辅肌动蛋白

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辅肌动蛋白英语Actinin)是一种微丝蛋白。α-辅肌动蛋白1英语ACTN1骨骼肌细胞中肌动蛋白附着于Z线所必须的[1],也是其在平滑肌中附于电子致密部分所需。起功能的辅肌动蛋白是反向平行的二聚体,which cross-links the thin filaments in adjacent sarcomeres, and therefore coordinated contractions between sarcomeres in the horizontal axis.

The non-sarcomeric α-actinins (ACTN1 and ACTN4) are widely expressed. Both ends of the rod-shaped α-actinin dimer contain actin-binding domains.

ACTN4上的突变可造成肾脏疾病局灶性节段性肾小球硬化症

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参考文献[编辑]

  1. ^ Ganong's Review of Medical Physiology, 24th Edition. Lange (Tata McGraw Hill). 2012: 100. 

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