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血管紧张素转化酶2

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ACE2
Protein ACE2 PDB 1r42.png
已知的結構
PDBOrtholog search: PDBe RCSB
識別號
别名ACE2;ACEH、​angiotensin I converting enzyme 2
外部IDOMIM300335 MGI1917258 HomoloGene41448 GeneCardsACE2
RNA表达模式
PBB GE ACE2 219962 at fs.png

PBB GE ACE2 222257 s at fs.png
更多參考(基因)表达數據
直系同源
物種人類小鼠
Entrez
Ensembl
UniProt
mRNA​序列

XM_011545552、NM_021804、XM_011545549、XM_011545551、NM_001371415

NM_001130513、NM_027286

蛋白序列

NP_068576、XP_011543851、XP_011543853、XP_011543854、NP_001358344

NP_001123985、NP_081562

基因位置​(UCSC)n/an/a
PubMed​查找[1][2]
維基數據
檢視/編輯 人類檢視/編輯 小鼠

血管紧张素转化酶2(英語:Angiotensin-converting enzyme 2ACE2)是一種附著在肺,動脈,心臟,腎臟和腸道中細胞表面(細胞膜)上的酶。是一种能催化血管紧张素I转化为血管紧张素-(1-9)[3]血管紧张素II转化为血管紧张素-(1-7)[4]外肽酶。此外,ACE2还是SARS冠状病毒SARS-CoV)、嚴重急性呼吸系統綜合症冠狀病毒2型SARS-CoV-2)和人類冠狀病毒NL63受体[5]。 ACE2对ACE抑制剂药物不敏感 [6]

参考文献[编辑]

  1. ^ Human PubMed Reference:. 
  2. ^ Mouse PubMed Reference:. 
  3. ^ Donoghue M, Hsieh F, Baronas E, Godbout K, Gosselin M, Stagliano N, Donovan M, Woolf B, Robison K, Jeyaseelan R, Breitbart RE, Acton S. A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9. Circ. Res. 2000, 87 (5): E1–9. PMID 10969042. 
  4. ^ Keidar S, Kaplan M, Gamliel-Lazarovich A. ACE2 of the heart: From angiotensin I to angiotensin (1-7). Cardiovasc Res. 2007, 73 (3): 463–9. PMID 17049503. 
  5. ^ Weiss SR, Navas-Martin S. Angiotensin-converting enzyme 2--a new cardiac regulator. Microbiol Mol Biol Rev. 2005, 69 (4): 635–64. PMID 16339739. 
  6. ^ Turner AJ, Tipnis SR, Guy JL, Rice G, Hooper NM. ACEH/ACE2 is a novel mammalian metallocarboxypeptidase and a homologue of angiotensin-converting enzyme insensitive to ACE inhibitors. Canadian Journal of Physiology and Pharmacology. Apr 2002, 80 (4): 346–53. PMID 12025971. doi:10.1139/y02-021. 

延伸閲讀[编辑]

  • Turner AJ, Tipnis SR, Guy JL, Rice G, Hooper NM. ACEH/ACE2 is a novel mammalian metallocarboxypeptidase and a homologue of angiotensin-converting enzyme insensitive to ACE inhibitors. Canadian Journal of Physiology and Pharmacology. Apr 2002, 80 (4): 346–53. PMID 12025971. doi:10.1139/y02-021. 
  • Turner AJ, Hiscox JA, Hooper NM. ACE2: from vasopeptidase to SARS virus receptor. Trends in Pharmacological Sciences. Jun 2004, 25 (6): 291–4. PMID 15165741. doi:10.1016/j.tips.2004.04.001. 
  • Katovich MJ, Grobe JL, Huentelman M, Raizada MK. Angiotensin-converting enzyme 2 as a novel target for gene therapy for hypertension. Experimental Physiology. May 2005, 90 (3): 299–305. PMID 15640278. doi:10.1113/expphysiol.2004.028522. 
  • Ferrario CM, Trask AJ, Jessup JA. Advances in biochemical and functional roles of angiotensin-converting enzyme 2 and angiotensin-(1-7) in regulation of cardiovascular function. American Journal of Physiology. Heart and Circulatory Physiology. Dec 2005, 289 (6): H2281–90. PMID 16055515. doi:10.1152/ajpheart.00618.2005. 
  • Jia HP, Look DC, Hickey M, Shi L, Pewe L, Netland J, Farzan M, Wohlford-Lenane C, Perlman S, McCray PB. Infection of human airway epithelia by SARS coronavirus is associated with ACE2 expression and localization. Advances in Experimental Medicine and Biology. 2006, 581: 479–84. ISBN 978-0-387-26202-4. PMID 17037581. doi:10.1007/978-0-387-33012-9_85.  已忽略未知参数|url-access= (帮助)
  • Lazartigues E, Feng Y, Lavoie JL. The two fACEs of the tissue renin–angiotensin systems: implication in cardiovascular diseases. Current Pharmaceutical Design. 2007, 13 (12): 1231–45. PMID 17504232. doi:10.2174/138161207780618911. 
  • Raizada MK, Ferreira AJ. ACE2: a new target for cardiovascular disease therapeutics. Journal of Cardiovascular Pharmacology. Aug 2007, 50 (2): 112–9. PMID 17703127. doi:10.1097/FJC.0b013e3180986219. 
  • Dean RG, Burrell LM. ACE2 and diabetic complications. Current Pharmaceutical Design. 2007, 13 (26): 2730–5. PMID 17897017. doi:10.2174/138161207781662876. 
  • Tipnis SR, Hooper NM, Hyde R, Karran E, Christie G, Turner AJ. A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase. The Journal of Biological Chemistry. Oct 2000, 275 (43): 33238–43. PMID 10924499. doi:10.1074/jbc.M002615200. 
  • Donoghue M, Hsieh F, Baronas E, Godbout K, Gosselin M, Stagliano N, Donovan M, Woolf B, Robison K, Jeyaseelan R, Breitbart RE, Acton S. A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9. Circulation Research. Sep 2000, 87 (5): E1–9. PMID 10969042. doi:10.1161/01.res.87.5.e1. 
  • Vickers C, Hales P, Kaushik V, Dick L, Gavin J, Tang J, Godbout K, Parsons T, Baronas E, Hsieh F, Acton S, Patane M, Nichols A, Tummino P. Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase. The Journal of Biological Chemistry. Apr 2002, 277 (17): 14838–43. PMID 11815627. doi:10.1074/jbc.M200581200. 
  • Crackower MA, Sarao R, Oudit GY, Yagil C, Kozieradzki I, Scanga SE, Oliveira-dos-Santos AJ, da Costa J, Zhang L, Pei Y, Scholey J, Ferrario CM, Manoukian AS, Chappell MC, Backx PH, Yagil Y, Penninger JM. Angiotensin-converting enzyme 2 is an essential regulator of heart function. Nature. Jun 2002, 417 (6891): 822–8. PMID 12075344. doi:10.1038/nature00786. 
  • Harmer D, Gilbert M, Borman R, Clark KL. Quantitative mRNA expression profiling of ACE 2, a novel homologue of angiotensin converting enzyme. FEBS Letters. Dec 2002, 532 (1-2): 107–10. PMID 12459472. doi:10.1016/S0014-5793(02)03640-2. 
  • Donoghue M, Wakimoto H, Maguire CT, Acton S, Hales P, Stagliano N, Fairchild-Huntress V, Xu J, Lorenz JN, Kadambi V, Berul CI, Breitbart RE. Heart block, ventricular tachycardia, and sudden death in ACE2 transgenic mice with downregulated connexins. Journal of Molecular and Cellular Cardiology. Sep 2003, 35 (9): 1043–53. PMID 12967627. doi:10.1016/S0022-2828(03)00177-9. 
  • Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Genome Research. Oct 2003, 13 (10): 2265–70. PMC 403697. PMID 12975309. doi:10.1101/gr.1293003. 
  • Li W, Moore MJ, Vasilieva N, Sui J, Wong SK, Berne MA, Somasundaran M, Sullivan JL, Luzuriaga K, Greenough TC, Choe H, Farzan M. Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus. Nature. Nov 2003, 426 (6965): 450–4. PMID 14647384. doi:10.1038/nature02145. 
  • Wong SK, Li W, Moore MJ, Choe H, Farzan M. A 193-amino acid fragment of the SARS coronavirus S protein efficiently binds angiotensin-converting enzyme 2. The Journal of Biological Chemistry. Jan 2004, 279 (5): 3197–201. PMID 14670965. doi:10.1074/jbc.C300520200. 
  • Towler P, Staker B, Prasad SG, Menon S, Tang J, Parsons T, Ryan D, Fisher M, Williams D, Dales NA, Patane MA, Pantoliano MW. ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysis. The Journal of Biological Chemistry. Apr 2004, 279 (17): 17996–8007. PMID 14754895. doi:10.1074/jbc.M311191200. 

参见[编辑]

外部連結[编辑]