葡萄糖依赖性促胰岛素多肽

胃抑素
已知的结构
PDB	直系同源搜索：PDBe RCSB
PDBID列表
	2L71、2B4N、2OBU、2QKH、2L70、1T5Q
标识符
代号	GIP、抑胃肽
扩展标识	OMIM：137240；MGI：107504；HomoloGene：3043；GeneCards：GIP；OMA：GIP - orthologs
基因位置（人类）
染色体	17號染色體
终止	48,968,596 bp
基因位置（小鼠）
染色体	小鼠11号染色体
终止	95,921,657 bp
RNA表达模式
	Top expressed in
	jejunal mucosa; ; buccal mucosa cell; ; pancreatic ductal cell; ; stromal cell of endometrium;
	Top expressed in
	crypt of lieberkuhn of small intestine; ; epithelium of small intestine; ; corneal stroma;
	查阅更多表达数据
	无数据
基因本體
分子功能	hormone activity; 血浆蛋白结合; signaling receptor binding;
細胞組分	細胞質; endoplasmic reticulum lumen; 細胞外區域; soma; secretory granule lumen; 細胞外空間;
生物學過程	response to selenium ion; response to amino acid; response to organic cyclic compound; digestive system development; regulation of insulin secretion; adult locomotory behavior; female pregnancy; response to peptide hormone; positive regulation of cAMP-mediated signaling; 記憶; response to glucose; response to lipid; response to nutrient levels; positive regulation of synaptic transmission; 探究行为; response to axon injury; 餓死; 痛覺; positive regulation of glucagon secretion; positive regulation of glucose transmembrane transport; response to carbohydrate; triglyceride homeostasis; 訊息傳遞; response to acidic pH; endocrine pancreas development; positive regulation of insulin secretion; 长时程增强作用; regulation of signaling receptor activity; G protein-coupled receptor signaling pathway; regulation of fatty acid biosynthetic process;
	来源：Amigo / QuickGO
直系同源
	2695
	14607
	ENSG00000159224
	ENSMUSG00000014351
	P09681
	P48756
	NM_004123
	NM_008119
	NP_004114
	NP_032145
	维基数据
檢視/編輯人類	檢視/編輯小鼠

葡萄糖依赖性胰岛素促分泌多肽^[5]^[6]（glucose-dependent insulinotropic polypeptide，GIP）又称抑胃肽（gastric inhibitory polypeptide），化学式为：C₂₂₆H₃₃₈O₆₆N₆₀S^[7]，是一种由十二指肠及空肠制造分泌的激素^[8]^[9]，主要功能是刺激胰岛素的分泌，对胃酸分泌则有弱抑制作用^[10]。

GIP与胰高血糖素样肽-1^[11]^[12]（GLP-1）同属于肠促胰岛素，这些分子在人們进食时能够刺激胰岛素的释放^[13]^[14]。

参考文献

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000159224 – Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000014351 – Ensembl, 2017年5月
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ 邹大进. 葡萄糖依赖性促胰岛素多肽：从基础研究到临床研究[J]. 中华糖尿病杂志,2023,15(05)：474-478.DOI:10.3760/cma.j.cn115791-20230211-00050
^ 胡质毅,龙綮新,王珣章.重组GIP蛋白的原核优化表达及其生物活性的研究[J].生物化学与生物物理进展, 2006, 033(011):1086-1093.DOI:10.3321/j.issn:1000-3282.2006.11.010.
^ 葡萄糖依赖性胰岛素促分泌多肽 | Expasy - ProtParam. web.expasy.org. [2026-03-08].
^ Meier J J, Nauck M A. Glucagon‐like peptide 1 (GLP‐1) in biology and pathology[J]. Diabetes/metabolism research and reviews, 2005, 21(2): 91-117.
^ Costanzo L. Physiology. Philadelphia, PA: Saunders/Elsevier. 2014: 337. ISBN 9781455708475.
^ Pederson R A, McIntosh C H S. Discovery of gastric inhibitory polypeptide and its subsequent fate: Personal reflections[J]. Journal of diabetes investigation, 2016, 7: 4-7.
^ 存档副本. [2024-03-10]. （原始内容存档于2024-03-10）.
^ 张勤凤, 武晓泓. 胰高血糖素样肽1受体表达及其生理功能的研究进展 [J] . 中华糖尿病杂志,2013,5 (3): 183-186. DOI: 10.3760/cma.j.issn.1674-5809.2013.03.013
^ Efendic S, Portwood N. Overview of incretin hormones[J]. Hormone and Metabolic Research, 2004, 36(11/12): 742-746.
^ Seino Y, Fukushima M, Yabe D. GIP and GLP‐1, the two incretin hormones: similarities and differences[J]. Journal of diabetes investigation, 2010, 1(1‐2): 8-23.

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000159224 – Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000014351 – Ensembl, 2017年5月

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] 邹大进. 葡萄糖依赖性促胰岛素多肽：从基础研究到临床研究[J]. 中华糖尿病杂志,2023,15(05)：474-478.DOI:10.3760/cma.j.cn115791-20230211-00050

[6] 胡质毅,龙綮新,王珣章.重组GIP蛋白的原核优化表达及其生物活性的研究[J].生物化学与生物物理进展, 2006, 033(011):1086-1093.DOI:10.3321/j.issn:1000-3282.2006.11.010.

[7] 葡萄糖依赖性胰岛素促分泌多肽 | Expasy - ProtParam. web.expasy.org. [2026-03-08].

[8] Meier J J, Nauck M A. Glucagon‐like peptide 1 (GLP‐1) in biology and pathology[J]. Diabetes/metabolism research and reviews, 2005, 21(2): 91-117.

[9] Costanzo L. Physiology. Philadelphia, PA: Saunders/Elsevier. 2014: 337. ISBN 9781455708475.

[10] Pederson R A, McIntosh C H S. Discovery of gastric inhibitory polypeptide and its subsequent fate: Personal reflections[J]. Journal of diabetes investigation, 2016, 7: 4-7.

[11] 存档副本. [2024-03-10]. （原始内容存档于2024-03-10）.

[12] 张勤凤, 武晓泓. 胰高血糖素样肽1受体表达及其生理功能的研究进展 [J] . 中华糖尿病杂志,2013,5 (3): 183-186. DOI: 10.3760/cma.j.issn.1674-5809.2013.03.013

[13] Efendic S, Portwood N. Overview of incretin hormones[J]. Hormone and Metabolic Research, 2004, 36(11/12): 742-746.

[14] Seino Y, Fukushima M, Yabe D. GIP and GLP‐1, the two incretin hormones: similarities and differences[J]. Journal of diabetes investigation, 2010, 1(1‐2): 8-23.

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