雙縮氨基硫脲

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雙縮氨基硫脲（Bisthiosemicarbazone）是氨基脲和二酮之間的脫去反應之產物。它的結構式為H2NHC(=S)NN=C(R1)-R2-C(R3)=NNHC(=S)NH2。雙縮氨基硫脲中有一個縮胺脲的骨架，其中酮基的氧原子由硫原子代替。本品可與細胞中的銅及鐵結合，故而有抗病毒、抗瘧疾，及抗癌的特性[1]。它也可能可以作爲遞送放射性同位素的配體，因其對於缺氧組織具有選擇性，特別是心臟及大腦[2][3][4]。雙縮氨基硫脲鋅原子螯合後，也可作爲光學顯微鏡中的熒光劑。

雙縮氨基硫脲的結構式

參見[编辑]

參考資料[编辑]

  1. ^ Palanimuthu, Duraippandi; Shinde, Sridevi Vijay; Somasundaram, Kumaravel; Samuelson, Ashoka G. In Vitro and in Vivo Anticancer Activity of Copper Bis(thiosemicarbazone) Complexes. Journal of Medicinal Chemistry. 14 February 2013, 56 (3): 722–734. PMID 23320568. doi:10.1021/jm300938r. 
  2. ^ Dearling, Jason L.; Lewis, Jason S.; Mullen, Gregory E.; Welch, Michael J.; Blower, Philip J. Copper bis(thiosemicarbazone) complexes as hypoxia imaging agents: structure-activity relationships. JBIC Journal of Biological Inorganic Chemistry. 20 April 2014, 7 (3): 249–259. doi:10.1007/s007750100291. 
  3. ^ Maurer, Richard I.; Blower, Philip J.; Dilworth, Jonathan R.; Reynolds, Christopher A.; Zheng, Yifan; Mullen, Gregory E. D. Studies on the Mechanism of Hypoxic Selectivity in Copper Bis(Thiosemicarbazone) Radiopharmaceuticals. Journal of Medicinal Chemistry. March 2002, 45 (7): 1420–1431. doi:10.1021/jm0104217. 
  4. ^ Cowley, Andrew R.; Dilworth, Jonathan R.; Donnelly, Paul S.; Labisbal, Elena; Sousa, Antonio. An Unusual Dimeric Structure of a Cu(I) Bis(thiosemicarbazone) Complex: Implications for the Mechanism of Hypoxic Selectivity of the Cu(II) Derivatives. Journal of the American Chemical Society. May 2002, 124 (19): 5270–5271. doi:10.1021/ja012668z. 


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