非特異性間質性肺炎

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非特異性間質性肺炎Non-specific interstitial pneumonia,簡稱NSIP)屬於一種特發性間質性肺炎

症狀[编辑]

症狀包含咳嗽呼吸困难,以及疲倦[1]

病因[编辑]

目前認為屬於一種自體免疫有關,可能為未分化型結締組織疾病英语undifferentiated connective tissue disease的併發症[2]

分類[编辑]

NSIP可依病理切片分為細胞性及纖維性兩種,兩種以預後不同。細胞性的鏡檢會顯示慢性發炎但纖維化較少的情形;纖維性則會顯示間質性纖維化,且發炎狀態不一。在其他種類的特發性肺炎一般有一個明顯的點狀纖維化區域,但在NSIP中沒有這種情形,一般為一整片的纖維化[3]

預後[编辑]

纖維性NSIP的五年存活率約於 86% 至 92%之間,細胞性則為 100% 。大體來說NSIP的預後較尋常性間質性肺炎英语usual interstitial pneumonia(UIP)為佳[4]

參考文獻[编辑]

  1. ^ Cottin, Vincent, et al. "Nonspecific interstitial pneumonia: individualization of a clinicopathologic entity in a series of 12 patients." American journal of respiratory and critical care medicine 158.4 (1998): 1286-1293.
  2. ^ Kinder, Brent W., et al. "Idiopathic nonspecific interstitial pneumonia: lung manifestation of undifferentiated connective tissue disease?." American journal of respiratory and critical care medicine 176.7 (2007): 691-697.
  3. ^ Travis, William D., et al. "Idiopathic nonspecific interstitial pneumonia: report of an American Thoracic Society project." American journal of respiratory and critical care medicine 177.12 (2008): 1338-1347.
  4. ^ Travis, William D., et al. "Idiopathic nonspecific interstitial pneumonia: prognostic significance of cellular and fibrosing patterns: survival comparison with usual interstitial pneumonia and desquamative interstitial pneumonia." The American journal of surgical pathology 24.1 (2000): 19-33.