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Retinoblastoma 1
PDB rendering based on 1ad6.
PDB 直系同源检索:PDBe, RCSB
代号 RB1; OSRC; RB; p105-Rb; pRb; pp110
扩展标识 遗传学614041 鼠基因97874 同源基因272 ChEMBL英语ChEMBL: 5288 GeneCards英语GeneCards: RB1 Gene
PBB GE RB1 203132 at.png
PBB GE RB1 211540 s at.png
物种 人类 小鼠
Entrez英语Entrez 5925 19645
Ensembl ENSG00000139687 ENSMUSG00000022105
UniProt P06400 P13405
mRNA序列 NM_000321 NM_009029
蛋白序列 NP_000312 NP_033055
基因位置 Chr 13:
48.88 – 49.06 Mb
Chr 14:
73.18 – 73.33 Mb
PubMed查询 [1] [2]

视网膜母细胞瘤蛋白英语:retinoblastoma protein,常缩写为RbRBRB1)又译为成视网膜细胞瘤蛋白是一种抑癌蛋白,并在几种主要的癌症发生时失活[1]。Rb的功能之一是通过抑制细胞周期进程直到细胞准备妥当来防止细胞过度生长。当细胞准备好要分裂时,Rb蛋白会被磷酸化为pRb而失去抑制活性,从而使细胞周期进行下去。



Rb restricts the cell's ability to replicate DNA by preventing its progression from the G1 (first gap phase) to S (synthesis phase) phase of the cell division cycle.[4]。Rb结合并抑制E2F英语E2F家族的转录因子,which are composed of dimers of an E2F protein and a dimerization partner (DP) protein.[5] The transcription activating complexes of E2 promoter-binding–protein-dimerization partners (E2F-DP) can push a cell into S phase.[6][7][8][9][10] As long as E2F-DP is inactivated, the cell remains stalled in the G1 phase. When Rb is bound to E2F, the complex acts as a growth suppressor and prevents progression through the cell cycle.[3] The Rb-E2F/DP complex also attracts a histone deacetylase (HDAC) protein to the chromatin, reducing transcription of S phase promoting factors, further suppressing DNA synthesis.





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