双氯芬酸钠

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双氯芬酸钠
Diclofenac.svg
系统(IUPAC)命名名称
2-(2-(2,6-dichlorophenylamino)phenyl)acetic acid
临床数据
妊娠分级
  • AU: A
  • B (1st. and 2nd. trimenon), X (third trimenon)
合法状态
  • UK: 处方药(-only) (POM)
  • Rx-only most preparations/countries. Limited OTC some countries. Manufacture and veterinary use is banned in India, Nepal and Pakistan due to imminent extinction of local vultures.
给药途径 oral, rectal, im, iv (renal- and gallstones), topical
药代动力学数据
生物利用度 100%
蛋白结合度 >99%
代谢 hepatic, no active metabolites exist
生物半衰期 1.2-2 hr (35% of the drug enters enterohepatic recirculation)
排泄 biliary, only 1% in urine
识别信息
CAS注册号 15307-86-5
ATC代码 M01AB05 M02AA15, S01BC03
PubChem CID: 3033
DrugBank APRD00527
ChemSpider 2925
化学数据
化学式 C14H11Cl2NO2
摩尔质量 296.148 g/mol

双氯芬酸钠DiclofenacDiclofenac potassium)是一种衍生于苯乙酸类非类固醇消炎止痛药。本药用于骨节炎骨膜炎骨骼肌炎关节炎痛风风湿

一般建议用美洛昔康(Meloxicam)来代替双氯芬酸钠。因Diclofenac除了在人体使用会产生副作用外、也来自于秃鹰吃了食用Diclofenac的家畜后所造成秃鹰死亡等案例之影响。[1]

作用机制[编辑]

其作用机理为抑制环氧化酶活性从而阻断花生四烯酸前列腺素的转化生成,因前列腺素为引起疼痛、发烧及发炎等之现象的主要因子。

成药[编辑]

食用[编辑]

成年人每日推荐剂量为每次两十五到五十毫克每日三次,每日最大用量一百五十毫克。小儿本药只能在医生指导下服用。小儿只能注射服用。

外用凝胶剂[编辑]

仅为外用作为一般酸痛凝胶剂,每公克约含Diclofenac Sodium 10mg。具有消炎、抗风湿、止痛,及解热等作用。每日3~4次;每次2~4公克。小儿、孕妇、授乳妇等使用本药建议在医生或药师、药剂生指导下使用,不建议自行使用。

肛门塞剂[编辑]

肛门塞剂,肠溶锭剂型,其主要有消炎、镇痛及解热作用。Voren (台湾 永信药品)。

成药商标[编辑]

  • Arthrotec:加入Misoprostol合用。
  • Voren (台湾)
  • 诺华:Voltaren扶他林(加拿大、中国大陆)、服他灵(香港,需要医生处方,亦有用于处方一般关节痛以外的骨痛或肌肉痛)

禁忌[编辑]

患有胃溃疡、十二指肠溃疡、血友病、肝病、心病、肾病者禁用。本药孕妇禁用。服药期间出现过敏、恶心、泻肚困难时应立即就医。

商标名称[编辑]

药品的商业名称包括:

  • Aclonac Emulsi Gel
  • A-fenac (Bangladesh)
  • Abitren
  • Acteric (Costa Rica)
  • Almiral
  • Anaflex (Argentina)
  • Anuva
  • Arthrotec (combination with misoprostol)
  • Artifen (Pakistan Abbott Laboratories LTD)
  • Befol
  • Berifen
  • Betaren
  • Bufenac Forte
  • Cambia
  • Cataflam
  • Catafast
  • Caflam (Pakistan)
  • Clafen
  • Clofast
  • Clonac
  • Dedolor
  • Deflamat
  • Deflox
  • Dici K (diclofenac potassium, India)
  • Diclac
  • Diclo M (India & Myanmar) V.I.P Pharma
  • Dicloberl
  • Diclobene
  • Diclo-Denk (Germany)
  • Diclofenac
  • Diclofenac-Asteria (USA and Korea)
  • Diclofenaco Normon (Spain)
  • Diclofenacum
  • Dicloflam (South Africa)
  • Dicloflex
  • Diclogem
  • Diclogesic (Jordan and Romania)
  • Diclohexal
  • Diclon
  • Diclomar (Argentina)
  • Diclomex (Finland)
  • Dicloran (Malaysia)
  • Diclowin Plus (India)
  • Diclon
  • Diclopar (Tanzania)
  • Diclotab (Laos)
  • Diklofenak T Actavis (Sweden)
  • Difen
  • Difenac (Venezuela)
  • Difene
  • Difnal (Malaysia)
  • Dinac (Nepal)
  • Dioxaflex (Latin America, Central America)
  • Disflam K (diclofenac potassium, Central America)
  • Dolex
  • Dolphin (Egypt)
  • Dolmina (Czech Republic)
  • Dyloject
  • Feloran
  • Fenac (diclofenac potassium, Australia)
  • Flamrase
  • Flector Patch
  • Flogozan (Mexico)
  • Idinac (India)
  • Immunagel (India)
  • Iodex UltraGel (India)
  • Kemoren (Indonesia)
  • Klodifen
  • Modifenac
  • Morbidic (India)
  • Motifene
  • Naklofen
  • Neofenac (Bangladesh)
  • Neopyrazon (United Laboratories, ASIA)
  • Oflam
  • Olfen
  • Ortofen
  • Phlogin - Diclofenac Sodium (Pakistan)
  • Panamor
  • Parazone-DP (combination of Paracetamol & Diclofenac potassium)
  • Pennsaid
  • Pritaren
  • Rapidus
  • Rapten-K
  • Reactin (India)
  • Rhumalgan
  • Rofenac (Middle East)
  • Rufenal
  • Safeguard (combination with misoprostol)
  • Sandoz (diclofenac sodium, Australia)
  • Solaraze
  • Seradic (India)
  • Topac
  • Trabona
  • Tratul (Austria, Romania, Moldova)
  • Uno
  • Veltex CR (South Africa)
  • Vetagesic
  • Viclofen (Australia)
  • Vinil (Paraguay)
  • Voldic
  • Volini (India)
  • Volfenac (Thailand)
  • Volna-k (Taiwan)
  • Voltaflam (India)
  • Voltaren (Argentina, Australia, Belgium, Egypt, France, Germany, Israel, New Zealand, Norway, Portugal, Russia, South Africa, Sweden, Turkey)
  • Voltaren Emulgel (Australia, Canada, New Zealand, UK)
  • Voltaren Gel (US)
  • Voltarol
  • Voltarol Emulgel
  • Voltarol Pain-eze
  • Voltfast
  • Voren (Taiwan)
  • Voltral (UK, Pakistan)
  • Votrex
  • Vostar
  • Votalin (China)
  • Voveran
  • Vurdon
  • Zipsor
  • Zolterol
  • Zorvolex-free acid diclofenac
  • Zengesic (combination of Paracetamol & Diclofenac sodium)
  • Hitflam (Ambee Pharmaceuticals Ltd. Bangladesh)

注释[编辑]

  1. ^ "Vet drug 'killing Asian vultures'", BBC News,28 January 2004, webpage:BBC583. (英文)

外部链接[编辑]