美西林

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美西林
Mecillinam.svg
Mecillinam-3D-balls.png
系统(IUPAC)命名名称
(2S,5R,6R)-6-[(E/Z)-(Azepan-1-ylmethylene)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
临床数据
商品名 Coactin, Leo, Selexid, Selexidin
Drugs.com 国际药品名称
妊娠分级
给药途径 靜脈注射肌肉注射
合法狀態
合法状态
药代动力学数据
生物利用度 可忽略
蛋白结合度 5-10%
代谢 肝臟
生物半衰期 1-3小時
排泄 腎、膽
识别信息
CAS注册号32887-01-7 ✓
ATC代码 J01CA11
PubChem CID 36273
DrugBank DB01163 ✓
ChemSpider 33357 ✗
UNII V10579P3QZ ✗
KEGG D02888 ✗
ChEMBL英语ChEMBL CHEMBL530 ✓
化学信息
化学式 C15H23N3O3S
摩尔质量 325.426 g/mol
 ✗✓ (what is this?)英语Wikipedia:WikiProject_Chemicals/Chembox_validation  (verify)

美西林INN:Mecillinam;USAN:Amdinocillin)是一種广谱半合成青霉素[2],對革兰氏阴性菌作用强,也可用來治療傷寒副伤寒[3][4]。其口服利用率很差,匹美西林則是針對此缺陷開發出來的。[5]

這種藥物是荷蘭製藥公司“Leo Pharmaceutical Products”(今利奥制药)研發出來的,最初代號為FL 1060,1972年面世。[6][7]

參考文獻[编辑]

  1. ^ Nicolle LE. Pivmecillinam in the treatment of urinary tract infections. J Antimicrob Chemother. August 2000, 46 (Suppl A): 35–39. PMID 10969050. doi:10.1093/jac/46.suppl_1.35. 
  2. ^ Neu HC. Amdinocillin: a novel penicillin. Antibacterial activity, pharmacology and clinical use. Pharmacotherapy. 1985, 5 (1): 1–10. PMID 3885172. doi:10.1002/j.1875-9114.1985.tb04448.x. 
  3. ^ Clarke PD, Geddes AM, McGhie D, Wall JC. Mecillinam: a new antibiotic for enteric fever. Br Med J. July 1976, 2 (6026): 14–5. PMC 1687648. PMID 820402. doi:10.1136/bmj.2.6026.14. 
  4. ^ Geddes AM, Clarke PD. The treatment of enteric fever with mecillinam. J Antimicrob Chemother. July 1977,. 3 Suppl B: 101–2. PMID 408321. doi:10.1093/jac/3.suppl_b.101. 
  5. ^ Pham P, Bartlett JG. Amdinocillin (Mecillinam). Point-of-Care Information Technology ABX Guide. Johns Hopkins University. August 28, 2008.  Retrieved on August 31, 2008. Freely available with registration.
  6. ^ Lund F, Tybring L. 6β-amidinopenicillanic acids—a new group of antibiotics. Nature New Biology. April 1972, 236 (66): 135–7. PMID 4402006. doi:10.1038/236135c0. 
  7. ^ Tybring L, Melchior NH. Mecillinam (FL 1060), a 6β-Amidinopenicillanic Acid Derivative: Bactericidal Action and Synergy In Vitro. Antimicrob Agents Chemother. September 1975, 8 (3): 271–6. PMC 429305. PMID 170856. doi:10.1128/aac.8.3.271.