遲發性肌肉痛（英语：delayed onset muscle soreness, DOMS）是一種運動之後24—72小時出現的肌肉痠痛或不舒適。通常會持續兩至三日。舊式理論普遍認為該痛症為乳酸積聚所引起，近期醫學研究證實真正起因為肌肉伸展時，因為不習慣運動量，肌肉纖維有微細損傷。另有一種說法是痛症並不是因為肌肉細胞受損，而是肌內強化過程之中細胞膨脹，壓住神經、血管，引致延遲性肌肉痠痛。 
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