名稱 |
來源 [1] |
目標受體[1][2] |
目標細胞[1] |
功能[1] |
IL-1 |
巨噬細胞、B細胞、单核细胞[3]、樹狀細胞。[3] |
CD121a/IL1R1、CD121b/IL1R2 |
輔助T細胞 |
共同刺激 [3] |
B細胞 |
成熟和增生 [3] |
自然殺手細胞 |
活化[3] |
巨噬細胞、內皮細胞,和其他細胞 |
發炎、[3]少量急性期反應,大量將導致發燒 |
IL-2 |
輔助型T細胞(TH1-cells) |
CD25/IL2RA、CD122/IL2RB、CD132/IL2RG |
活化的[3]T細胞、B細胞、自然殺手細胞、巨噬細胞、寡突膠細胞 |
刺激T細胞增生和分化[4]。可以用在免疫療法治療癌症,或移植器官必須降低免疫反應的病人。
也可用於臨床試驗(ESPIRIT. Stalwart)以提高HIV陽性患者的CD4數量。
|
IL-3 |
活化的輔助型T細胞、[3] 肥大細胞、自然殺手細胞、內皮細胞、嗜酸性球 |
CD123/IL3RA、CD131/IL3RB |
造血幹細胞 |
引發骨髓前驅細胞分化和增生[3]為紅血球、顆粒球 |
肥大細胞 |
增生、釋放出組織胺[3] |
IL-4 |
Th2細胞、剛活化的純真CD4+細胞、記憶輔助T細胞、肥大細胞、巨噬細胞 |
CD124/IL4R、CD132/IL2RG |
活化B細胞 |
增殖及分化,IgG1和IgE合成。[3] 引起過敏反應的重要角色(IgE) |
T細胞 |
增生[3]、誘導T細胞分化成輔助T2細胞[4] |
內皮細胞 |
|
IL-5 |
Th2細胞、肥大細胞、嗜酸性球 |
CD125/IL5RA、CD131/IL3RB |
嗜酸性球 |
製造 |
B細胞 |
發話、IgA製造 |
IL-6 |
巨噬細胞、Th2細胞、B細胞、星形膠質細胞、內皮細胞 |
CD126/IL6RA、CD130/IR6RB |
活化的B細胞 |
分化為漿細胞 |
漿細胞 |
抗體分泌 |
造血幹細胞 |
分化 |
T細胞和其他細胞 |
誘發急性期蛋白、造血作用、分化、發炎 |
IL-7 |
Bone marrow stromal cells and thymus stromal cells |
CD127/IL7RA、CD132/IL2RG |
pre/pro-B cell, pre/pro-T cell、自然殺手細胞 |
differentiation and proliferation of lymphoid progenitor cells, involved in B, T, and NK cell survival, development, and homeostasis, ↑proinflammatory cytokines |
IL-8 (CXCL8) |
巨噬細胞、淋巴球、上皮細胞、內皮細胞 |
CXCR1/IL8RA, CXCR2/IL8RB/CD128 |
嗜中性球、嗜鹼性球、淋巴球 |
嗜中性球趋化因子 |
IL-9 |
Th2細胞,特別是輔助T細胞 |
CD129/IL9R |
T細胞、B細胞 |
Potentiates IgM, IgG, IgE, stimulates 肥大細胞 |
IL-10 |
單核细胞、Th2細胞、细胞毒性T细胞、肥大細胞、巨噬細胞、B細胞 subset |
CD210/IL10RA、CDW210B/IL10RB |
巨噬細胞 |
cytokine production[3] |
B細胞 |
活化 [3] |
肥大細胞 |
|
Th1細胞 |
inhibits Th1 cytokine production (IFN-γ, TNF-β, IL-2) |
Th2細胞 |
刺激 |
IL-11 |
骨髓基質 |
IL11RA |
骨髓基質細胞 |
acute phase protein production, osteoclast formation |
IL-12 |
樹突狀細胞、B細胞、T細胞、巨噬細胞 |
CD212/IL12RB1, IR12RB2 |
活化的[3]T細胞 |
differentiation into Cytotoxic T cells with IL-2,[3] ↑ IFN-γ, TNF-α, ↓ IL-10 |
自然殺手細胞 |
↑ IFN-γ, TNF-α |
IL-13 |
活化的Th2細胞、肥大細胞、自然殺手細胞 |
IL13R |
TH2-cells, B cells, macrophages |
Stimulates growth and differentiation of B細胞 (IgE), inhibits TH1-cells and the production of macrophage inflammatory cytokines (e.g. IL-1, IL-6), ↓ IL-8, IL-10, IL-12 |
IL-14 |
T cells and certain malignant B cells |
|
activated B cells |
controls the growth and proliferation of B細胞, inhibits Ig secretion |
IL-15 |
mononuclear phagocytes (and some other cells), especially macrophages following infection by virus(es) |
IL15RA |
T cells, activated B cells |
Induces production of 自然杀伤细胞 |
IL-16 |
lymphocytes, epithelial cells, eosinophils, CD8+ T cells |
CD4 |
CD4+ T cells (Th-cells) |
CD4+ chemoattractant |
IL-17 |
T helper 17 cells (Th17) |
CDw217/IL17RA, IL17RB |
epithelium, endothelium, other |
osteoclastogenesis, 血管新生, ↑ inflammatory 細胞激素 |
IL-18 |
巨噬細胞 |
CDw218a/IL18R1 |
Th1細胞、自然殺手細胞 |
Induces production of IFNγ, ↑ NK cell activity |
IL-19 |
- |
IL20R |
|
- |
IL-20 |
Activated keratinocytes and monocytes |
IL20R |
|
regulates proliferation and differentiation of 角化细胞 |
IL-21 |
活性輔助T細胞、自然殺手T細胞 |
IL21R |
All lymphocytes, dendritic cells |
costimulates activation and proliferation of CD8+ T cells, augment NK cytotoxicity, augments CD40-driven B cell proliferation, differentiation and isotype switching, promotes differentiation of Th17 cells |
IL-22 |
T helper 17 cells (Th17) |
IL22R |
|
Production of defensins from epithelial cells.[5] Activates STAT1 and STAT3 and increases production of acute phase proteins such as serum amyloid A, Alpha 1-antichymotrypsin and haptoglobin in hepatoma cell lines |
IL-23 |
巨噬細胞、樹狀細胞 |
IL23R |
|
Maintenance of IL-17 producing cells,[5] increases 血管新生 but reduces CD8 T-cell infiltration |
IL-24 |
黑素細胞、角化细胞、单核细胞、T細胞 |
IL20R |
|
Plays important roles in 抑癌基因, wound healing and 銀屑病 by influencing cell survival, inflammatory cytokine expression. |
IL-25 |
T細胞、肥大細胞、嗜酸性球、巨噬細胞、黏膜上皮細胞 |
LY6E |
|
Induces the production IL-4, IL-5 and IL-13, which stimulate 嗜酸性球 expansion |
IL-26 |
T細胞、单核细胞 |
IL20R1 |
|
Enhances secretion of IL-10 and IL-8 and cell surface expression of CD54 on epithelial cells |
IL-27 |
巨噬細胞、樹突狀細胞 |
IL27RA |
|
调节B细胞和T细胞的活性 |
IL-28 |
- |
IL28R |
|
在抗病毒免疫中起作用 |
IL-29 |
- |
|
|
在抗微生物免疫中起作用 |
IL-30 |
- |
|
|
IL-27的單链 |
IL-31 |
Th2 cells |
IL31RA |
|
引起皮膚發炎 |
IL-32 |
- |
|
|
誘使單核细胞和巨噬細胞分泌TNF-α、IL-8,和CXCL2 |
IL-33 |
- |
|
|
誘使輔助T細胞製造第二型細胞因子 |
IL-35 |
调节T细胞 |
|
|
抑制T細胞活化 |
IL-36 |
- |
|
|
調控樹突狀細胞和T細胞的反應 |