2-氨基乙硫醇

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2-氨基乙硫醇
Cysteamine-2D-skeletal.png
Cysteamine 3D ball.png
Skeletal formula (top)
Ball-and-stick model of the cysteamine
系统(IUPAC)命名名称
2-Aminoethane-1-thiol
临床数据
医疗法规
识别信息
CAS注册号60-23-1  ✓
PubChem CID 6058
IUPHAR/BPS英语IUPHAR/BPS 7440
DrugBank DB00847
ChemSpider 5834
UNII 5UX2SD1KE2
KEGG D03634
ChEBI CHEBI:17141
ChEMBL英语ChEMBL CHEMBL602
其他名称 2-Aminoethanethiol
β-Mercaptoethylamine
2-Mercaptoethylamine
Decarboxycysteine
Thioethanolamine
Mercaptamine
化学信息
化学式 C2H7NS
摩尔质量 77.15 g·mol−1
物理性质
熔点 99.5 °C(211.1 °F)
沸点 130[1] °C(266 °F)

2-氨基乙硫醇是一种用于治疗多种疾病的药物,经FDA批准用于治疗胱氨酸症,可口服或作为滴眼液成分。[2][3][4][5]

制备[编辑]

硫化氢氢氧化钠甲醇溶液反应,得到的新溶液和2-氯乙胺盐酸盐反应,可以得到2-氨基乙硫醇。[6]氮丙环硫化氢反应,也能制得产物。[7]

参考文献[编辑]

  1. ^ Bestian, Herbert; Heyna, J.; Bauer, A.; Ehlers, G.; Hirsekorn, B.; Jacobs, T.; Noll, W.; Weibezahn, W.; Romer, F. Reactions of ethylenimine. Justus Liebigs Annalen der Chemie, 1950. 566: 210-244. ISSN: 0075-4617
  2. ^ US Label: Cysteamine bitartrate delayed-release capsules (PDF). FDA. August 2015. 
  3. ^ US Label: Cysteamine bitartrate capsules (PDF). FDA. June 2007. 
  4. ^ US Label: Cysteamine ophthalmic solution (PDF). FDA. October 2012. 
  5. ^ Shams, F; Livingstone, I; Oladiwura, D; Ramaesh, K. Treatment of corneal cystine crystal accumulation in patients with cystinosis.. Clinical Ophthalmology (Auckland, N.Z.). 10 October 2014, 8: 2077–84. PMC 4199850. PMID 25336909. doi:10.2147/OPTH.S36626. 
  6. ^ Narita, Naoki; Tanaka, Yoshinori; Kuwazuka, Toshiaki; Suzuki, Masayoshi; Watanabe, Seiichi. Preparation of mercaptoamines from halogenoalkylamines and hydrogen sulfides. Jpn. Kokai Tokkyo Koho, 1992. JP 04120052 A.
  7. ^ Edward James Mills, Marston Taylor Bogert. The Synthesis of Some New Pyrimidines and Uric Acids fom Cystamine 1. Journal of the American Chemical Society. 1940-05, 62 (5): 1173–1180 [2019-06-26]. ISSN 0002-7863. doi:10.1021/ja01862a053 (英语).