5-羟色胺、去甲肾上腺素和多巴胺再摄取抑制剂
（重定向自5-羥色胺、去甲腎上腺素和多巴胺再攝取抑制劑）
 | 此條目需要擴充。 (2015年9月29日) |
5-羟色胺、去甲肾上腺素和多巴胺再摄取抑制剂（英語：serotonin–norepinephrine–dopamine reuptake inhibitor，SNDRI），也称作三重再摄取抑制剂（TRI），是多种单胺类神经递质的再摄取抑制剂，原理为通过抑制5-羟色胺转运体、去甲肾上腺素转运体和多巴胺转运体体来分别抑制5-羟色胺、 去甲肾上腺素和多巴胺的再摄取。这个作用会增加这些神经递质在突触间隙的浓度。
SNDRI作為一系列疾病的藥物候選而被開發，如抗憂鬱劑[1][2][3][4][5] 和治療肥胖、古柯鹼成癮、注意力缺陷/過動症(ADHD)及慢性疼痛的藥物。SNDRI作為選擇性血清素再吸收抑制劑(SSRIs)及血清素-去甲腎上腺素再吸收抑制劑(SNRIs)的延伸，增加了多巴胺的再吸收抑制作用，這被認為具有增加療效的可能，但副作用及藥物濫用的可能也隨之增加。
引用[编辑]
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