CXCL1

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Chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
PDB rendering based on 1mgs.
有效结构
PDB 直系同源检索:PDBe, RCSB
标识
代号 CXCL1; FSP; GRO1; GROa; MGSA; MGSA-a; NAP-3; SCYB1
扩展标识 遗传学155730 鼠基因3037818 同源基因117693 GeneCards: CXCL1 Gene
直系同源体
物种 人类 小鼠
Entrez 2919 330122
Ensembl ENSG00000163739 ENSMUSG00000029379
UniProt P09341 Q6W5C0
mRNA序列 NM_001511 NM_203320
蛋白序列 NP_001502 NP_976065
基因位置 Chr 4:
74.74 – 74.74 Mb
Chr 5:
90.79 – 90.79 Mb
PubMed查询 [1] [2]

CXCL1英语:Chemokine (C-X-C motif) ligand 1)是一小分子的细胞因子属于CXC趋化因子家族[1]。又被称作生长调节致癌基因α (Growth-regulated oncogene alpha, GROα)[1][2][3]。 趋化因子CXCL1是由巨噬细胞中性粒细胞上皮细胞表达的[4][5]。趋化因子CXCL1对中性粒细胞有细胞趋化作用[1]。CXCL1结合到趋化因子受体CXCR2上而起细胞趋化作用[6]。人类的CXCL1与许多CXC类的趋化因子基因相邻聚集在第四染色体上[7] 。CXCL1的主要作用包括新血管形成、炎症反应、伤口愈合[8]和肿瘤形成[9][10]

参见[编辑]

参考文献[编辑]

  1. ^ 1.0 1.1 1.2 Moser B, Clark-Lewis I, Zwahlen R, Baggiolini M. Neutrophil-activating properties of the melanoma growth-stimulatory activity. J Exp Med. 1990 May 1;171(5):1797-802.
  2. ^ Anisowicz, A., Bardwell, L., Sager, R. Constitutive overexpression of a growth-regulated gene in transformed Chinese hamster and human cells. Proc. Nat. Acad. Sci. 84: 7188-7192, 1987.
  3. ^ Richmond, A., Thomas, H. G. (1988) Melanoma growth stimulatory activity: isolation from human melanoma tumors and characterization of tissue distribution J. Cell. Biochem. 36,185-198
  4. ^ Iida N, Grotendorst GR. Cloning and sequencing of a new gro transcript from activated human monocytes: expression in leukocytes and wound tissue. Mol Cell Biol. 1990 Oct;10(10):5596-9.
  5. ^ Becker S, Quay J, Koren HS, Haskill JS. Constitutive and stimulated MCP-1, GRO alpha, beta, and gamma expression in human airway epithelium and bronchoalveolar macrophages. Am J Physiol. 1994 Mar;266(3 Pt 1):L278-86.
  6. ^ Devalaraja, R. M., Nanney, L. B., Du, J., Qian, Q., Yu, Y., Devalaraja, M. N., Richmond, A. (2000) Delayed wound healing in CXCR2 knockout mice J. Investig. Dermatol. 115,234-244
  7. ^ Richmond A, Balentien E, Thomas HG, Flaggs G, Barton DE, Spiess J, Bordoni R, Francke U, Derynck R. Molecular characterization and chromosomal mapping of melanoma growth stimulatory activity, a growth factor structurally related to beta-thromboglobulin. EMBO J. 1988 Jul;7(7):2025-33.
  8. ^ Devalaraja, R. M., Nanney, L. B., Du, J., Qian, Q., Yu, Y., Devalaraja, M. N., Richmond, A. (2000) Delayed wound healing in CXCR2 knockout mice J. Investig. Dermatol. 115,234-244
  9. ^ Anisowicz, A., Bardwell, L., Sager, R. Constitutive overexpression of a growth-regulated gene in transformed Chinese hamster and human cells. Proc. Nat. Acad. Sci. 84: 7188-7192, 1987.
  10. ^ Richmond, A., Thomas, H. G. (1988) Melanoma growth stimulatory activity: isolation from human melanoma tumors and characterization of tissue distribution J. Cell. Biochem. 36,185-198