周期蛋白D1

周期蛋白D1
周期蛋白D1
	Rendering based on PDB 2W96.
有效结构
PDB	直系同源检索：PDBe, RCSB
PDB查询代码列表
	2W96, 2W99, 2W9F, 2W9Z
标识
代号	CCND1; BCL1; D11S287E; PRAD1; U21B31
扩展标识	遗传学：168461 鼠基因：88313 同源基因：1334 ChEMBL: 3610 GeneCards: CCND1 Gene
基因本体论描述
分子功能	· protein kinase activity; · protein binding; · cyclin-dependent protein serine/threonine kinase regulator activity; · enzyme binding; · protein kinase binding; · protein complex binding;
细胞成分	· cyclin-dependent protein kinase holoenzyme complex; · intracellular; · nucleus; · nucleoplasm; · cytosol; · tight junction; · membrane;
生物过程	· G1 phase of mitotic cell cycle; · G1/S transition of mitotic cell cycle; · S phase of mitotic cell cycle; · mitotic cell cycle; · re-entry into mitotic cell cycle; · liver development; · positive regulation of protein phosphorylation; · response to DNA damage stimulus; · lactation; · response to iron ion; · response to X-ray; · response to organic nitrogen; · negative regulation of Wnt receptor signaling pathway; · negative regulation of epithelial cell differentiation; · endoplasmic reticulum unfolded protein response; · organ regeneration; · mitotic G1 DNA damage checkpoint; · response to magnesium ion; · response to vitamin E; · Leydig cell differentiation; · mammary gland epithelial cell proliferation; · positive regulation of mammary gland epithelial cell proliferation; · response to drug; · response to estrogen stimulus; · fat cell differentiation; · response to ethanol; · positive regulation of cyclin-dependent protein kinase activity; · cell division; · response to corticosterone stimulus; · response to calcium ion; · canonical Wnt receptor signaling pathway; · mammary gland alveolus development; · response to UV-A; · regulation of G1/S transition of mitotic cell cycle;
	Sources: Amigo / QuickGO
RNA表达模式
	更多表达数据
直系同源体
物种	人类
Entrez	595
Ensembl	ENSG00000110092
UniProt	P24385
mRNA序列	NM_053056
蛋白序列	NP_444284
基因位置	Chr 11:; 69.46 – 69.47 Mb
PubMed查询	[1]
	查; 论; 编;

G1/S-特异性周期蛋白-D1是一个由人类CCND1基因所编码的蛋白质^[1]^[2]。

该基因编码的蛋白质属于高度保守的周期蛋白家族，该家族成员的显著特征是贯穿细胞周期，其蛋白质丰度周期性地急剧改变。周期蛋白作为CDK（周期蛋白依赖性激酶）的调节因子。不同的周期蛋白表现出各自独特的表达及降解特性，这有助于每个有丝分裂事件在时间上的协调性。周期蛋白D1这种亚型的周期蛋白与CDK4或CDK6形成复合物并作为它们的调节亚基，这两种周期蛋白依赖性激酶对于G₁到S期的转变来说是不可或缺的。该蛋白表现出与抑癌基因Rb有着相互作用，且此基因的表达受Rb的正向调控。周期蛋白D1发生突变、扩增及过表达将会改变细胞周期进程，这些现象常发生在多种肿瘤中并可能导致肿瘤发生^[3]。

使用周期蛋白D1进行免疫组化染色可用于诊断套细胞淋巴瘤。

另见

参考文献

^ Motokura T, Bloom T, Kim HG, Juppner H, Ruderman JV, Kronenberg HM, Arnold A. A novel cyclin encoded by a bcl1-linked candidate oncogene. Nature. May 1991, 350 (6318): 512–5. PMID 1826542. doi:10.1038/350512a0.
^ Lew DJ, Dulic V, Reed SI. Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast. Cell. October 1991, 66 (6): 1197–206. PMID 1833066. doi:10.1016/0092-8674(91)90042-W.
^ Entrez Gene: CCND1 cyclin D1.

深入阅读

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Hall M, Bates S, Peters G. Evidence for different modes of action of cyclin-dependent kinase inhibitors: p15 and p16 bind to kinases, p21 and p27 bind to cyclins. Oncogene. 1995, 11 (8): 1581–8. PMID 7478582.
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[pmid1826542-1] Motokura T, Bloom T, Kim HG, Juppner H, Ruderman JV, Kronenberg HM, Arnold A. A novel cyclin encoded by a bcl1-linked candidate oncogene. Nature. May 1991, 350 (6318): 512–5. PMID 1826542. doi:10.1038/350512a0.

[pmid1833066-2] Lew DJ, Dulic V, Reed SI. Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast. Cell. October 1991, 66 (6): 1197–206. PMID 1833066. doi:10.1016/0092-8674(91)90042-W.

[entrez-3] Entrez Gene: CCND1 cyclin D1.

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[2]

[3]