金属蛋白

维基百科,自由的百科全书
跳转至: 导航搜索
The structure of hemoglobin. The heme cofactor, containing iron, shown in green.

金属蛋白(Metalloprotein)是一类含有配位结合的金属离子作为辅因子结合蛋白质。这是一类非常重要的蛋白质,在细胞中有多种不同的功能,包括作为运输蛋白贮存蛋白信号转导蛋白等。其中的金属离子一般是与多肽链上氨基酸残基中的氮、氧或硫原子或与蛋白质相结合的大环配体相配位。由于金属离子的特殊氧化还原性质,金属酶常用作催化生氧化还原反应的催化剂。

功能[编辑]

配位化学原理[编辑]

存储与运输相关金属蛋白[编辑]

氧载体[编辑]

细胞色素[编辑]

红氧还蛋白[编辑]

铁硫蛋白的活性位点

質體藍素[编辑]

質體藍素中铜离子的所在位置

金属离子储存与转运[编辑]

铁离子[编辑]

铜离子[编辑]

金属酶[编辑]

碳酸酐酶[编辑]

Active site of carbonic anhydrase. The three coordinating histidine residues are shown in green, hydroxide in red and white, and the zinc in gray.

维生素B12依赖酶[编辑]

固氮酶[编辑]

超氧化物歧化酶[编辑]

超氧化物歧化酶2四聚体的结构

叶绿素结合蛋白[编辑]

氢化酶[编辑]

三种氢化酶和它们的金属活性中心的结构:(A)镍铁类, (B)双铁类和(C)单铁类

核酶、脱氧核酶[编辑]

其它金属酶[编辑]

There are two types of 一氧化碳脱氢酶: one contains copper and molybdenum, the other contains nickel and iron. Parallels and differences in catalytic strategies have been reviewed.[1] Some other metalloenzymes are given in the following table, according to the metal involved.

Ion Examples of enzymes containing this ion
Magnesium[2] Glucose 6-phosphatase
Hexokinase
DNA polymerase
Vanadium vanabins
Manganese[3] Arginase
Iron[4] Catalase
Hydrogenase
IRE-BP
Aconitase
Cobalt[5] Nitrile hydratase
Methionyl aminopeptidase
Methylmalonyl-CoA mutase
Isobutyryl-CoA mutase
Nickel[6][7] Urease
Hydrogenase
Methyl-coenzyme M reductase (MCR)
Copper[8] Cytochrome oxidase
Laccase
Nitrous-oxide reductase
Nitrite reductase
Zinc[9] Alcohol dehydrogenase
Carboxypeptidase
Aminopeptidase
Beta amyloid
Cadmium[10][11] Metallothionein
thiolate proteins
Molybdenum[12] Nitrate reductase
Sulfite oxidase
Xanthine oxidase
DMSO reductase
Tungsten[13] Acetylene hydratase
various Metallothionein
Phosphatase

信号转导相关金属蛋白[编辑]

钙调素[编辑]

肌钙蛋白[编辑]

转录因子[编辑]

Zinc finger. The zinc ion (green) is coordinated by two histidine residues and two cysteine residues.

例子[编辑]

参考文献[编辑]

  1. ^ Jeoung, Jae-Hun; Fesseler, Jochen; Goetzl, Sebastian; Dobbek, Holger. Chapter 3. Carbon Monoxide. Toxic Gas and Fuel for Anaerobes and Aerobes: Carbon Monoxide Dehydrogenases. (编) Peter M.H. Kroneck and Martha E. Sosa Torres. The Metal-Driven Biogeochemistry of Gaseous Compounds in the Environment. Metal Ions in Life Sciences 14. Springer. 2014: 37–69. doi:10.1007/978-94-017-9269-1_3. 
  2. ^ Romani, Andrea M.P. Chapter 4 Magnesium Homeostasis in Mammalian Cells. (编) Banci, Lucia (Ed.). Metallomics and the Cell. Metal Ions in Life Sciences 12. Springer. 2013. doi:10.1007/978-94-007-5561-1_4. ISBN 978-94-007-5560-4.  electronic-book ISBN 978-94-007-5561-1 Template:Issn electronic-Template:Issn
  3. ^ Roth, Jerome; Ponzoni, Silvia; Aschner, Michael. Chapter 6 Manganese Homeostasis and Transport. (编) Banci, Lucia (Ed.). Metallomics and the Cell. Metal Ions in Life Sciences 12. Springer. 2013. doi:10.1007/978-94-007-5561-1_6. ISBN 978-94-007-5560-4.  electronic-book ISBN 978-94-007-5561-1 Template:Issn electronic-Template:Issn
  4. ^ Dlouhy, Adrienne C.; Outten, Caryn E. Chapter 8 The Iron Metallome in Eukaryotic Organisms. (编) Banci, Lucia (Ed.). Metallomics and the Cell. Metal Ions in Life Sciences 12. Springer. 2013. doi:10.1007/978-94-007-5561-1_8. ISBN 978-94-007-5560-4.  electronic-book ISBN 978-94-007-5561-1 Template:Issn electronic-Template:Issn
  5. ^ Cracan, Valentin; Banerjee, Ruma. Chapter 10 Cobalt and Corrinoid Transport and Biochemistry. (编) Banci, Lucia (Ed.). Metallomics and the Cell. Metal Ions in Life Sciences 12. Springer. 2013. doi:10.1007/978-94-007-5561-10_10. ISBN 978-94-007-5560-4.  electronic-book ISBN 978-94-007-5561-1 Template:Issn electronic-Template:Issn
  6. ^ Astrid Sigel, Helmut Sigel and Roland K.O. Sigel (编). Nickel and Its Surprising Impact in Nature. Metal Ions in Life Sciences 2. Wiley. 2008. ISBN 978-0-470-01671-8. 
  7. ^ Sydor, Andrew M.; Zambie, Deborah B. Chapter 11 Nickel Metallomics: General Themes Guiding Nickel Homeostasis. (编) Banci, Lucia (Ed.). Metallomics and the Cell. Metal Ions in Life Sciences 12. Springer. 2013. doi:10.1007/978-94-007-5561-10_11. ISBN 978-94-007-5560-4.  electronic-book ISBN 978-94-007-5561-1 Template:Issn electronic-Template:Issn
  8. ^ Vest, Katherine E.; Hashemi, Hayaa F.; Cobine, Paul A. Chapter 13 The Copper Metallome in Eukaryotic Cells. (编) Banci, Lucia (Ed.). Metallomics and the Cell. Metal Ions in Life Sciences 12. Springer. 2013. doi:10.1007/978-94-007-5561-10_12. ISBN 978-94-007-5560-4.  electronic-book ISBN 978-94-007-5561-1 Template:Issn electronic-Template:Issn
  9. ^ Maret, Wolfgang. Chapter 14 Zinc and the Zinc Proteome. (编) Banci, Lucia (Ed.). Metallomics and the Cell. Metal Ions in Life Sciences 12. Springer. 2013. doi:10.1007/978-94-007-5561-10_14. ISBN 978-94-007-5560-4.  electronic-book ISBN 978-94-007-5561-1 Template:Issn electronic-Template:Issn
  10. ^ Peackock, Anna F.A.; Pecoraro, Vincent. Chapter 10. Natural and artificial proteins containing cadmium. (编) Astrid Sigel, Helmut Sigel and Roland K. O. Sigel. Cadmium: From Toxicology to Essentiality. Metal Ions in Life Sciences 11. Springer. 2013: 303–337. doi:10.1007/978-94-007-5179-8_10. 
  11. ^ Freisinger, Elsa F.A.; Vasac, Milan. Chapter 11. Cadmium in Metallothioneins. (编) Astrid Sigel, Helmut Sigel and Roland K. O. Sigel. Cadmium: From Toxicology to Essentiality. Metal Ions in Life Sciences 11. Springer. 2013: 339–372. doi:10.1007/978-94-007-5179-8_11. 
  12. ^ Mendel, Ralf R. Chapter 15 Metabolism of Molybdenum. (编) Banci, Lucia (Ed.). Metallomics and the Cell. Metal Ions in Life Sciences 12. Springer. 2013. doi:10.1007/978-94-007-5561-10_15. ISBN 978-94-007-5560-4.  electronic-book ISBN 978-94-007-5561-1 Template:Issn electronic-Template:Issn
  13. ^ ten Brink, Felix. Chapter 2. Living on acetylene. A Primordial Energy Source. (编) Peter M.H. Kroneck and Martha E. Sosa Torres. The Metal-Driven Biogeochemistry of Gaseous Compounds in the Environment. Metal Ions in Life Sciences 14. Springer. 2014: 15–35. doi:10.1007/978-94-017-9269-1_2.