase[1][2][3],係一種能催化以下化學反應的

2'-脫氧核糖核苷三磷酸+硫氧化還原蛋白二硫鍵+H2O 核糖核苷三磷酸+硫氧化還原蛋白

核苷三磷酸還原酶的作用需要cobamide輔酶,同時還要消耗ATP

參考[编辑]

  1. ^ Blakley, R.L. Cobamides and ribonucleotide reduction. I. Cobamide stimulation of ribonucleotide reduction in extracts of Lactobacillus leichmannii. J. Biol. Chem. 1965, 240: 2173–2180. PMID 14299643. 
  2. ^ Goulian, M. and Beck, W.S. Purification and properties of cobamide-dependent ribonucleotide reductase from Lactobacillus leichmannii. J. Biol. Chem. 1966, 241: 4233–4242. PMID 5924645. 
  3. ^ Lammers, M. and Follmann, H. The ribonucleotide reductases - a unique group of metalloenzymes essential for cell-proliferation. Struct. Bonding. 1983, 54: 27–91. doi:10.1007/bfb0111318. 

外部連結[编辑]