The IL-2 Receptor (IL-2R) α subunit has low affinity for its ligand but has the ability (when bound to the β and ϒ subunit) to increase the IL-2R affinity 100-fold. Heterodimerization of the β and ϒ subunits of IL-2R is essential for signalling in T cells.
截止1993年，Proleukin仍是唯一获得批准的IL-2药物，但此时罗氏也开发了自己的修饰重组的IL-2（在氨基端增加了甲硫氨酸）商品名为teceleukin，and Glaxo was developing a version called bioleukin, with a methionine added at is N-terminal and residue 125 replaced with alanine. Dozens of clinical trials had been conducted of recombinant or purified IL-2, alone, in combination with other drugs, or using cell therapies, in which cells were taken from patients, activated with IL-2, then reinfused.Novartis acquired Chiron in 2006 and sold the aldesleukin business to Prometheus Laboratories in 2010.
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